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Akademický článek

Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux

Autor: Yuxuan Chen, Junyu Shen, Mengyun Yuan, Huaizhi Li, Yaqi Li, Shanshan Zheng, Bo Han, Cancan Zhang, Shenlin Liu, Qingmin Sun, Jian Wu

Publikováno v: Journal of Advanced Research, Vol 67, Iss , Pp 331-348 (2025)

Introduction: Dehydrocostus lactone (Dehy), a natural sesquiterpene lactone from Saussurea lappa Clarke, displays remarkable efficacy in treating cancer and gastrointestinal disorders. However, its anti-gastric cancer (GC) effect remains poorly under

Externí odkaz: https://doaj.org/article/6c737dbfbffb4589823b501a3a15c34b

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Akademický článek

Aclysiran, an RNAi therapeutic agent targeting ACLY, treats hypercholesterolemia and atherosclerosis in ApoE–/– mice

Autor: Meijie Chen, Peter J. Little, Sudong Kong, Maciej Banach, Jianping Weng, Suowen Xu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 14, Iss 12, Pp 5505-5508 (2024)

Externí odkaz: https://doaj.org/article/06de8c1c6b60458b85e2a043b4eb1ba4

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Akademický článek

Role of ATP citrate lyase and its complementary partner on fatty acid synthesis in gastric cancer

Autor: Chunlei Li, Wenxuan Liu, Youzhao Liu, Weixing Wang, Wenhong Deng

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract ATP citrate lyase (ACLY) and acyl-CoA short-chain synthetases 2 (ACSS2) are key enzymes in lipid metabolism. We explored the role of ACLY in gastric cancer (GC) and the effect of ACLY and ACSS2 compensation on GC growth. We used immunohistoc

Externí odkaz: https://doaj.org/article/b61cdac29ba14f8590fc71b2c28af53a

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Akademický článek

A Graphene-Based Lipid Modulation Nanoplatform for Synergetic Lipid Starvation/Chemo/Photothermal Therapy of Oral Squamous Cell Carcinoma

Autor: Li R, Li Y, Song Z, Gu Y, Jiao X, Wan C, Liu T, Zhang R, Gao R, Wang X

Publikováno v: International Journal of Nanomedicine, Vol Volume 19, Pp 11235-11255 (2024)

Ran Li,1,2,* Yanwei Li,1,2,* Zijian Song,1,2 Yixuan Gu,1,2 Xiaofeng Jiao,1,2 Chaoqiong Wan,1,2 Tiantian Liu,1,2 Rongrong Zhang,1,2 Ruifang Gao,1,2 Xiangyu Wang1,2 1Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials,

Externí odkaz: https://doaj.org/article/e472cec31970495897c56a6a750d37ea

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Akademický článek

Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis

Autor: Jun-Su Zhou, Long Cheng, Yuan Gao, Zhan-Peng Ge, Bin Zhou, Jing-Ya Li, Jin-Xin Zhao, Jian-Min Yue

Publikováno v: Engineering, Vol 38, Iss , Pp 144-154 (2024)

Four new norditerpenoid heterodimers with different dimerization patterns—namely, trigofragiloids A–C (denoted as compounds 1–3) and (+)- and (−)-trigofragiloid D (compound 4)—and three new phenanthrenone norditerpenoids—namely, trigofrag

Externí odkaz: https://doaj.org/article/84df797e52eb4b288900c5a9fe35258e

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Akademický článek

Clinical Application of PINK1 and ACSL4 Protein Levels in the Acute Myocardial Infarction Patients and Prognosis Evaluation After PCI

Autor: Ao W, Duan P, Luo P, Xiang D, Wang Q, Ren Y, He Q

Publikováno v: Research Reports in Clinical Cardiology, Vol Volume 15, Pp 45-53 (2024)

Wei Ao,1 Ping Duan,2 Ping Luo,1 Dikai Xiang,1 Qin Wang,1 Yanjiao Ren,1 Qiwei He1 1Department of Cardiology, Yueyang People’s Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People’s Republic of China; 2Department of Cardi

Externí odkaz: https://doaj.org/article/7880fdb84c644153916ced992dbe8761

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Akademický článek

A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones

Autor: Rauckhorst, Adam J. ^{1, 2, 3}, Sheldon, Ryan D. ^{1, 9}, Pape, Daniel J. ¹, Ahmed, Adnan ¹, Falls-Hubert, Kelly C. ¹, Merrill, Ronald A. ¹, Brown, Reid F. ^{1, 3}, Deshmukh, Kshitij ¹, Vallim, Thomas A. ⁷, Deja, Stanislaw ⁸, Burgess, Shawn C. ⁸, Taylor, Eric B. ^{1, 2, 3, 4, 5, 6, 10, ∗}

Publikováno v: In Cell Metabolism 7 January 2025 37(1):255-273

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Akademický článek

Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase

Autor: Liu, Joyce Y. ^{1, 2, 3, 11}, Kuna, Ramya S. ^{7, 8, 11}, Pinheiro, Laura V. ^{1, 2, 3, 11}, Nguyen, Phuong T.T. ^{1, 2, 5}, Welles, Jaclyn E. ^{9, 10}, Drummond, Jack M. ^{1, 2}, Murali, Nivitha ^{1, 2}, Sharma, Prateek V. ^{1, 2, 4}, Supplee, Julianna G. ^{1, 2, 3}, Shiue, Mia ^{1, 2}, Zhao, Steven ^{1, 2, 4}, Farria, Aimee T. ^{1, 2}, Kumar, Avi ^{7, 8}, Ruchhoeft, Mauren L. ^{7, 8}, Demetriadou, Christina ^{1, 6}, Kantner, Daniel S. ⁶, Chatoff, Adam ⁶, Megill, Emily ⁶, Titchenell, Paul M. ^{9, 10}, Snyder, Nathaniel W. ⁶, Metallo, Christian M. ^{7, 8, ∗}, Wellen, Kathryn E. ^{1, 2, 12, ∗∗}

Publikováno v: In Cell Metabolism 7 January 2025 37(1):239-254

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Akademický článek

The pathological significance and potential mechanism of ACLY in cholangiocarcinoma

Autor: Xiaoyan Sun, Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Jing Xu, Hongyang Wang, Wen Yang

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Background and aimCholangiocarcinoma (CCA) is a rare cancer, yet its incidence and mortality rates have been steadily increasing globally over the past few decades. Currently, there are no effective targeted treatment strategies available for patient

Externí odkaz: https://doaj.org/article/a2528e3e1f6e48f3806a4da11287a408

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