MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity

Autor: BENASCIUTTI E, MARIANI E, OLIVA L, SCOLARI M, PERILLI E, BARRAS E, MILAN E, ORFANELLI U, FAZZALARI NL, CAMPANA L, CAPOBIANCO A, OTTEN L, PARTICELLI F, ACHA ORBEA H, BARUFFALDI F, FACCIO R, REITH W, CENCI S., SITIA , ROBERTO

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Min
Journal of Bone and Mineral Research, Vol. 29, No 2 (2014) pp. 290-303

The molecular networks controlling bone homeostasis are not fully understood. The common evolution of bone and adaptive immunity encourages the investigation of shared regulatory circuits. MHC Class II Transactivator (CIITA) is a master transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9301c9989c5f22e3848f72eebd0ff7c3

The primary in vivo immune response to Mls-1 (Mtv-7 sag). Route of injection determines the immune response pattern.

Autor: Andersson, M.¹, Acha-Orbea, H.¹

Publikováno v: Immunology. Nov94, Vol. 83 Issue 3, p438-443. 6p.

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Role of major histocompatibility complex class II expression by non-hematopoietic cells in autoimmune and inflammatory disorders: facts and fiction

Autor: Duraes F V, Thelemann C, Sarter K, Acha-Orbea H, Hugues S, Reith W

Publikováno v: Tissue Antigens
Tissue Antigens, Vol. 82, No 1 (2013) pp. 1-15
Tissue antigens

It is well established that interactions between CD4(+) T cells and major histocompatibility complex class II (MHCII) positive antigen-presenting cells (APCs) of hematopoietic origin play key roles in both the maintenance of tolerance and the initiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2b1e58b22853d942afb23bc4180c6f56

Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells

Autor: Wang, Y., Kissenpfennig, Adrien, Mingueneau, M., Richelme, S., Perrin, P., Chevrier, S., Genton, C., Lucas, B., DiSanto, J.P., Acha-Orbea, H., Malisse, [No Value]

Publikováno v: Wang, Y, Kissenpfennig, A, Mingueneau, M, Richelme, S, Perrin, P, Chevrier, S, Genton, C, Lucas, B, DiSanto, J P, Acha-Orbea, H & Malisse, N V 2008, ' Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. ' Journal of Immunology, vol. 180(3), pp. 1565-1575 .

Mutant mice where tyrosine 136 of linker for activation of T cells (LAT) was replaced with a phenylalanine (Lat(Y136F) mice) develop a fast-onset lymphoproliferative disorder involving polyclonal CD4 T cells that produce massive amounts of Th2 cytoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2607::58491e987ab7a1228f17377b9a468bf6
https://pure.qub.ac.uk/portal/en/publications/th2-lymphoproliferative-disorder-of-laty136f-mutant-mice-unfolds-independently-of-tcrmhc-engagement-and-is-insensitive-to-the-action-of-foxp3-regulatory-t-cells(a185c6bd-1c0c-4de8-b79b-b5e4662f1d35).html