Zobrazeno 1 - 10
of 112
pro vyhledávání: '"ACETAMINOPHEN METABOLISM"'
Autor:
Gaurav Thareja, Anne M. Evans, Spencer D. Wood, Nisha Stephan, Shaza Zaghlool, Anna Halama, Gabi Kastenmüller, Aziz Belkadi, Omar M. E. Albagha, The Qatar Genome Program Research Consortium, Karsten Suhre
Publikováno v:
Metabolites, Vol 12, Iss 6, p 496 (2022)
Genome-wide association studies (GWAS) with non-targeted metabolomics have identified many genetic loci of biomedical interest. However, metabolites with a high degree of missingness, such as drug metabolites and xenobiotics, are often excluded from
Externí odkaz:
https://doaj.org/article/8ae1076577854fff893f9f63a2fbdfe7
Autor:
Gaurav, Thareja, Anne M, Evans, Spencer D, Wood, Nisha, Stephan, Shaza, Zaghlool, Anna, Halama, Gabi, Kastenmüller, Aziz, Belkadi, Omar M E, Albagha, The Qatar Genome Program Research Consortium, Karsten, Suhre
Publikováno v:
Metabolites 12:496 (2022)
Metabolites; Volume 12; Issue 6; Pages: 496
Metabolites; Volume 12; Issue 6; Pages: 496
Genome-wide association studies (GWAS) with non-targeted metabolomics have identified many genetic loci of biomedical interest. However, metabolites with a high degree of missingness, such as drug metabolites and xenobiotics, are often excluded from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37843c77ffe094b727b42ff8b8fcfad
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=65539
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=65539
Akademický článek
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Akademický článek
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Publikováno v:
Digestive and Liver Disease. 47:1039-1046
Background The effect of liver resection on acetaminophen metabolism and whether it is affected by residual liver volume is poorly understood. Methods We investigated the effects of liver resection on acetaminophen metabolism in a single centre, pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c40c83941870bf943088c3a75345d3
https://doi.org/10.1016/j.dld.2015.08.005
https://doi.org/10.1016/j.dld.2015.08.005
An improved understanding of in vivo-to-in vitro hepatocyte changes is crucial to interpreting in vitro data correctly and further improving hepatocyte-based in vitro-to-in vivo extrapolations to human targets. We demonstrate using virtual experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf45b914f310361d8dd7e6f44bc2963
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 365(1)
An improved understanding of in vivo-to-in vitro hepatocyte changes is crucial to interpreting in vitro data correctly and further improving hepatocyte-based in vitro-to-in vivo extrapolations to human targets. We demonstrate using virtual experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee78dac4488f400f03d14a34e49c75b8
https://pubmed.ncbi.nlm.nih.gov/29434053
https://pubmed.ncbi.nlm.nih.gov/29434053
Publikováno v:
Pharmaceutical Research
Purpose To investigate the hypothesis that paracetamol is absorbed faster from a hot drink than from a standard tablet using simultaneous scintigraphic imaging and pharmacokinetic sampling. Methods Twenty-five healthy male volunteers received both pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6b870c5267147b78da18942a3363ae
https://doi.org/10.1007/s11095-014-1309-3
https://doi.org/10.1007/s11095-014-1309-3
Akademický článek
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Autor:
Timothy Davern
Publikováno v:
Clinics in Liver Disease. 16:231-245
Drug-induced liver injury (DILI), also known as hepatotoxicity, refers to liver injury caused by drugs or other chemical agents, and represents a special type of adverse drug reaction. It has been estimated that more than 600 drugs and chemicals have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90da40ebfc3eef2b656edae5fe1c491e
https://doi.org/10.1016/j.cld.2012.03.002
https://doi.org/10.1016/j.cld.2012.03.002