Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Autor: Nicholas C. Wu, Xueyong Zhu, Marit J. van Gils, Jakob Kreye, Chang-Chun D Lee, Linghang Peng, Hejun Liu, Meng Yuan, Abigail M. Jackson, Dennis R. Burton, Andrew B. Ward, Rogier W. Sanders, David Nemazee, S. Momsen Reincke, Harald Prüss, Ian A. Wilson, Deli Huang

Publikováno v: Science 373(6556), 818-823 (2021). doi:10.1126/science.abh1139
bioRxiv
article-version (status) pre
article-version (number) 1
Science, 373(6556), 818-823. American Association for the Advancement of Science
Science (New York, N.y.)

The protective efficacy of neutralizing antibodies (nAbs) elicited during natural infection with SARS-CoV-2 and by vaccination based on its spike protein has been compromised with emergence of the recent SARS-CoV-2 variants. Residues E484 and K417 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a44f112f84d84b18800a45c2c75d8b9
http://www.scopus.com/inward/record.url?scp=85112522453&partnerID=8YFLogxK

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Autor: Prelli Bozzo, Caterina, Nchioua, Rayhane, Volcic, Meta, Koepke, Lennart, Krüger, Jana, Schütz, Desiree, Heller, Sandra, Stürzel, Christina M., Kmiec, Dorota, Conzelmann, Carina, Müller, Janis, Zech, Fabian, Braun, Elisabeth, Groß, Rüdiger, Wettstein, Lukas, Weil, Tatjana, Weiß, Johanna, Diofano, Federica, Rodríguez Alfonso, Armando A., Wiese, Sebastian, Sauter, Daniel, Münch, Jan, Goffinet, Christine, Catanese, Alberto, Schön, Michael, Boeckers, Tobias M., Stenger, Steffen, Sato, Kei, Just, Steffen, Kleger, Alexander, Sparrer, Konstantin M. J., Kirchhoff, Frank

Publikováno v: Nature Communications 12(1), 4584 (2021). doi:10.1038/s41467-021-24817-y
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications

Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc49410437957521bf8a06e7e4be82f2
https://pub.dzne.de/record/162717

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Autor: Shu Liu, Annika Hornberger, Katerina Konstantoulea, Philip Denner, Stefan F. Lichtenthaler, Stefanie-Elisabeth Heumüller, Lydia Paulsen, André Hossinger, Joost Schymkowitz, Frederic Rousseau, Ina Vorberg, Manuela Neumann, Oleksandra Buravlova, Stephan A. Müller

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications 12(1), 5739 (2021). doi:10.1038/s41467-021-25855-2

Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble homotypic proteins. Proteopathic seeds can be released into the extracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c267871c21edbc58285a17a04aad283d
https://pubmed.ncbi.nlm.nih.gov/34667166

A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

Autor: Linghang Peng, Fangzhu Zhao, Meng Yuan, Xueyong Zhu, Dennis R. Burton, Hejun Liu, Nicholas C. Wu, Chang-Chun D Lee, Marit J. van Gils, David Nemazee, Deli Huang, Sandhya Bangaru, Ian A. Wilson, Hans Christian Kornau, Shawn Barman, Harald Prüss, Rogier W. Sanders, Jakob Kreye, S. Momsen Reincke, Andrew B. Ward

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1
Cell host & microbe, 29(5), 806-818.e6. Cell Press
Cell host and microbe 29(5), 806-818.e6 (2021). doi:10.1016/j.chom.2021.04.005
Cell Host & Microbe

Coronaviruses have caused several human epidemics and pandemics including the ongoing coronavirus disease 2019 (COVID-19). Prophylactic vaccines and therapeutic antibodies have already shown striking effectiveness against COVID-19. Nevertheless, conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf08c7509dedd958cc92d18c46463d3
https://doi.org/10.1016/j.chom.2021.04.005