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Akademický článek

Mechanisms of immune regulation and transplantation immunity in corneal transplants

Autor: V. V. Neroev, N. V. Balatskaya, E. V. Chentsova, Kh. M. Shamkhalova

Publikováno v: Медицинская иммунология, Vol 22, Iss 1, Pp 61-76 (2020)

At the present time, corneal transplantation (keratoplasty) is one of the most frequent modes of solid tissue transplants in the world. Unlike other kinds of transplants, corneal grafting is often performed without tissue typing and systemic immunosu

Externí odkaz: https://doaj.org/article/0f2234fc05a84e7bbb36b7ef3b2d9798

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Akademický článek

Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient

Autor: Deniz Hos, Friederike Schaub, Claus Cursiefen

Publikováno v: BMC Ophthalmology, Vol 19, Iss 1, Pp 1-3 (2019)

Abstract Background It has been shown experimentally in rodents that removal of the spleen leads to increased rejection of corneal allografts after corneal transplantation (keratoplasty). Case presentation Here, we report a unique case of a splenecto

Externí odkaz: https://doaj.org/article/2173be38eaf74a87be53e94f92d51af0

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Akademický článek

Type II Collagen-Specific B Cells Induce Immune Tolerance in Th1-Skewed, Th2-Skewed, and Arthritis-Prone Strains of Mice

Autor: Shukkur M. Farooq, Hossam M. Ashour

Publikováno v: Cells, Vol 10, Iss 4, p 870 (2021)

Antigen-specific regulatory T cells play key immune suppressive roles in autoimmune disease models and regulate the peripheral tolerance achieved via anterior chamber-associated immune deviation (ACAID). Articular cartilage has type II collagen (CII)

Externí odkaz: https://doaj.org/article/e7dbd9c4c3ec416f86d80041131a9073

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Akademický článek

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Akademický článek

Cellular and Molecular Mechanisms of Anterior Chamber-Associated Immune Deviation (ACAID): What We Have Learned from Knockout Mice

Autor: Julie Vendomèle, Quentin Khebizi, Sylvain Fisson

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Anterior chamber-associated immune deviation (ACAID) is a well-known phenomenon that can occur after an antigen is introduced without any danger signal into the anterior chamber of a murine eye. It is reported to lead to an antigen-specific immune de

Externí odkaz: https://doaj.org/article/0a0ce0f775134804bb899b1d7ced4844

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Animal models of high-risk corneal transplantation: a comprehensive review

Autor: Anna Marmalidou, Rohan Bir Singh, Yihe Chen, Afsaneh Amouzegar, Reza Dana

Publikováno v: Exp Eye Res

Over the past century, corneal transplantation has become the most commonly performed allogeneic solid tissue transplantation. Although more than 80% of the corneal transplantations have favorable outcomes, immune-mediated rejection continues to be t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4b619425b63576fc90be278c24ccf7
https://hdl.handle.net/1887/3627213

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Akademický článek

Influence of CD8+ T regulatory Cells on Intraocular Tumor Development

Autor: Kyle C McKenna, Dana Michelle Previte

Publikováno v: Frontiers in Immunology, Vol 3 (2012)

The interior of the eye, or uvea, is a site of immune privilege where certain immune responses are attenuated or completely excluded to protect non regenerating tissues essential for vision. One consequence of this immunoregulation is compromised imm

Externí odkaz: https://doaj.org/article/eb1d92066b1c4231b7e49ba4d4bd3a8e

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Re-programming immunosurveillance in persistent non-infectious ocular inflammation

Autor: Epps, Simon J., Boldison, Joanne, Stimpson, Madeleine L., Khera, Tarnjit K., Lait, Philippa J.P., Copland, David A., Dick, Andrew D., Nicholson, Lindsay B.

Publikováno v: Progress in Retinal and Eye Research
Epps, S J, Boldison, J, Stimpson, M L, Khera, T K, Lait, P J P, Copland, D A, Dick, A D & Nicholson, L B 2018, ' Re-programming immunosurveillance in persistent non-infectious ocular inflammation ', Progress in Retinal and Eye Research, vol. 65, pp. 93-106 . https://doi.org/10.1016/j.preteyeres.2018.03.001

Ocular function depends on a high level of anatomical integrity. This is threatened by inflammation, which alters the local tissue over short and long time-scales. Uveitis due to autoimmune disease, especially when it involves the retina, leads to pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a49bd81f645d9d5352fa5b075e94d71b
http://europepmc.org/articles/PMC6563519

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