Zobrazeno 1 - 10
of 6 587
pro vyhledávání: '"ABCB1"'
Autor:
Sazanami Mori, Natsuki Nakamura, Ayane Fuchigami, Satoshi Yoshimoto, Moe Sakakibara, Toshiyuki Ozawa, Junken Aoki, Asuka Inoue, Hayakazu Sumida, Hideya Ando, Motonao Nakamura
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 10, Pp 424-441 (2024)
Abstract Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non‐taste perception and tissue‐specific functions. Keratinocytes that express TAS2Rs in the skin
Externí odkaz:
https://doaj.org/article/87f2088083af4c1389595ee070e7630c
Autor:
Da Wang, Junsheng Chen, Guanhua Wu, Fei Xiong, Wenzheng Liu, Qi Wang, Yiyang Kuai, Wenhua Huang, Yongqiang Qi, Bing Wang, Ruizhi He, Yongjun Chen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Cholangiocarcinoma (CCA) is a highly malignant, rapidly progressing tumor of the bile duct. Owing to its chemoresistance, it always has an extremely poor prognosis. Therefore, detailed elucidation of the mechanisms of chemoresista
Externí odkaz:
https://doaj.org/article/1bad50f6a60849b79a8adb98f1b8a30b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2548-2564 (2024)
P-glycoprotein (P-gp) plays a crucial role in cellular detoxification and drug efflux processes, transitioning between inward-facing (IF) open, occluded, and outward-facing (OF) states to facilitate substrate transport. Its role is critical in cancer
Externí odkaz:
https://doaj.org/article/a89cc4aff34b495182c4b60c28beb7de
Autor:
Franziska Maria Schwarz, Jan Dominik Kuhlmann, Jorrin Kämpfer, Anna Klimova, Daniel Martin Klotz, Lisa Freitag, Pia Herrmann, Viktoria Zinnow, Janice Smith, Theresia Scheller, Wolfgang Walther, Pauline Wimberger, Ulrike Stein
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)
Abstract The drug efflux transporter P-glycoprotein, encoded by the ABCB1 gene, promotes acquired chemoresistance. We explored the presence and clinical relevance of circulating cell-free ABCB1 transcripts (cfABCB1tx) in ovarian cancer patients (173
Externí odkaz:
https://doaj.org/article/bbbc1b0b2f144c9cb8c3f0c9409951ea
Autor:
Aristeidis Lentzas, Mark C. de Gooijer, Stefanie Zuidema, Amber Meurs, Ceren H. Çitirikkaya, Nikkie Venekamp, Jos H. Beijnen, Olaf van Tellingen
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Pharmacotherapy for brain diseases is severely compromised by the blood-brain barrier (BBB). ABCB1 and ABCG2 are drug transporters that restrict drug entry into the brain and their inhibition can be used as a strategy to boost dru
Externí odkaz:
https://doaj.org/article/57eb6677d2ba47b88093983f8eec384d
Autor:
Adel I. Alalawy
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Paclitaxel is commonly used to treat breast, ovarian, lung, esophageal, gastric, pancreatic cancer, and neck cancer cells. Cancer recurrence is observed in patients treated with paclitaxel due to paclitaxel resistance emergence. Resistant me
Externí odkaz:
https://doaj.org/article/b4806cd466ac429182aeaa58441ddf8c
Autor:
Rakhmad Hidayat, Rizqi Amanda Nabilah, Marc Fisher, Tiara Aninditha, Mohammad Kurniawan, Riwanti Estiasari, Luh Ari Indrawati, Ahmad Yanuar Safri, Taufik Mesiano, Al Rasyid, Salim Harris
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Clopidogrel has been the primary choice of antiplatelet in ischemic stroke that inhibits adenosine diphosphate (ADP)-induced platelet aggregation. P-glycoprotein (P-gp) multidrug resistance-1 (MDR1) is a transmembrane efflux trans
Externí odkaz:
https://doaj.org/article/f015b7f45a6d4c48a8dd437599095e33
Autor:
Zhuan Yang, Wen Rui Tan, Qin Li, Ying Wang, Shijing Liu, Lu Chen, Yan Zhou, Chen Zeng, Yan Zeng, Yun Xiong, Qian Zhang, Na Li, Peng Du, Lin Liu, Jiyu Chen, Yan He
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
PurposeThe impact of genetic polymorphisms in the ABCB1 and CES1 genes on dabigatran plasma concentrations remains a subject of debate, and the purpose of this study was to quantitatively assess the effects of genetic polymorphisms on dabigatran este
Externí odkaz:
https://doaj.org/article/55473f1fd6004142b1910badba338dcc
Autor:
Bing-Huan Lin, Yen-Ching Li, Megumi Murakami, Yu-Shan Wu, Yang-Hui Huang, Tai-Ho Hung, Suresh.V. Ambudkar, Chung-Pu Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117542- (2024)
A significant hurdle in cancer treatment arises from multidrug resistance (MDR), often due to overexpression of ATP-binding cassette (ABC) transporters like ABCB1 and/or ABCG2 in cancer cells. These transporters actively diminish the efficacy of cyto
Externí odkaz:
https://doaj.org/article/704b71edd5c043f7a3fb501d725d7c37