Zobrazeno 1 - 10
of 8 214
pro vyhledávání: '"ABC-transporters"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2548-2564 (2024)
P-glycoprotein (P-gp) plays a crucial role in cellular detoxification and drug efflux processes, transitioning between inward-facing (IF) open, occluded, and outward-facing (OF) states to facilitate substrate transport. Its role is critical in cancer
Externí odkaz:
https://doaj.org/article/a89cc4aff34b495182c4b60c28beb7de
Publikováno v:
Redox Experimental Medicine, Vol 2024, Iss 1, Pp 1-8 (2024)
Objective: We tested the effect of 27-hydroxycholesterol (27OHC) on the expression and synthesis of two membrane transporters involved in sterols extrusion from the intestinal epithelium into the gut lumen: ATP-binding cassette A1 (ABCA1) and G8 (ABC
Externí odkaz:
https://doaj.org/article/7d8b854bdc9c42b8b4ec255345fd2b62
Autor:
Qihong Yang, Kenneth Kin Wah To, Guilin Hu, Kai Fu, Chuan Yang, Shuangli Zhu, Can Pan, Fang Wang, Kewang Luo, Liwu Fu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will investigate the effect
Externí odkaz:
https://doaj.org/article/c9a04ec7abd14125a58f4cf6990b7266
Autor:
Caitlin E. Moss, Craig R. Roy
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Legionella pneumophila is an intracellular bacterial pathogen that replicates inside human alveolar macrophages to cause a severe pneumonia known as Legionnaires’ disease. L. pneumophila requires the Dot/Icm Type IV secretion system to del
Externí odkaz:
https://doaj.org/article/847fd50673e148679d991028695cc277
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 96, Iss suppl 1 (2024)
Abstract We aimed to find new therapeutic targets related to Cancer Stem Cell alterations in recurrent patients from two TCGA cohorts: Testicular Germ Cell Tumor (TGCT) and Uterine Corpus Endometrial Carcinoma (UCEC). Raw sequencing data were downloa
Externí odkaz:
https://doaj.org/article/9479b84978a147caa3b5d31f3379c1e9
Autor:
S. V. Boichuk, T. V. Ivoilova
Publikováno v:
Успехи молекулярной онкологии, Vol 11, Iss 1, Pp 8-21 (2024)
ABC transporters (ATP Binding Cassette (ABC) transporters) are proteins, which play a dual role in the substances transport across the membrane. On the one hand, they transport nutrients and other molecules inside the cell to supply the necessary nut
Externí odkaz:
https://doaj.org/article/2e1619614e244037823fdeaa6a1e4288
Publikováno v:
Thoracic Cancer, Vol 15, Iss 10, Pp 820-829 (2024)
Abstract Background N‐acetyltransferase 10 (NAT10) serves as a critical enzyme in mediating the N4‐acetylcytidine (ac4C) that ensures RNA stability and effective translation processes. The role of NAT10 in driving the advancement of breast cancer
Externí odkaz:
https://doaj.org/article/1794259c33cc450b874f64ee7cca54ba
Autor:
Mariko Kotono, Toshiki Kijima, Atsuko Takada‐Owada, Naoya Okubo, Ryo Kurashina, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Kazuyuki Ishida, Takao Kamai
Publikováno v:
IJU Case Reports, Vol 7, Iss 2, Pp 173-176 (2024)
Introduction In addition to reduced nectin‐4 expression, the upregulation of ATP‐binding cassette transporters has been suggested as a potential mechanism of resistance to enfortumab vedotin. Case presentation A 76‐year‐old man previously tre
Externí odkaz:
https://doaj.org/article/63bcc92766b349b79fab938d17d6b54a
Publikováno v:
Journal of Plant Interactions, Vol 19, Iss 1 (2024)
In the current study the metabolic response of peanut root exudates to Sclerotium rolfsii Sacc. infection was analyzed in plant-pathogen interaction systems. The analytical methodology employed in this study entailed the utilization of ultra-high-per
Externí odkaz:
https://doaj.org/article/5c028f01c63a44c8b244c4a02ceb69e4