Zobrazeno 1 - 10
of 10 753
pro vyhledávání: '"ABC transporter"'
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 7, Pp 594-599 (2024)
The ATP-binding cassette (ABC) transporter superfamily comprises membrane proteins that efflux various substrates across extra- and intracellular membranes. Among them, ABCB1, ABCG2, and ABCC1 are directly linked to tumor multidrug resistance (MDR).
Externí odkaz:
https://doaj.org/article/a8107902d04d428483c3790fea6cf0a1
Autor:
Xiao Li, Zhen Zheng, Wanzhen Zhou, Huixian Huang, Yang Zhou, Qinyang Xu, Xiaolu Zhu, Yincheng Teng
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Ovarian cancer (OV) is a highly fatal malignant disease that commonly manifests at an advanced stage. Drug resistance, particularly platinum resistance, is a leading cause of treatment failure because first-line systemic chemotherapy primari
Externí odkaz:
https://doaj.org/article/f6ae17dbebe44a009c974bd8e56cdd36
Autor:
M. Melet, S. Blanchet, P. Barbarin, E. A. Maunders, S. L. Neville, V. Rong, L. Mereghetti, C. A. McDevitt, A. Hiron
Publikováno v:
mSphere, Vol 9, Iss 11 (2024)
ABSTRACT Zinc (Zn) is an essential cofactor for numerous bacterial proteins and altering Zn availability is an important component of host innate immunity. During infection, adaptation to both Zn deprivation and excess is critical for pathogenic bact
Externí odkaz:
https://doaj.org/article/9e0c7193687048349d8c4f1030bd975e
Autor:
Yuejia Chen, Du Guo, Xin Wang, Changbin Zhang, Yatian Chen, Qinghua Luo, Yujiao Chen, Lili Yang, Zhibo Zhang, Tian Hong, Zhengyu Zhang, Haohao Dong, Shenghai Chang, Jianping Hu, Xiaodi Tang
Publikováno v:
MedComm, Vol 5, Iss 11, Pp n/a-n/a (2024)
Abstract The filamentous temperature‐sensitive (Fts) protein FtsEX plays a pivotal role in Escherichia coli (E. coli) cell division by facilitating the activation of peptidoglycan hydrolysis through the adaptor EnvC. FtsEX belongs to the type VII A
Externí odkaz:
https://doaj.org/article/1217d081d0d04c89b4fa30fb5ecf0160
Autor:
Bing-Huan Lin, Yen-Ching Li, Megumi Murakami, Yu-Shan Wu, Yang-Hui Huang, Tai-Ho Hung, Suresh.V. Ambudkar, Chung-Pu Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117542- (2024)
A significant hurdle in cancer treatment arises from multidrug resistance (MDR), often due to overexpression of ATP-binding cassette (ABC) transporters like ABCB1 and/or ABCG2 in cancer cells. These transporters actively diminish the efficacy of cyto
Externí odkaz:
https://doaj.org/article/704b71edd5c043f7a3fb501d725d7c37
Autor:
Yen-Ching Li, Yun-Chieh Lee, Megumi Murakami, Yang-Hui Huang, Tai-Ho Hung, Yu-Shan Wu, Suresh.V. Ambudkar, Chung-Pu Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117554- (2024)
Chemotherapy treatment faces a major obstacle with the emergence of multidrug resistance (MDR), often attributed to the elevated expression of ATP-binding cassette (ABC) transporters such as ABCG2 and ABCB1 in cancer cells. These transporters hinder
Externí odkaz:
https://doaj.org/article/6ab91c456db54964b09cd565d19b7546
Autor:
Ashwin Mahendran, Benjamin J. Orlando
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
ABC transporters are a diverse superfamily of membrane protein complexes that utilize the binding/hydrolysis of ATP to power substrate movement across biological membranes or perform mechanical work. In bacteria, these transporters play essential rol
Externí odkaz:
https://doaj.org/article/2bff059ebd7a47c58d55b824aa3362b5
Autor:
Manuel T. Anlauf, Florestan L. Bilsing, Jens Reiners, Olivia Spitz, Eymen Hachani, Sander H. J. Smits, Lutz Schmitt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Type I secretion systems (T1SS) facilitate the secretion of substrates in one step across both membranes of Gram-negative bacteria. A prime example is the hemolysin T1SS which secretes the toxin HlyA. Secretion is energized by the ABC transp
Externí odkaz:
https://doaj.org/article/a0598cad15ab4e3883050d21aafba132
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background The process of producing proteins in bacterial systems and secreting them through ATP-binding cassette (ABC) transporters is an area that has been actively researched and used due to its high protein production capacity and effici
Externí odkaz:
https://doaj.org/article/5d3664f096aa47c0b74dc1f990637a93
Publikováno v:
Channels, Vol 18, Iss 1 (2024)
ABSTRACTKATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium
Externí odkaz:
https://doaj.org/article/ae5b90c7be9645178e9ac3531c0fa733