Zobrazeno 1 - 10
of 135
pro vyhledávání: '"ABC, ATP binding cassette"'
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6490-6504 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6490-6504 (2021)
Graphical abstract
The adenosine-triphosphate-(ATP)-binding cassette (ABC) transporter ABCA7 is a genetic risk factor for Alzheimer’s disease (AD). Defective ABCA7 promotes AD development and/or progression. Unfortunately, ABCA7 belongs to the
The adenosine-triphosphate-(ATP)-binding cassette (ABC) transporter ABCA7 is a genetic risk factor for Alzheimer’s disease (AD). Defective ABCA7 promotes AD development and/or progression. Unfortunately, ABCA7 belongs to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c495bacbe4f6d5dd1686380857969678
http://europepmc.org/articles/PMC8666613
http://europepmc.org/articles/PMC8666613
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1789-1812 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d001e27a816f9de7d75ff16dd2143ec
http://www.sciencedirect.com/science/article/pii/S2211383520307279
http://www.sciencedirect.com/science/article/pii/S2211383520307279
Autor:
Kenneth K.W. To, Jiang Ma, Stella Chai, Chunyuan Zhang, Chun Yin, Sheng Yao, Xu Wu, Thomas Efferth, Yang Ye, Onat Kadioglu, Ge Lin
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10ca45cdbb87dcf2ef29e5865d5f864
https://doi.org/10.1016/j.apsb.2020.12.021
https://doi.org/10.1016/j.apsb.2020.12.021
Autor:
Samuel A. Sprowls, W. Pentz, Manish Ranjan, A. Gabriele, Brooke N. Kielkowski, Jeffrey S Carpenter, Pushkar Saralkar, Rashi I. Mehta, Paul R. Lockman, Ross Fladeland, Peng Wang, Tasneem Arsiwala, Chris E. Adkins, Kathryn E Blethen, Ali R. Rezai, Umer Najib
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)
The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bce52dd68e77db39bf5423f5169f36
http://europepmc.org/articles/PMC8208897
http://europepmc.org/articles/PMC8208897
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 55-70 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa624bee1b295d3b2a8ea11ea5504c8
http://www.sciencedirect.com/science/article/pii/S2211383520307322
http://www.sciencedirect.com/science/article/pii/S2211383520307322
Autor:
Cristiano Rumio, Fabrizio Marcucci
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Tumor cells often switch from mitochondrial oxidative metabolism to glycolytic metabolism even under aerobic conditions. Tumor cell glycolysis is accompanied by several nonenzymatic activities among which induction of drug resistance has important th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa5b30ce2ee01dd517b432844e879a6
http://europepmc.org/articles/PMC7804361
http://europepmc.org/articles/PMC7804361
Autor:
Peralvarez-Marin, Alex, Baranowski, Eric, Bierge, Paula, Quijada Pich, Oscar, Lebrette, Hugo, Universitat Autònoma de Barcelona. Institut de Neurociències
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5752-5761 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Computational and Structural Biotechnology Journal
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Computational and Structural Biotechnology Journal
Graphical abstract
Mycoplasmas are parasitic bacteria with streamlined genomes and complex nutritional requirements. Although iron is vital for almost all organisms, its utilization by mycoplasmas is controversial. Despite its minimalist nature,
Mycoplasmas are parasitic bacteria with streamlined genomes and complex nutritional requirements. Although iron is vital for almost all organisms, its utilization by mycoplasmas is controversial. Despite its minimalist nature,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885c73de0bbf4a6c5d726836729609e4
http://www.sciencedirect.com/science/article/pii/S200103702100444X
http://www.sciencedirect.com/science/article/pii/S200103702100444X
Publikováno v:
Pharmaceutics, Vol 3, Iss 4, Pp 680-705 (2011)
Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs. Alterations of drug transport due to co
Externí odkaz:
https://doaj.org/article/2e170b9da8404e53bd4044ca267edc0c
Autor:
Darcie D. Seachrist, Jessica R. Bobbitt, Bryan M. Webb, Lindsey J. Anstine, Eduardo Williams-Medina, Ruth A. Keri, Benjamin L. Bryson
Publikováno v:
The Journal of Biological Chemistry
Cyclin-dependent kinase 7 (CDK7) is a master regulatory kinase that drives cell cycle progression and stimulates expression of oncogenes in a myriad of cancers. Inhibitors of CDK7 (CDK7i) are currently in clinical trials; however, as with many cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0fcb6411ba98a52f1474b185da1ab4
http://europepmc.org/articles/PMC8498470
http://europepmc.org/articles/PMC8498470
Autor:
Matthew E. Cramp, Mohamed I.F. Shariff, Munirah Alsaleh, Thomas A Barbera, Yi-Liang Shen, Puangrat Yongvanit, Simon D. Taylor-Robinson, Elaine Holmes, Shaun Greer, Mary M.E. Crossey, Larry K. Koomson, Stephen D. Ryder, Paiboon Sithithaworn, Watcharin Loilome, Abigail Zabron, Christopher A. Wadsworth, Kathryn Nash, Martin Prince, Zoe Leftley, Narong Khuntikeo, Helen L. Reeves, I. Jane Cox, Roger Williams
Publikováno v:
J Clin Exp Hepatol
Background A distinct serum metabonomic pattern has been previously revealed to be associated with various forms of liver disease. Here, we aimed to apply mass spectrometry to obtain serum metabolomic profiles from individuals with cholangiocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85129a29e0c43020b860a1bb8a79bdd9
https://doi.org/10.1016/j.jceh.2019.06.001
https://doi.org/10.1016/j.jceh.2019.06.001