Phase 1 tolerability and antiamoebic activity studies with 1-methylsulphonyl-3-(1-methyl-5-nitro-2-imidazolyl)-2-imidazolidinone (Go.10213): a new antiprotozoal agent

Autor: NA Mankodi, DK Ray, Sheth Uk, AB Vaidya, Paul T

Publikováno v: British journal of clinical pharmacology. 16(5)

Go.10213, a new nitroimidazole, was studied in 12 male volunteers for tolerability and in 20 patients with intestinal amoebiasis for antiamoebic activity. Go.10213 was well-tolerated by volunteers up to a dose of 400 mg X 3. Patients also tolerated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf45ae061a21646c95f100965c1525c
https://pubmed.ncbi.nlm.nih.gov/6639838

Evaluation of Withania somnifera (L.) Dunal (Ashwagandha) on Physical Performance, Biomarkers of Inflammation, and Muscle Status in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study.

Autor: Raut A; Clinical Research and Integrative Medicine Department, Kasturba Health Society, Medical Research Centre, Mumbai, IND., Tripathi R; Pharmacology and Therapeutics Department, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, IND., Marathe PA; Pharmacology and Therapeutics Department, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, IND., Uchil DA; Pharmacology and Therapeutics Department, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, IND., Agashe S; Clinical and Endocrine Laboratory, Kasturba Health Society, Medical Research Centre, Mumbai, IND., Rege N; Pharmacology and Therapeutics Department, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, IND., Vaidya AB; Internal Medicine Department, Kasturba Health Society, Medical Research Centre, Mumbai, IND.

Publikováno v: Cureus [Cureus] 2024 Sep 08; Vol. 16 (9), pp. e68940. Date of Electronic Publication: 2024 Sep 08 (Print Publication: 2024).

3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance.

Autor: Pou S; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Winter RW; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Dodean RA; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Liebman K; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Li Y; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Mather MW; Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States., Nepal B; Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States., Nilsen A; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Handford MJ; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Riscoe TM; Department of Microbiology and Molecular Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Laxson S; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Kirtley PJ; Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States., Aleshnick M; Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States., Zakharov LN; Center for Advanced Materials Characterization in Oregon (CAMCOR), 1443 E. 13th Avenue, Eugene, Oregon 97403, United States., Kelly JX; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Smilkstein MJ; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Wilder BK; Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States., Kortagere S; Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States., Vaidya AB; Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States., Alday PH; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; School of Medicine Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Doggett JS; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; School of Medicine Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Riscoe MK; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; Department of Microbiology and Molecular Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Jul 12; Vol. 10 (7), pp. 2419-2442. Date of Electronic Publication: 2024 Jun 11.

Inducing indigestion in malaria parasites: Genetic manipulations of a proton pump.

Autor: Vaidya AB; Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Aug 22; Vol. 120 (34), pp. e2310870120. Date of Electronic Publication: 2023 Aug 09.

Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors.

Autor: Tewari SG; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD, USA. stewari@bhsai.org.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA. stewari@bhsai.org., Elahi R; Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, USA., Kwan B; Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, USA., Rajaram K; Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, USA., Bhatnagar S; Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Reifman J; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD, USA., Prigge ST; Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, USA., Vaidya AB; Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA., Wallqvist A; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD, USA. sven.a.wallqvist.civ@health.mil.

Publikováno v: Malaria journal [Malar J] 2023 Feb 14; Vol. 22 (1), pp. 56. Date of Electronic Publication: 2023 Feb 14.