OX40 and 4-1BB delineate distinct immune profiles in sarcoma

Autor: MJ Melake, HG Smith, D Mansfield, E Davies, MT Dillon, AC Wilkins, EC Patin, M Pedersen, R Buus, AA Melcher, K Thway, AB Miah, SH Zaidi, AJ Hayes, TR Fenton, KJ Harrington, M McLaughlin

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Systemic relapse after radiotherapy and surgery is the major cause of disease-related mortality in sarcoma patients. Combining radiotherapy and immunotherapy is under investigation as a means to improve response rates. However, the immune contexture

Externí odkaz: https://doaj.org/article/81afcd7101924da99decc87c750acf06

Role of electron and hole doping in the NdNi 1- x V x O 3 nanostructure.

Autor: Basu R; National Centre for High Pressure Studies, Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur 741246, Nadia, West Bengal, India. Raktimabasu14@gmail.com., Kumawat R; National Centre for High Pressure Studies, Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur 741246, Nadia, West Bengal, India. Raktimabasu14@gmail.com., Sahu M; National Centre for High Pressure Studies, Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur 741246, Nadia, West Bengal, India. Raktimabasu14@gmail.com., Miah AB; Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur 741246, Nadia, West Bengal, India., Mitra P; Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur 741246, Nadia, West Bengal, India., Mukherjee GD; National Centre for High Pressure Studies, Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur 741246, Nadia, West Bengal, India. Raktimabasu14@gmail.com.

Publikováno v: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2023 Nov 29; Vol. 25 (46), pp. 31741-31746. Date of Electronic Publication: 2023 Nov 29.

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.

Autor: Callegaro D; Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Raut CP; Department of Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Ajayi T; Department of Statistics, European Organisation for Research and Treatment of Cancer, Brussels, Belgium., Strauss D; Department of General Surgery, Royal Marsden NHS Foundation Trust, London, UK., Bonvalot S; Department of Surgery, Institute Curie, University of Paris, Paris, France., Ng D; Department of Surgical Oncology, Princess Margaret Cancer Center/Mount Sinai Hospital, Toronto, ON, Canada.; Department of Surgery, University of Toronto, Toronto, ON, Canada., Stoeckle E; Department of Surgery, Institut Bergonie, Bordeaux, France., Fairweather M; Department of Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Rutkowski P; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., van Houdt WJ; Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands., Sangalli C; Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Hayes A; Department of General Surgery, Royal Marsden NHS Foundation Trust, London, UK., Honoré C; Department of Surgical Oncology, Institut Gustave Roussy, Villejuif, France., Gladdy RA; Department of Surgical Oncology, Princess Margaret Cancer Center/Mount Sinai Hospital, Toronto, ON, Canada., Fau M; Department of Surgery, University of Toronto, Toronto, ON, Canada., Haas R; Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Radiotherapy, Leiden University Medical Center, Leiden, The Netherlands., Tzanis D; Department of Surgery, Institute Curie, University of Paris, Paris, France., Miah AB; Department of Radiation Oncology, Royal Marsden NHS Foundation Trust, and The Institute of Cancer Research, London, UK., Chung P; Department of Radiation Oncology, Princess Margaret Cancer Center/Mount Sinai Hospital, Toronto, ON, Canada.; Department of Surgery, University of Toronto, Toronto, ON, Canada., Baldini EH; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Marreaud S; European Organisation for Research and Treatment of Cancer, Brussels, Belgium., Litiere S; Department of Statistics, European Organisation for Research and Treatment of Cancer, Brussels, Belgium., Swallow CJ; Department of Surgical Oncology, Princess Margaret Cancer Center/Mount Sinai Hospital, Toronto, ON, Canada., Gronchi A; Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Publikováno v: Annals of surgery [Ann Surg] 2023 Jul 01; Vol. 278 (1), pp. 127-134. Date of Electronic Publication: 2022 Jul 14.

Controversies in the management of patients with soft tissue sarcoma: Recommendations of the Conference on State of Science in Sarcoma 2022.

Autor: Rothermundt C; Department of Medical Oncology and Haematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland. Electronic address: christian.rothermundt@kssg.ch., Andreou D; Department of Orthopedics and Trauma, Medical University of Graz, Graz, Austria., Blay JY; Department of Medicine, Léon Bérard Center, Lyon, France., Brodowicz T; Department of Medical Oncology, General Hospital - Medical University of Vienna, Vienna, Austria., Desar IME; Department of Medical Oncology, Radboud University Medical Center Nijmegen, the Netherlands., Dileo P; London Sarcoma Service, Department of Oncology, University College Hospital London, United Kingdom., Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Haas R; Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam and the Leiden University Medical Center, Leiden, the Netherlands., Jakob J; Sarcoma Unit, Department of Surgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany., Jones RL; Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Judson I; The Institute of Cancer Research, London, United Kingdom., Kunz WG; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Liegl-Atzwanger B; Diagnostic and Research Institute of Pathology, Medical University Graz, Graz, Austria., Lindner LH; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany., Messiou C; Department of Radiology, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom., Miah AB; Department of Radiotherapy, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom., Reichardt P; Department of Oncology and Palliative Care, Helios Klinikum Berlin-Buch, Berlin, Germany., Szkandera J; Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., van der Graaf WTA; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., van Houdt WJ; Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Wardelmann E; Gerhard-Domagk-Institute of Pathology, University Hospital Muenster, Muenster, Germany., Hofer S; Department of Neurology, University Hospital Zurich, Zurich, Switzerland.

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2023 Feb; Vol. 180, pp. 158-179. Date of Electronic Publication: 2022 Nov 16.

Retrospective observational studies in ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society (CTOS) community of experts on the minimum requirements for the evaluation of activity of systemic treatments.

Autor: Stacchiotti S; Department of Medical Oncology, IRCCS Fondazione Istituto Nazionale Tumori (INT), 20133 Milan, Italy. Electronic address: silvia.stacchiotti@istitutotumori.mi.it., Maria Frezza A; Department of Medical Oncology, IRCCS Fondazione Istituto Nazionale Tumori (INT), 20133 Milan, Italy., Demetri GD; Department of Medical Oncology, Sarcoma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Blay JY; Department of Medicine, Centre Léon Bérard, Université Claude Bernard Lyon I, Unicancer, 69008 Lyon, France., Bajpai J; Medical Oncology Department, Tata Memorial Centre, Homi Bhabha National Institute, 400012 Mumbai, India., Baldi GG; Department of Medical Oncology, Ospedale Santo Stefano, 59100, Prato, Italy., Baldini EH; Department of Radiation Oncology, Dana-Farber Cancer Institute/ Brigham and Women's Hospital, Boston 02215, MA, USA., Benjamin RS; Department of Sarcoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, TX, USA., Bonvalot S; Department of Surgical Oncology, Institut Curie, Université Paris Sciences et Lettres, 75005, France., Bovée JVMG; Departmen of Pathology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Callegaro D; Department of Surgery, INT, 20133 Milan, Italy., Casali PG; Department of Medical Oncology, IRCCS Fondazione Istituto Nazionale Tumori (INT), 20133 Milan, Italy., D'Angelo SP; Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, 10065, New York, NY, USA., Davis EJ; Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Dei Tos AP; Department of Pathology, Azienda Ospedaliera Università Padova, 35129, Padova, Italy., Demicco EG; Department of Laboratory Medicine and Pathobiology, University of Toronto & Pathology and Laboratory Medicine Mount Sinai Hospital, ON M5G 1X5, Toronto, Canada., Desai J; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne VIC 3000, Australia., Dileo P; Soft tissue and bone sarcoma service, University College Hospital, UCLH NHS Trust, NW1 2BU, London, United Kingdom., Eriksson M; Department of Oncology, Skåne University Hospital, and Lund University, 222 42, Lund, Sweden., Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., George S; Department of Medical Oncology, Sarcoma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Gladdy RA; Mount Sinai Hospital, Princess Margaret Hospital, University of Toronto, ON M5G 1X5, Toronto, ON, Canada., Gounder MM; Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, 10065, New York, NY, USA., Gupta AA; The Hospital for Sick Children and Princess Margaret Cancer Center, University of Toronto, ON M5G 2C1, Toronto, Canada., Haas R; Department of Radiotherapy, the Netherlands Cancer Institute, 1066 CX, Amsterdam and the Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Hayes A; Department of Surgery, the Royal Marsden NHS Foundation Trust, SW3 6JJ, London, United Kingdom., Hohenberger P; Division of Surgical Oncology and Thoracic Surgery, Mannheim University Medical Center, Medical Faculty Mannheim, University of Heidelberg, 69117 Heidelberg, Germany., Jones KB; Departments of Orthopaedics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, UT 84112, Salt Lake City, USA., Jones RL; Sarcoma Unit, the Royal Marsden NHS Foundation Trust and Institute of Cancer Research, SW3 6JJ, London, United Kingdom., Kasper B; Sarcoma Unit, Mannheim Cancer Center (MCC), Mannheim University Medical Center, University of Heidelberg, 68167 Mannheim, Germany., Kawai A; Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan., Kirsch DG; Department of Radiation Oncology, Duke University Medical Center, NC 27710 Durham, USA., Kleinerman ES; Division of Pediatrics, University of Texas M.D. Anderson Cancer Center, 77030 Huston, TX, USA., Le Cesne A; Medical Oncology, Insitut Gustave Roussy, 94805 Villejuif, Ile-de-France, France., Maestro R; Unit of Oncogenetics and Functional Oncogenomics, 33081 Aviano, Italy., Martin Broto J; Medical Oncology Department, University Hospital Fundacion Jimenez Diaz, University Hospital General de Villalba and Instituto de Investigacion Sanitaria FJD, 28040 Madrid, Spain., Maki RG; Abramson Cancer Center, University of Pennsylvania, 19104 Philadelphia, PA, USA., Miah AB; Department of Radiation Therapy, the Royal Marsden NHS Foundation Trust, SW3 6JJ, London, United Kingdom., Palmerini E; Osteoncology, Soft Tissue and Bone Sarcoma and Innovative Therapy Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy., Patel SR; Department of Sarcoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, TX, USA., Raut CP; Department of Surgery, Brigham and Women's Hospital, Center for Sarcoma and Bone Oncology, DFCC, Harvard Medical School, Boston 02215, MA, USA., Razak ARA; Princess Margaret Cancer Center, ON M5G 2C1, Toronto, Canada., Reed DR; Department of Individualized Cancer Management, Moffitt Cancer Center, FL 33612, Tampa, FL, USA., Rutkowski P; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 00-001, Warsaw, Poland., Sanfilippo RG; Department of Medical Oncology, IRCCS Fondazione Istituto Nazionale Tumori (INT), 20133 Milan, Italy., Sbaraglia M; Department of Pathology, Azienda Ospedaliera Università Padova, 35129, Padova, Italy., Schaefer IM; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA 02215, Boston, MA, USA., Strauss DC; Department of Surgery, The Royal Marsden Hospital and The Institute of Cancer Research, SW3 6JJ, London, the United Kingdom of Great Britain and Northern Ireland., Strauss SJ; Soft tissue and bone sarcoma service, University College Hospital, UCLH NHS Trust, NW1 2BU, London, United Kingdom., Tap WD; Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, 10065, New York, NY, USA., Thomas DM; Garvan Institute of Medical Research, NSW 2010, Sydney, Australia., Trama A; Department of Research, Evaluative Epidemiology Unit, INT, 20133 Milan, Italy., Trent JC; Sylvester Comprehensive Cancer Center, University of Miami, 33136 Miami, FL, USA., van der Graaf WTA; Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands., van Houdt WJ; Department of Surgical Oncology, the Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands., von Mehren M; Department of Hematology and Oncology, Fox Chase Cancer Center, 19111 Philadelphia, PA, USA., Wilky BA; Department of Medical Oncology, University of Colorado Cancer Center, 80045 Aurora, CO, USA., Fletcher CDM; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA 02215, Boston, MA, USA., Gronchi A; Department of Surgery, INT, 20133 Milan, Italy., Miceli R; Unit of Clinical Epidemiology and Trial Organization, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy., Wagner AJ; Department of Medical Oncology, Sarcoma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

Publikováno v: Cancer treatment reviews [Cancer Treat Rev] 2022 Nov; Vol. 110, pp. 102455. Date of Electronic Publication: 2022 Aug 18.