Zobrazeno 1 - 10
of 190
pro vyhledávání: '"AAVS1"'
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 6, Pp n/a-n/a (2024)
Abstract Self‐organizing brain organoids provide a promising tool for studying human development and disease. Here we created human forebrain organoids with stable and homogeneous expression of channelrhodopsin‐2 (ChR2) by generating AAVS1 safe h
Externí odkaz:
https://doaj.org/article/3339dace59ea4b5cb867f990d47bb401
Autor:
Tae Hyeong Kim, Seong-Wook Lee
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101151- (2023)
Hepatitis C virus (HCV) infections frequently recur after liver transplantation in patients with HCV-related liver diseases. Approximately 30% of these patients progress to cirrhosis within 5 years after surgery. In this study, we proposed an effecti
Externí odkaz:
https://doaj.org/article/83cac53e924c4d3daba501d42e01995a
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 107-118 (2022)
Genomic safe harbors (GSH) are defined as sites in the host genome that allow stable expression of inserted transgenes while having no adverse effects on the host cell, making them ideal for use in basic research and therapeutic applications. Silenci
Externí odkaz:
https://doaj.org/article/ba4cc8c6271b472db29d5ef2822f7a11
Akademický článek
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Autor:
Forough Shams, Hamideh Moravvej, Simzar Hosseinzadeh, Bahram Kazemi, Masoumrh Rajabibazl, Azam Rahimpour
Publikováno v:
BioImpacts, Vol 12, Iss 3, Pp 219-231 (2022)
Introduction: Migration of fibroblast cells in wound areas is a critical aspect of the wound healing process. Employment of enhanced green fluorescent protein (EGFP) labeled fibroblast cells facilitates real-time monitoring and functional evaluation
Externí odkaz:
https://doaj.org/article/e2c6903e64a744f692dde1a151763d41
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Background Redirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is attractive in developing off-the-shelf CAR therapeutics for cancer treatment. However, the site-specific integration of a CAR gene into NK cells rem
Externí odkaz:
https://doaj.org/article/d1ce988184354b54b4107b2f9529c336
Autor:
Fangfang Zhang, Anna B. Meier, Christine M. Poch, Qinghai Tian, Stefan Engelhardt, Daniel Sinnecker, Peter Lipp, Karl-Ludwig Laugwitz, Alessandra Moretti, Tatjana Dorn
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) represent an excellent in vitro model in cardiovascular research. Changes in their action potential (AP) dynamics convey information that is essential for disease modelin
Externí odkaz:
https://doaj.org/article/3983d8c6541148788af20a72601fb1c1
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 11, Pp 1378-1388 (2020)
Abstract Human pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells, hold great promise for cell‐based therapies, but safety concerns that complicate consideration for routine clinical use remain. Instal
Externí odkaz:
https://doaj.org/article/45ae7e2babc84ed08a807db73aab8c50
Autor:
Wei Jiang, Wei Lian, Jieting Chen, Wenlei Li, Jieyong Huang, Baoyu Lai, Lingyun Li, Zhong Huang, Jianyong Xu
Publikováno v:
BioTechniques, Vol 66, Iss 5, Pp 231-234 (2019)
Mesenchymal stem cells (MSCs) have been intensively investigated and widely applied in regenerative medicine and immune modulation. However, their efficacy declines during the aging or disease process. Thus, genome-edited MSCs with over-expression or
Externí odkaz:
https://doaj.org/article/773eafce6ac74c6c8e42f28bb783b3f6
Autor:
Kinga Vojnits, Mio Nakanishi, Deanna Porras, Yeonjoon Kim, Zhuohang Feng, Diana Golubeva, Mick Bhatia
Publikováno v:
Molecules, Vol 27, Iss 8, p 2434 (2022)
Application of the CRISPR/Cas9 system to knock in fluorescent proteins to endogenous genes of interest in human pluripotent stem cells (hPSCs) has the potential to facilitate hPSC-based disease modeling, drug screening, and optimization of transplant
Externí odkaz:
https://doaj.org/article/113796d73917474782fdeb01cc581c96