Safety and efficacy of the partial adenosine A1 receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced ejection fraction: a phase IIb, randomized, double-blind, placebo-controlled trial

Autor: Voors, A.A., Bax, J.J., Hernandez, A.F., Wirtz, A.B., Pap, A.F., Ferreira, A.C., Senni, M., Laan, M. van der, Butler, J., PANTHEON Investigators

Publikováno v: European Journal of Heart Failure, 21(11), 1426-1433. WILEY
European Journal of Heart Failure, 21(11), 1426-1433. Wiley
European Journal of Heart Failure. WILEY
European Journal of Heart Failure

Aims: Neladenoson bialanate is a partial adenosine A1 receptor agonist with demonstrated beneficial effects on cardiac function in animal models. We aimed to assess the dose–response effect of neladenoson bialanate on cardiac structure and function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e3b88cd7122fbd3cbf3788b9665190
https://hdl.handle.net/1887/122045

Adenosina e neuroproteção na epilepsia do lobo temporal: da ativação do receptor A1 ao bloqueio do receptor A2A

Autor: Rosim, Fernanda Elisa, Silva, Iara Ribeiro, Persike, Daniele Suzete, Vignoli, Thiago, Fernandes, Maria José da Silva

Publikováno v: Journal of Epilepsy and Clinical Neurophysiology, Volume: 16, Issue: 2, Pages: 64-67, Published: 2010

OBJETIVO: Caracterizar o efeito do bloqueio do receptor A2A pelo SCH58261 na modulação da crise e neuroproteção de áreas cerebrais vulneráveis à lesão por pilocarpina. O efeito do SCH58261 foi também analisado em combinação com a ativaçã

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______608::1ab256ea91ea2a7b55967a960b73b025
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492010000200005&lng=en&tlng=en

Structure–affinity relationships of 5′-aromatic ethers and 5′-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents

Autor: Morrison, Christopher F. ^{a, ∗}, Elzein, Elfatih ^a, Jiang, Bob ^a, Ibrahim, Prabha N. ^a, Marquart, Timothy ^a, Palle, Venkata ^a, Shenk, Kevin D. ^a, Varkhedkar, Vaibhav ^a, Maa, Tenning ^b, Wu, Lin ^b, Wu, Yuzhi ^b, Zeng, Dewan ^b, Fong, Irving ^c, Lustig, David ^c, Leung, Kwan ^c, Zablocki, Jeff A. ^a

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 16 July 2004 14(14):3793-3797

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