Zobrazeno 1 - 10
of 68
pro vyhledávání: '"A.V.P. Mackay"'
Publikováno v:
British journal of clinical pharmacology. 1(5)
1 Blood samples were obtained from eighty-six chronic schizophrenics receiving a wide range of oral doses of chlorpromazine. Plasma concentrations of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulphoxide were estimated using a sensiti
Autor:
A.V.P. Mackay
Publikováno v:
Advances in Psychiatric Treatment. 1:16-22
The dopamine hypothesis for the mode of action of antipsychotic drugs has been with us for some 30 years and has, by and large, withstood the test of time. It simply states that antipsychotic drugs owe their therapeutic effects to an ability to block
Publikováno v:
Psychological Medicine. 10:307-313
SYNOPSISThe dipeptidyl peptidase, angiotensin-converting enzyme (EC 3.4.15.1), was measured in various regions of post-mortem brains. Results from 51 patients with the hospital diagnosis of schizophrenia who were divided into the clinical categories
Autor:
A.V.P. Mackay
Publikováno v:
British Journal of Pharmacology. 51:509-520
1 An organ culture system is described for the in vitro maintenance of superior cervical sympathetic ganglia taken from mice of any age. The relation of tyrosine hydroxylase (T-OH) activity to ganglionic noradrenaline (NA) content has been investigat
Autor:
ElaineK. Perry, B.E. Tomlinson, A.J. Cross, R. Lofthouse, Frank Owen, A. Longden, Leslie L. Iversen, Joanna Barnes, RobertH. Perry, E.D. Bird, Michael Shepherd, T. J. Crow, Garry Blessed, E.G. Spokes, Raymond Levy, A.V.P. Mackay
Publikováno v:
The Lancet. 311:35-37
Autor:
A.V.P. Mackay, Leslie L. Iversen
Publikováno v:
Brain Research. 48:424-426
Autor:
P.N. Hamilton, A.V.P. Mackay
Publikováno v:
Brain research. 118(1)
A functional role for dopamine (DA) in the extrapyramidal system of the mammalian brain has been accepted for over a decade (for reviews see refs. 3 and 10). Until recently it seemed that the distribution of central dopaminergic neurones in mammals w
Publikováno v:
The New England journal of medicine. 300(9)
Publikováno v:
Life sciences. 23(5)
The neuroleptic ligand 3H-spiperone binds saturably to areas of human and rat brain which are rich in either dopamine (DA) or 5- hydroxytryptamine (5-HT). 2-Amino-6, 7-dihydroxytetralin (ADTN) and cinanserin were found to displace 3H-spiperone select