Zobrazeno 1 - 10
of 127
pro vyhledávání: '"A.T. Mcknight"'
Autor:
Kneen Clare O, Michael J. Gilbert, David F. Tattersall, A.T. McKnight, Mark Duchnowski, Colin T. Dourish, Nigel R. Newberry, Margaret S. Beer, Nikki Mudunkotuwa, Michael Rigby, Christopher John Swain, Janet J. Maguire
Publikováno v:
Drug Development Research. 25:17-28
The 5-HT3 receptor antagonist properties of the novel compound L-683,877 (−) (2′-(1-methyl-1H-indol-3-yl)-)spiro(1-azabicyclo[2.2.2]octane-3,5′(4′H)-oxazole) have been characterised in vitro and in vivo. In radioligand binding studies, L-683,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb8ca03a4ddc557358102b7652d086e3
https://doi.org/10.1002/ddr.430250103
https://doi.org/10.1002/ddr.430250103
Publikováno v:
Neuropharmacology. 33(6)
The effect of sulphated cholecystokinin octapeptide (CCK-8S) on immediate early gene expression in the rat CNS was investigated using the technique of in situ hybridization. A rapid and transient induction of c-fos, NGFI-A and NGFI-B (nerve growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71129dd3d190734ca2f94af99249da8b
https://pubmed.ncbi.nlm.nih.gov/7936109
https://pubmed.ncbi.nlm.nih.gov/7936109
Autor:
Kate Scholey, J.E. Semark, A.T. McKnight, Shil Patel, E.A. Harley, Nigel R. Newberry, Peter H. Hutson, Richard Hargreaves, Leslie J. Street, Stephen B. Freedman
Publikováno v:
British journal of pharmacology. 107(2)
1. L-689,660, 1-azabicyclo[2.2.2]octane, 3-(6-chloropyrazinyl)maleate, a novel cholinomimetic, demonstrated high affinity binding (pKD (apparent) 7.42) at rat cerebral cortex muscarinic receptors. L-689,660 had a low ratio (34) of pKD (apparent) valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cebc67010f03c69ad4398dfed0c1b4
https://pubmed.ncbi.nlm.nih.gov/1422595
https://pubmed.ncbi.nlm.nih.gov/1422595
Autor:
Janet J. Maguire, Leslie L. Iversen, Brian John Williams, Alan C. Foster, A.T. McKnight, A.E. Fletcher, Jenny Longmore, N.J. Elliott, R. Tridgett
Publikováno v:
British journal of pharmacology. 104(2)
1. The interaction at tachykinin receptors of a series of novel cyclic hexapeptides has been examined by use of radioligand binding assays (NK1 and NK3 sites in rat cortex, NK2 sites in hamster urinary bladder) and functional pharmacological assays (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb8c04cad75a70cd45d35c93a5a8906
https://pubmed.ncbi.nlm.nih.gov/1665732
https://pubmed.ncbi.nlm.nih.gov/1665732
Autor:
Leslie L. Iversen, Nigel R. Newberry, Janet J. Maguire, R. Baker, A.T. McKnight, Michael J. Gilbert, N.T. Mudunkotuwa, Shil Patel, Leslie J. Street, Stephen B. Freedman, J.K. Tang, Angus Murray Macleod, E.A. Harley, John Saunders
Publikováno v:
Scopus-Elsevier
1 A novel series of non-quaternary oxadiazole-based muscarinic agonists demonstrated high affinity for muscarinic receptors. 2. These agonists possessed high efficacy in the nanomolar range at muscarinic receptors in the superior cervical ganglion, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4578b6d195a713546d7503725df9c4ac
https://europepmc.org/articles/PMC1917727/
https://europepmc.org/articles/PMC1917727/
Autor:
P. Hitchcott, A.T. McKnight
Publikováno v:
Trends in Neurosciences. 17:44-45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1301918061d42eae8eb43ee2cef906d0
https://doi.org/10.1016/0166-2236(94)90037-x
https://doi.org/10.1016/0166-2236(94)90037-x
Autor:
Leslie L. Iversen, Raymond Baker, A.T. McKnight, John Saunders, Kate Scholey, Richard Hargreaves, Nigel R. Newberry, Stephen B. Freedman, Graham Andrew Showell, Shil Patel, E.A. Harley
Publikováno v:
European Journal of Pharmacology. 215:135-136
The oxadiazole L-687,306 is a high affinity muscarinic agonist with a N-methylscopolamine/ oxotremorine-M binding profile predictive of a partial agonist. L-687,306 showed marked selectivity in functional pharmacological assays. L-687,306 was a parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb7470eab110a7ea0c4dd8f1af2fac2
https://doi.org/10.1016/0014-2999(92)90618-e
https://doi.org/10.1016/0014-2999(92)90618-e
Publikováno v:
Journal of Neurochemistry. 45:1034-1042
Following incubation of [3H]dynorphin A (1-8) and [3H]dynorphin A (1-9) with suspensions of guinea pig brain membranes, analysis of the supernatants by HPLC has shown that both peptides are degraded at 25 degrees C and at 0 degrees C. Bestatin and ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad81a6239cec15da96b2efc8f84cebf
https://doi.org/10.1111/j.1471-4159.1985.tb05520.x
https://doi.org/10.1111/j.1471-4159.1985.tb05520.x
Publikováno v:
Proceedings of the Royal Society of London. Series B. Biological Sciences. 213:171-182
The effects of electrical field stimulation on the contents of[Met]enkephalin and [Leu]enkephalin were determined in myenteric plexus-longitudinal muscle preparations of the guinea-pig small intestine. Cycloheximide (0.1 mM) was present in all experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3b38d1985ba13da270421f900f11f7
https://doi.org/10.1098/rspb.1981.0060
https://doi.org/10.1098/rspb.1981.0060