Zobrazeno 1 - 10
of 76
pro vyhledávání: '"A.S. Tyms"'
Autor:
C.G. Bridges, S.P. Ahmed, Robert J. Nash, A.S. Tyms, Elaine A. Porter, D.L. Taylor, Mohinder S. Kang
Publikováno v:
Biochemical and Biophysical Research Communications. 208:267-273
The 6-O-butanoyl derivative of castanospermine (MDL 28,574: BUCAST), an inhibitor of glycoprotein processing, blocked the growth of herpes simplex virus type-2 with the effect markedly enhanced by exposure of cells to the compound pre- as well as pos
Autor:
Philip L. Smith, Alan D. Cardin, L. Hyde, A.S. Tyms, D L Taylor, Dale T. Blankenship, K. Schroeder, Terry L. Bowlin, K A Stauderman
Publikováno v:
Journal of Biological Chemistry. 266:13355-13363
The stilbene disulfonic acids 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid and, 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid bound the variable-1 immunoglobulin-lik
Publikováno v:
AIDS. 5:693-698
The antiviral activity of 6-0-butanoylcastanospermine (MDL 28,574) [50% inhibitory concentration (IC50: 1.1 microM)] in JM cells infected with a recent isolate of HIV-1 (GB8), was compared with other inhibitors of glycoprotein-processing enzymes. N-b
Autor:
M. J. Mullins, A.S. Tyms, T M Brennan, R. L. Jackson, C G Bridges, Alan D. Cardin, D.L. Taylor
Publikováno v:
Antiviral research. 28(2)
MDL 101028, a novel biphenyl disulphonic acid urea co-polymer was designed and synthesised as a heparin mimetic. This low molecular weight polymer showed potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication in a number of host
Publikováno v:
Antiviral research. 26(2)
MKC-442, a derivative of the non-nucleoside reverse transcriptase (RT) inhibitor 1-[(2-hydroxyethoxy)methyl)-6-(phenylthio)thymidine (HEPT), showed potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro, u
Publikováno v:
Cellular immunology. 159(1)
We recently demonstrated that 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) prevented the infection of T cells by human immunodeficiency virus type-I (Cardin et al., J, Biol. Chem . 266, 13355, 1991). In the present study we have used a p
Autor:
D.L. Taylor, D.T. Blankenship, K. Schroeder, Alan D. Cardin, A.S. Tyms, Philip L. Smith, L. Hyde, Terry L. Bowlin
Publikováno v:
Antiviral Research. 15:125
Publikováno v:
Virology. 168:67-72
Lytic infection with herpes virus type 1 (HSV-1) causes the accumulation of a 40-kDa cellular protein (p40) which is also overexpressed in cultured cells transformed by HSV or other agents and in human cervical tumors. Accumulation of p40 is dependen
Publikováno v:
Biochemical and Biophysical Research Communications. 86:312-318
Both methyglyoxal bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase (EC.4.1.1.50) and DL-α-methylornithine, an inhibitor of ornithine decarboxylase (EC.4.1.1.17), are shown to be potent inhibitors of the replication of huma
Autor:
Thomas W. Rademacher, Abraham Karpas, P.W. Smith, George W. J. Fleet, Linda E. Fellows, Sigthor Petursson, Sung K. Namgoong, Nigel Ramsden, Raymond A. Dwek, Witty David R, Jong Chan Son, Francis Xavier Wilson, A.S. Tyms, Gary S. Jacob
Publikováno v:
FEBS Letters. (1-2):128-132
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 10