Zobrazeno 1 - 10
of 58
pro vyhledávání: '"A.R. Disanto"'
Autor:
A.R. Disanto, Thomas J. Hochadel, Richard J. Morales, Jeffrey S. Barrett, John Darnow, Shashank Rohatagi, Albert J. Azzaro, Sara K. Watson, Kimberly E. DeWitt
Publikováno v:
The Journal of Clinical Pharmacology. 37:238-247
Orally administered selegiline hydrochloride is a selective monoamine oxidase type B inhibitor at the recommended regimen of 10 mg/day, but it loses selectivity at higher doses. In bypassing first-pass metabolism, a 24-hour application of transdermal
Autor:
Richard J. Morales, Matthew J. Palazzolo, Peter J. Thomford, A.R. Disanto, Jeffrey S. Barrett, Eric M. Larsen
Publikováno v:
Biopharmaceutics & Drug Disposition. 18:165-184
The toxicology and toxicokinetics of a selegiline transdermal system (STS) were evaluated in a 3 month dog study of daily 24h applications of placebo 4, 8, or 12 STSs in 32 male and 32 female beagle dogs. Each STS delivered approximately 5 mg selegil
Autor:
A.R. Disanto
Publikováno v:
Journal of the American Pharmaceutical Association (1961). 16:365-368
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1713-1716
Plasma level data on two investigational capsule formulations of propoxyphene with similar physicochemical parameters demonstrate that the formulations have different in vivo bioavailabilities. The potential for bioavailability problems with water-so
Publikováno v:
The Journal of Clinical Pharmacology. 17:324-333
Intramuscularly administered methylprednisolone sodium phosphate (Medrol Stabisol) in single doses of 40, 80, or 160 mg (methylprednisolone equivalents) had a similar effect as the same doses of methylprednisolone sodium succinate (Solu-Medrol) with
Publikováno v:
The Journal of Clinical Pharmacology. 20:428-436
The pharmacokinetic and biopharmaceutic profiles of a single dose of oral cortisone acetate were developed for 23 healthy normal adult volunteers using cortisone and cortisol plasma concentration data. Cortisone acetate was rapidly absorbed and conve
Publikováno v:
Journal of Pharmaceutical Sciences. 68:586-588
Oral coadministration of a single 250-mg tetracycline capsule and 60 ml of a bismuth subsalicylate antidiarrheal mixture reduced tetracycline absorption by 34% without appearing to perturb its absorption or disposition rate. A pronounced increase in
Publikováno v:
Journal of clinical pharmacology. 19(11-12)
Since it has been reported by several authors that colestipol HCl and clofibrate have an additive effect in lowering serum cholesterol levels, it was felt advisable to evaluate the blood levels of clofibrate when given simultaneously with colestipol
Publikováno v:
Journal of pharmaceutical sciences. 67(11)
The effect of a kaolin--pectin antidiarrheal suspension on the bioavailability of orally administered clindamycin was evaluated by model-dependent pharmacokinetic techniques. Each subject's serum clindamycin concentration--time data in the absence of
Autor:
K.A. Desante, A.R. Disanto
Publikováno v:
Journal of pharmaceutical sciences. 64(1)
In a clinical study involving 22 normal adult volunteers, the bioavailability and pharmacokinetics of prednisone tablets with varying dissolution rates were evaluated. Serum levels were measured by a radioimmunoassay for prednisolone. Absorption rate