Výsledky vyhledávání - "A.P Griffiths"

A study of mitochondrial DNA D-loop mutations and p53 status in nonmelanoma skin cancer

Autor: Paul D. Lewis, Sarah L. Prior, A.P. Griffiths

Publikováno v: British Journal of Dermatology. 161:1067-1071

Summary Background Mitochondrial DNA (mtDNA) displacement-loop (D-loop) mutations have previously demonstrated potential as smoking-induced biomarkers in oral squamous cell carcinoma (SCC). Additionally, they have been observed in SCC and basal cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b391376419494885ba32edb35a168d
https://doi.org/10.1111/j.1365-2133.2009.09304.x

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Immunohistochemical study of nuclear factor- B activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers

Autor: T H Brown, James M. Manson, Gareth J.S. Jenkins, Jane Mikhail, S Caplin, N Toffazal, R Bowden, A.P. Griffiths, J. M. Parry, A. Alhamdani, John Baxter

Publikováno v: Journal of Clinical Pathology. 60:1232-1237

To determine if immunohistochemistry (IHC) could be used to monitor nuclear factor-kappaB (NF-kappaB) activity in oesophageal adenocarcinoma and pre-malignant (Barrett's) oesophageal tissues, relative to normal oesophageal mucosa. The pro-inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8729a36feed668c7e6fa857de75a467f
https://doi.org/10.1136/jcp.2006.043976

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The bile acid deoxycholic acid (DCA) at neutral pH activates NF- B and induces IL-8 expression in oesophageal cells in vitro

Autor: John Baxter, James M. Parry, Gareth J.S. Jenkins, Anja Wilmes, A.P. Griffiths, Shareen H. Doak, K. Harries

Publikováno v: Vrije Universiteit Amsterdam

Barrett's oesophagus patients accumulate chromosomal defects during the histological progression to cancer, one of the most prominent of which is the amplification of the whole of chromosome 4. We aimed to study the role that the transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859d780002e45cbe08834461b19937bb
https://doi.org/10.1093/carcin/bgh032

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Reflux composition influences the level of NF-κB activation and upstream kinase preference in oesophageal adenocarcinoma cells

Autor: A.P. Griffiths, Elizabeth McAdam, S. Spencer-Harty, John Baxter, Hasan Haboubi, C. Davies, Gareth J.S. Jenkins

Publikováno v: International Journal of Cancer.

Oesophageal adenocarcinoma (OA) incidence is rising and prognosis is poor. Understanding the molecular basis of this malignancy is key to finding new prevention and treatment strategies. Gastroesophageal reflux disease is the primary cause of OA, usu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6ac26667f3bd3102cffc8cce041f1b7
https://doi.org/10.1002/ijc.29029

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Inducible Nitric Oxide Synthase (iNOS) and Nitric Oxide (NO) are Important Mediators of Reflux-induced Cell Signalling in Esophageal Cells

Autor: A.P. Griffiths, Elizabeth McAdam, Christine Davies, George Forrester, Sam Spencer-Harty, Gareth J.S. Jenkins, Zak Eltahir, Hasan Haboubi, John Baxter

Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) has been implicated in both DNA damage induction and aberrant cell signalling in various tissue and cell backgrounds. We investigated here the role of iNOS and NO in DNA damage indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3820b53dda5277dfdd6deaff954b2adb
https://cronfa.swan.ac.uk/Record/cronfa12373

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Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin

Autor: A. Beddall, A.P. Griffiths, S. Pegler

Publikováno v: The journal of the Royal Society for the Promotion of Health. 128(6)

We report a case of fatal internal haemorrhage in an elderly man who consumed only cranberry juice for two weeks while maintaining his usual dosage of warfarin. We propose that naturally occurring compounds such as flavonoids, which are present in fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe431aabebd76328b3be266103babe29
https://pubmed.ncbi.nlm.nih.gov/19058474

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Mitochondrial DNA mutations in oral squamous cell carcinoma

Autor: P.W. Baxter, A.P. Griffiths, Sarah L. Prior, Paul D. Lewis, J.M. Baxter, S.C. Hodder, K.C. Silvester

It has previously been demonstrated that mitochondrial DNA (mtDNA) mutations within the ND2 gene of histologically normal parotid salivary gland tissue of smokers may be molecular biomarkers for smoking-induced mtDNA damage. Oral squamous cell carcin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9a346f6d190b01d2a23dc779b1709b
https://cronfa.swan.ac.uk/Record/cronfa1392

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Ileitis due to Yersinia pseudotuberculosis in Crohn's disease

Autor: R Homewood, P.D Duane, A.P Griffiths, A Lewis, C.P Gibbons, D Richards

Publikováno v: The Journal of infection. 47(4)

We present the case of a young woman with fulminating terminal ileitis due to Yersinia pseudotuberculosis, in whom Crohn's disease was subsequently diagnosed. Serological testing was prompted by radiological, macroscopic and histological changes whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30388cc74b10dc71be70f2e8cba83d5f
https://pubmed.ncbi.nlm.nih.gov/14556758

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