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pro vyhledávání: '"A.M. de Vos"'
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Autor:
Kurt Deshayes, Mark Ultsch, Felix Vajdos, Nicholas J. Skelton, Jun Liu, A.M. de Vos, M.L. Schaffer
Publikováno v:
Biochemistry. 40:11022-11029
Despite efforts spanning considerably more than a decade, a high-resolution view of the family of proteins known as insulin-like growth factors (IGFs) has remained elusive. IGF-1 consists of three helical segments which are connected by a 12-residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb17bf413298fbb768797ad2ef69ce9
https://doi.org/10.1021/bi0109111
https://doi.org/10.1021/bi0109111
Autor:
Christian Wiesmann, A.M. de Vos
Publikováno v:
Cellular and Molecular Life Sciences. 58:748-759
Neurotrophins are critical for the development and maintenance of the peripheral and central nervous system. These highly homologous, homodimeric growth factors control cell survival, differentiation, growth cessation, and apoptosis of sensory neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db653ad6db42213d64376baf9e957720
https://doi.org/10.1007/pl00000898
https://doi.org/10.1007/pl00000898
Autor:
Arieh Gertler, H.W. Christinger, P.A. Elkins, Anthony A. Kossiakoff, E. Sakal, Y. Sandowski, A.M. de Vos
Publikováno v:
Nature Structural Biology. 7:808-815
Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::794bb80cceaebc08483ec5a21969de5f
https://doi.org/10.1038/79047
https://doi.org/10.1038/79047
Autor:
Germaine Fuh, Christian Wiesmann, H.W. Christinger, Yongmei Chen, Henry B. Lowman, A.M. de Vos, P. Mckay, Bing Li
Publikováno v:
Journal of Molecular Biology. 293:865-881
The Fab portion of a humanized antibody (Fab-12; IgG form known as rhuMAb VEGF) to vascular endothelial growth factor (VEGF) has been affinity-matured through complementarity-determining region (CDR) mutation, followed by affinity selection using mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2556b5b0e599a216794a12eccaf516
https://doi.org/10.1006/jmbi.1999.3192
https://doi.org/10.1006/jmbi.1999.3192
Autor:
Sarah G. Hymowitz, H.W. Christinger, Mark P. O'Connell, A.M. de Vos, Germaine Fuh, Robert F. Kelley, M.H. Ultsch, Avi Ashkenazi
Publikováno v:
Molecular Cell. 4(4):563-571
Formation of a complex between Apo2L (also called TRAIL) and its signaling receptors, DR4 and DR5, triggers apoptosis by inducing the oligomerization of intracellular death domains. We report the crystal structure of the complex between Apo2L and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6536c8e47ef95d595401f8bf0d0438f7
Publikováno v:
Nature. 401:184-188
Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons1. These events are mediated by NGF as a result of binding to its two cell-surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9c8eb42cdecd5ba322a0a15b5e31ca
https://doi.org/10.1038/43705
https://doi.org/10.1038/43705
Autor:
M. Yang, J. Henrich, S.H. Bass, M.H. Ultsch, A.M. de Vos, Dorothea Reilly, L.C. Simmons, Christian Wiesmann
Publikováno v:
Journal of Molecular Biology. 290:149-159
The Trk receptors and their neurotrophin ligands control development and maintenance of the nervous system. The crystal structures of the ligand binding domain of TrkA, TrkB, and TrkC were solved and refined to high resolution. The domains adopt an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528fa9fc6251109f2b27229398af6c42
https://doi.org/10.1006/jmbi.1999.2816
https://doi.org/10.1006/jmbi.1999.2816
Autor:
Brian C. Cunningham, C.J. Keenan, Wayne J. Fairbrother, Andrea G. Cochran, Christian Wiesmann, H.W. Christinger, A.M. de Vos, Gloria Meng
Publikováno v:
Biochemistry. 37:17765-17772
Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and, therefore, a prime therapeutic target for the development of antagonists for the treatment of cancer. As a first step toward this goal, phage display was used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14094e1ac778aff59c3bc1e4f99bd19f
https://doi.org/10.1021/bi9819327
https://doi.org/10.1021/bi9819327
Publikováno v:
European Heart Journal, 34, 636-636
Purpose: Operator volume is a determinant of quality of medical procedures. In the Netherlands minimum volumes are being introduced for certain cardiac procedures. The purpose of this study is to establish procedure volumes in current cardiac practic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a1a25d4ce18149e4e656425a1bf7bd
https://hdl.handle.net/1887/101126
https://hdl.handle.net/1887/101126
