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Akademický článek
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Publikováno v:
Cell Mol Life Sci
DNA polymerases are vital for the synthesis of new DNA strands. Since the discovery of DNA polymerase I in Escherichia coli, a diverse library of mammalian DNA polymerases involved in DNA replication, DNA repair, antibody generation, and cell checkpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130b0aa2381ed29fbbac3ee84e96db83
https://doi.org/10.1007/s00018-019-03368-y
https://doi.org/10.1007/s00018-019-03368-y
Single-molecule total internal reflection fluorescence (TIRF) microscopy allows for real-time visualization of macromolecular dynamics and complex assembly. Prism-based TIRF microscopes (prismTIRF) are relatively simple to operate and can be easily m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::702dae5dfa8caeae8a530db0877bfa45
https://doi.org/10.1101/2021.05.10.443430
https://doi.org/10.1101/2021.05.10.443430
Autor:
N.M. Hoitsma, Sunbok Jang, Bennett Van Houten, Bret D. Freudenthal, Emily C. Beckwitt, A.M. Whitaker, Pratul K Agarwal
Publikováno v:
Nucleic Acids Research
Base excision repair (BER) maintains genomic stability through the repair of DNA damage. Within BER, AP-endonuclease 1 (APE1) is a multifunctional enzyme that processes DNA intermediates through its backbone cleavage activity. To accomplish these rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3675d618a1db8fa653b310c515140641
https://doi.org/10.1093/nar/gkaa496
https://doi.org/10.1093/nar/gkaa496
Publikováno v:
DNA Repair (Amst)
Under conditions of oxidative stress, reactive oxygen species (ROS) continuously assault the structure of DNA resulting in oxidation and fragmentation of the nucleobases. When the nucleobase structure is altered, its base-pairing properties may also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c51e19f32d4b4f1bbc014bd8446d162
https://europepmc.org/articles/PMC7295089/
https://europepmc.org/articles/PMC7295089/
Autor:
Jennifer L. Illuzzi, Bret D. Freudenthal, A.M. Whitaker, Peter J. McKinnon, Daniel R. McNeill, Wesley J. Stark, David M. Wilson
Publikováno v:
Mutagenesis
DNA is susceptible to a range of chemical modifications, with one of the most frequent lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (e.g. alkylation) or spontaneous hydrolysis of the N-glycosidic bond that link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e0fc1d941281f3e445296b98c06b02
https://europepmc.org/articles/PMC7016205/
https://europepmc.org/articles/PMC7016205/
Publikováno v:
Acta Crystallographica Section D Structural Biology. 74:760-768
Despite the DNA duplex being central to biological functions, many intricacies of this molecule, including the dynamic nature of mismatched base pairing, are still unknown. The unique conformations adopted by DNA mismatches can provide insight into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531cfcfca8ebc1292ea747c8989c2249
https://doi.org/10.1107/s2059798318003340
https://doi.org/10.1107/s2059798318003340
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is an essential DNA repair enzyme which uses a single active site to process DNA damage via two distinct activities: (1) AP-endonuclease and (2) 3′ to 5′ exonuclease. The AP-endonuclease acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2fe77881f59b559cc1cdf26e708de8f
https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381
https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381
Akademický článek
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Akademický článek
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