Výsledky vyhledávání - "A.M. Hutcheson"

Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract

Autor: Alan R. Prescott, A.M. Hutcheson, Jer R. Kuszak, Shigeo Masaki, Alfred Wegener, Aileen Sandilands, Rebecca K. Zoltoski, Roy A. Quinlan

Publikováno v: Experimental Eye Research. 76:385-391

In this report, the phenotype associated with the first targeted knockout of the lens specific intermediate filament gene CP49 is described. Several surprising observations have been made. The first was that no cataract was observed despite the fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623f7d5c2517dd1a2c8fa7e55a6ae60b
https://doi.org/10.1016/s0014-4835(02)00330-5

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Altered aggregation properties of mutant γ-crystallins cause inherited cataract

Autor: Cait E. MacPhee, Alan R. Prescott, Gijs F.J.M. Vrensen, Aileen Sandilands, Christopher M. Dobson, Shigeo Masaki, Raimund B. Lutz, Heather A. Long, A.M. Hutcheson, N Klopp, Jana Löster, Jochen Graw, Roy A. Quinlan

Publikováno v: EMBO J. 21, 6005-6014 (2002)

Protein inclusions are associated with a diverse group of human diseases ranging from localized neurological disorders through to systemic non-neuropathic diseases. Here, we present evidence that the formation of intranuclear inclusions is a key even

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6149081c1c97ddad7ad0ae45c6bb0251
https://doi.org/10.1093/emboj/cdf609

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Up-regulation of novel intermediate filament proteins in primary fiber cells: An indicator of all vertebrate lens fiber differentiation?

Autor: Harry Maisel, Michael Kasper, Ailian Liu, Paul S. Wallace, Mark E. Ireland, Michael S. Poosch, Roy A. Quinlan, Jochen Graw, Alan R. Prescott, Aileen Sandilands, Dennis J. Goebel, A.M. Hutcheson

Publikováno v: The Anatomical Record. 258:25-33

The early embryonic development and expression patterns of the eye lens specific cytoskeletal proteins, CP49 and CP95, were determined for the chick and were found to be similar in both human and mouse. These proteins, as well as their homologs in ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45e351f1b6daf14e040f6c5cf0829946
https://doi.org/10.1002/(sici)1097-0185(20000101)258:1<25::aid-ar3>3.0.co

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The Cardiomyopathy and Lens Cataract Mutation in αB-crystallin Alters Its Protein Structure, Chaperone Activity, and Interaction with Intermediate Filaments in Vitro

Autor: Paul J. Muchowski, Roy A. Quinlan, A.M. Hutcheson, Ming Der Perng, Paul R.L.A. van den IJssel, Gabrielle J.S. Wu, John I. Clark

Publikováno v: Journal of biological chemistry, 1999, Vol.274(47), pp.33235-33243 [Peer Reviewed Journal]

Desmin-related myopathy and cataract are both caused by the R120G mutation in alphaB-crystallin. Desmin-related myopathy is one of several diseases characterized by the coaggregation of intermediate filaments with alphaB-crystallin, and it identifies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce040ea4391ac5b60008f8ead8ada213
https://doi.org/10.1074/jbc.274.47.33235

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Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation

Autor: A.M. Hutcheson, J. Richards, Aileen Sandilands, Paul G. FitzGerald, Alan R. Prescott, Roy A. Quinlan, J.M. Carter

Publikováno v: Journal of Cell Science. 108:1397-1406

The cells of the eye lens contain the type III intermediate filament protein vimentin, as well as two other intermediate filament proteins, CP49 and filensin. These two proteins appear to be unique to the differentiated lens fibre cell. Immunoblottin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a73336fd1b3e538256340db2e605a11
https://doi.org/10.1242/jcs.108.4.1397

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In vitro studies on the assembly properties of the lens proteins CP49, CP115: Coassembly with α-crystallin but not with vimentin

Autor: J.M. Carter, A.M. Hutcheson, Roy A. Quinlan

Publikováno v: Experimental Eye Research. 60:181-192

A rapid one-step purification procedure for CP49, an intermediate filament protein found in the lens, is described using reverse-phase HPLC. This protein is one of the major intermediate filament proteins of the lens fibre cells and is found in both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfe1c7bf4639fb0607c832573590e00
https://doi.org/10.1016/s0014-4835(95)80009-3

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The 53kDa polypeptide component of the bovine fibre cell cytoskeleton is derived from the 115kDa beaded filament protein: evidence for a fibre cell specific intermediate filament protein

Autor: Jane M. Carter, A.M. Hutcheson, Roy A. Quinlan, David G. Campbell

Publikováno v: Current Eye Research. 11:909-921

The 115kDa protein found enriched in the PMCC (plasma membrane-cytoskeleton complex) fraction of the cortex in bovine lens fibre cells is proteolytically processed to a stable 53kDa product. The 115 kDa protein and the 53kDa polypeptide have been pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa66618c99d3af283b5a102b15cbf72a
https://doi.org/10.3109/02713689209033488

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Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton

Autor: Xiahou Gong, John James, Milos Pekny, Roy A. Quinlan, A.M. Hutcheson, Xin Wang, Alfred Wegener, Aileen Sandilands, Alan R. Prescott

Publikováno v: Experimental eye research. 78(1)

Here we report the first natural mutation in the mouse Bfsp2 gene. Characterisation of mouse Bfsp2 in the 129X1/SvJ revealed a mutation that deleted the acceptor site of exon 2. This results in exon 1 being erroneously spliced to exon 3 causing a fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b6b4eabac71d37fb418d71e4c8dbac
https://pubmed.ncbi.nlm.nih.gov/15037121

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The eye lens cytoskeleton

Autor: Alan R. Prescott, Ralf Dahm, A.M. Hutcheson, Christopher Gribbon, J.M. Carter, J E Procter, Paul S. Wallace, Aileen Sandilands, Roy A. Quinlan

Publikováno v: Eye (London, England). 13

During lens cell differentiation there are a number of very characteristic morphological changes that occur. These include a 50- to 100-fold increase in cell length as the equatorial lens epithelial cells differentiate into fibre cells and the loss o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ac919c97dc546dec0819cecfb516fb
https://pubmed.ncbi.nlm.nih.gov/10627818

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