Zobrazeno 1 - 10
of 18
pro vyhledávání: '"A.M. Hissink"'
Publikováno v:
Chemico-Biological Interactions 103 (1997)
Chemico-Biological Interactions, 103, 17-33
Chemico-Biological Interactions, 103, 17-33
The biotransformation and kinetics of 1,4-dichlorobenzene (1,4-DCB) were studied in male Wistar rats at three oral dose levels (10, 50 and 250 mg/kg). The effect of induction of CYP2E1 by isoniazid on the kinetics and biotransformation was determined
Autor:
J. De Jongh, J.M. Frazier, Michael Gülden, Christoph A. Reinhardt, Bas J. Blaauboer, G.L. Kedderis, André Guillouzo, K. Groen, J. B. Houston, G. Johanson, A.M. Hissink, C.T.A. Evelo, M.K. Bayliss, J.J.M. van de Sandt, G. Semino, José V. Castell
Publikováno v:
Alternatives to Laboratory Animals. 24:473-497
Publikováno v:
Xenobiotica, 1, 26, 89-105
Toxicity of halobenzenes has been ascribed mainly to their epoxides, but recent studies with bromobenzene have shown that secondary quinone metabolites are also involved in the alkylation of hepatic proteins. However, the relative contribution of the
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 232:199-207
In this study we investigated the role of indole-3-acetonitrile, indole-3-carbinol, indole and tryptophan in the formation of N -nitroso compounds in green cabbage extracts. Green cabbage extracts were separated by gel permeation chromatography. Frac
Publikováno v:
Toxicology and Applied Pharmacology 145 (1997)
Toxicology and Applied Pharmacology, 145, 109-109
Toxicology and Applied Pharmacology, 145, 109-109
Our goal was to characterize possible species and strain differences in the hepatic microsomal biotransformation of 1,4-dichlorobenzene (1,4-DCB). Experiments compared extent of labeled 1,4-DCB conversion to oxidized metabolites, glutathione conjugat
Publikováno v:
Toxicology and Applied Pharmacology, 145, 301-310
Toxicology and Applied Pharmacology 145 (1997)
Toxicology and Applied Pharmacology 145 (1997)
A physiologically based pharmacokinetic (PB-PK) model was developed for 1,2-dichlorobenzene (1,2-DCB) for the rat. This model was adjusted for the human situation, using human in vitro parameters, including a Vmax and Km determined with human microso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c81e771c9f5a7f50fc42cf8c4dfbc5
https://research.wur.nl/en/publications/a-physiologically-based-pharmacokinetic-pb-pk-model-for-12-dichlo
https://research.wur.nl/en/publications/a-physiologically-based-pharmacokinetic-pb-pk-model-for-12-dichlo
Publikováno v:
Chemical Research in Toxicology, 8, 9, 1249-1256
The oxidative biotransformation of 1, 2-dichlorobenzene (1, 2-DCB) was investigated using hepatic microsomes from male Wistar, Fischer-344 and Sprague-Dawley (SD) rats, phenobarbital (PB)- and isoniazid (ISO) pretreated male Wistar rats and from man.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d77e61f58dd44e4dc0423f7a97834c2
http://resolver.tudelft.nl/uuid:8188ec52-3acb-464e-99e2-73ad6ea807d8
http://resolver.tudelft.nl/uuid:8188ec52-3acb-464e-99e2-73ad6ea807d8
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