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Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation

Autor: Joachim Jaeger, Pia A. Thommes, Andrew J. Baron, A.L. Cherry, Caitriona A. Dennis, Leslie E. Eisele

Publikováno v: Print: 0022-538X

The RNA-dependent RNA polymerase (RdRp) of hepatitis C virus (HCV) is essential for viral genome replication. Crystal structures of the HCV RdRp reveal two C-terminal features, a β-loop and a C-terminal arm, suitably located for involvement in posit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9cf10cd4306b9467432c72ccee2931
https://doi.org/10.1128/jvi.01106-14

Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3

Autor: Thomas Schwend, Magnus Monné, David Flot, Tsukasa Matsuda, Hiroki Okumura, A.L. Cherry, Luca Jovine, Ling Han

Publikováno v: Cell. 143(3):404-415

SummaryZP3, a major component of the zona pellucida (ZP) matrix coating mammalian eggs, is essential for fertilization by acting as sperm receptor. By retaining a propeptide that contains a polymerization-blocking external hydrophobic patch (EHP), we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d20b1a4e4cd614cdcaa14b610eae7b3

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation

Autor: Luca Jovine, Thomas Schwend, C. Finta, A.L. Cherry, Juan Astorga-Wells, M. Karlstrom, Daniele de Sanctis, M. Del Campo, Qianren Jin, R. Toftgard, Angela Criswell, Roman A. Zubarev

Publikováno v: Acta Crystallographica Section D: Biological Crystallography
Acta Crystallographica Section D: Biological Crystallography, International Union of Crystallography, 2013, 69, pp.2563-2579. ⟨10.1107/S0907444913028473⟩
'Acta Crystallographica D ', vol: 69, pages: 2563-2579 (2013)
Print: 0907-4449

Crystal and small-angle X-ray scattering structures of full-length human SUFU alone and in complex with the conserved SYGHL motif from GLI transcription factors show major conformational changes associated with binding and reveal an intrinsically dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2603de7a293a40df692c132f9b3f7e90
https://hal.archives-ouvertes.fr/hal-01572877/file/Acta_Crystallographica_D_Vol_69_pp_2563.pdf

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response

Autor: Cheng Peng, Peter J. McKinnon, Junjie Chen, G. Taucher-Scholz, Martin F. Lavin, Markus Fusser, Sachin Katyal, Olivier J. Becherel, Bernd Epe, Burkhard Jakob, Nuri Gueven, Amanda W. Kijas, Stephen J. Smerdon, A.L. Cherry

Publikováno v: Nucleic Acids Research
Print: 0305-1048

Aprataxin, defective in the neurodegenerative disorder ataxia oculomotor apraxia type 1, resolves abortive DNA ligation intermediates during DNA repair. Here, we demonstrate that aprataxin localizes at sites of DNA damage induced by high LET radiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e7b5e7773664f333e876d3e2a8ed3e
https://pubmed.ncbi.nlm.nih.gov/20008512