Výsledky vyhledávání - "A.J. van Rozen"

GHS-R1a signaling in the DMH and VMH contributes to food anticipatory activity

Autor: Roger A.H. Adan, M A van Gestel, Keith M. Garner, Mieneke C. M. Luijendijk, Rahul Pandit, Maike A.D. Brans, E M van der Zwaal, Arjen J. Boender, A.J. van Rozen, Myrte Merkestein, Judith Hendriks

Publikováno v: International Journal of Obesity. 38:610-618

Rats that have restricted access to food at a fixed time point of the circadian phase display high levels of food anticipatory activity (FAA). The orexigenic hormone ghrelin has been implicated in the regulation of FAA. However, it is not known via w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8147d191ae92471130414917133f79
https://doi.org/10.1038/ijo.2013.131

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Neuropeptide Y and leptin sensitivity is dependent on diet composition

Autor: J.K. van den Heuvel, A.J. van Rozen, Leslie Eggels, Roger A.H. Adan, Mieneke C. M. Luijendijk, Ellen A. Fliers, Andries Kalsbeek, S E la Fleur

Publikováno v: Journal of neuroendocrinology, 26(6), 377-385. Wiley-Blackwell
Journal of Neuroendocrinology, 26(6), 377-85. Wiley-Blackwell

Rats on different free-choice (fc) diets for 1 week of either chow, saturated fat and liquid sugar (fcHFHS), chow and saturated fat (fcHF), or chow and liquid sugar (fcHS) have differential levels of neuropeptide Y (NPY) mRNA in the arcuate nucleus.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a59b3796e4d32131db478cb92a92d3
https://pure.amc.nl/en/publications/neuropeptide-y-and-leptin-sensitivity-is-dependent-on-diet-composition(376af6c4-037c-4d4f-974c-cb5f9c02b797).html

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A free-choice high-fat high-sugar diet induces glucose intolerance and insulin unresponsiveness to a glucose load not explained by obesity

Autor: Roger A.H. Adan, S E la Fleur, Andries Kalsbeek, Mieneke C. M. Luijendijk, A.J. van Rozen

Publikováno v: International journal of obesity (2005), 35(4), 595-604. Nature Publishing Group
International Journal of Obesity, 35, 595-604. Nature Publishing Group

Objectives: In diet-induced obesity, it is not clear whether impaired glucose metabolism is caused directly by the diet, or indirectly via obesity. This study examined the effects of different free-choice, high-caloric, obesity-inducing diets on gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ec94f0869b905d43eb4150210dbaa5
https://pure.amc.nl/en/publications/a-freechoice-highfat-highsugar-diet-induces-glucose-intolerance-and-insulin-unresponsiveness-to-a-glucose-load-not-explained-by-obesity(420476c9-b537-479b-84ea-a133ab570829).html

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A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia

Autor: S.E. La Fleur, Roger A.H. Adan, F Groeneweg, Mieneke C. M. Luijendijk, A.J. van Rozen

Publikováno v: International journal of obesity (2005), 34(3), 537-546. Nature Publishing Group

The mechanisms for how saturated fat and sugar-based beverages contribute to human obesity are poorly understood. This paper describes a series of experiments developed to examine the response of hypothalamic neuropeptides to diets rich in sugar and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665e2eac871fd2179b9bd8ea8fea2c9d
https://pure.amc.nl/en/publications/a-freechoice-highfat-highsugar-diet-induces-changes-in-arcuate-neuropeptide-expression-that-support-hyperphagia(58196b71-1f44-48a8-ab23-5568c4d1d86c).html

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Mutation of Serine 41 in the Neuron-Specific Protein B-50 (GAP-43) Prohibits Phosphorylation by Protein Kinase C

Autor: M. Kasperaitis, H. B. Nielander, Peter Schotman, W.H. Gispen, L.H. Schrama, A.B. Oestreicher, A.J. van Rozen

Publikováno v: Journal of Neurochemistry. 55:1442-1445

The neuron-specific, calmodulin-binding protein B-50 (also known as GAP-43, F1, or neuromodulin) is an endogenous substrate of protein kinase C (PKC). PKC exclusively phosphorylates Ser residues in B-50. As potential phosphorylation sites for PKC, Se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abf449252e054d2a839aacba6dded40
https://doi.org/10.1111/j.1471-4159.1990.tb03159.x

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Expression levels of B-50/GAP-43 in PC12 cells are decisive for the complexity of their neurites and growth cones

Autor: Peter Schotman, A.B. Oestreicher, W.H. Gispen, A.J. van Rozen, E.R.A. Jap Tjoen San, H. B. Nielander

Publikováno v: Journal of molecular neuroscience, 6, 185. Humana Press

To study the role of the protein B-50/GAP-43 in NGF-induced neurite outgrowth, a number of stable PC12 subclones with either very low or considerably enhanced expression levels of the protein were selected. Cell bodies of subclones with suppressed B-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5df4e8b93194cc95c1d6f266f6930c
https://dspace.library.uu.nl/handle/1874/3767

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N-terminal cysteines essential for Golgi sorting of B-50 (GAP-43) in PC12 cells

Autor: A.B. Oestreicher, L. H. J. Aarts, J. A. M. Van Der Linden, Peter Schotman, A.J. van Rozen, W. J. Hage, W.H. Gispen

Publikováno v: Neuroreport, 6, 969. Lippincott Williams & Wilkins

We have examined the subcellular distribution of the growth-associated protein B-50 (GAP-43) in pheochromocytoma (PC12) cells, using confocal microscopy. Proliferating PC12 cells contained very low levels of B-50 in the cytosol. Enhanced expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7591c75a7936dc011cd5beb4502c2f
https://dspace.library.uu.nl/handle/1874/3902

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Phosphoprotein B-50: localization of proteolytic sites for S. aureus V8 protease using truncated cRNAs for cell-free translation

Autor: W.H. Gispen, L.H. Schrama, A.J. van Rozen, Peter Schotman, M. Kasparaitis, H. B. Nielander, A.B. Oestreicher

Publikováno v: Journal of molecular neuroscience : MN. 3(2)

B-50 (= GAP-43, F1, and P-57 or neuromodulin) is a nervous tissue-specific, growth-associated protein, localized in the presynaptic membrane. Phosphorylation by protein kinase C at Ser41 appears to play a role in B-50/calmodulin interaction and neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792e809a0020381b637ce3f6d2ec5d7c
https://pubmed.ncbi.nlm.nih.gov/1726045

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Maladaptive changes in response to a choice diet with fat and sugar

Autor: Roger A.H. Adan, S.E. La Fleur, Lj.M.J. Vanderschuren, A.J. van Rozen, Mieneke C. M. Luijendijk

Publikováno v: Appetite. 49:306

The increased intake of saturated fat and sugar-based beverages has been linked to obesity. It is, therefore, important to study the regulation of consumption of dietary fat and sugar in solution and their role in the development of obesity. We subje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2e9e374f1a60e1bf2b634d4e3f56ca3
https://doi.org/10.1016/j.appet.2007.03.114

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