Zobrazeno 1 - 10
of 212
pro vyhledávání: '"A.J. Shatkin"'
Autor:
Chhaya Dharia, S. Ahmed, Kalyan Das, R. S. K. Vijayan, J.T. Eck, Joseph D. Bauman, Yulia Volovik Frenkel, A.J. Shatkin, D. Patel, W.C. Ho, M.W. Fromer, Eddy Arnold
Publikováno v:
Journal of Medicinal Chemistry. 56:2738-2746
HIV-1 reverse transcriptase (RT) undergoes a series of conformational changes during viral replication and is a central target for antiretroviral therapy. The intrinsic flexibility of RT can provide novel allosteric sites for inhibition. Crystals of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bfdd14e9c98a31edec8f0395ae20e6
https://doi.org/10.1021/jm301271j
https://doi.org/10.1021/jm301271j
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects. 55:277-289
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad56dcab59b764c3b9cd6d8bfa751260
https://doi.org/10.1016/0926-6550(62)90260-8
https://doi.org/10.1016/0926-6550(62)90260-8
Autor:
A.J. Shatkin
Publikováno v:
Biochemical and Biophysical Research Communications. 19:506-510
The addition of 0.5 μg actinomycin/ml to L-929 cell cultures inhibits RNA synthesis 90%; under these same conditions reovirus replication is unaffected.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccc794fecf4518e12a473789ebbdffb
https://doi.org/10.1016/0006-291x(65)90154-3
https://doi.org/10.1016/0006-291x(65)90154-3
Publikováno v:
Biochimica et Biophysica Acta. 45:608-610
The bacteriocidal action of Mitomycin C has been investigated with respect to its biochemical, genetic and morphological correlates. All findings are consistent with the observation that cells treated with Mitomycin lose DNA, but not RNA or protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3d66c70896a9757d851b61adb51e95
https://doi.org/10.1016/0006-3002(60)91504-3
https://doi.org/10.1016/0006-3002(60)91504-3
Autor:
G. E. Brown, M. A. Rebello, Y. Furuichi, G. C. Sen, Peter Lengyel, M. Morgan, B. Lebleu, A.J. Shatkin
Publikováno v:
Biochemical and biophysical research communications. 65(1)
Summary The methylation of (unmethylated) reovirus mRNA is impaired in extracts of interferon-treated Ehrlich ascites tumor cells. The impairment is due to one or more inhibitors. Its extent decreases with an increasing concentration of reovirus mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576f857ca4520e975c6193cf60535fcf
https://pubmed.ncbi.nlm.nih.gov/1147999
https://pubmed.ncbi.nlm.nih.gov/1147999
Autor:
A.J. Shatkin, R.L. Ward
Publikováno v:
Archives of biochemistry and biophysics. 152(1)
Reovirus mRNA molecules released from polysomes of infected cells by EDTA are noncovalently linked. This association which is stable in 1 m NaCl but disrupted by protease treatment, is mediated by viral proteins. The ribonucleoprotein complexes may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2447a3b203b2e3589a4a4e6e84e9295
https://pubmed.ncbi.nlm.nih.gov/4627357
https://pubmed.ncbi.nlm.nih.gov/4627357
Publikováno v:
Biochimica et biophysica acta. 55
The effects of Mitomycin C on two mammalian cell lines, L-929 mouse fibroblast and S-91 mouse melanoma, have been investigated. Appropriate concentrations of the antibiotic caused the formation of giant cells, a large proportion of which showed nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89063b796d5ad5f667e270500d267906
https://pubmed.ncbi.nlm.nih.gov/13911436
https://pubmed.ncbi.nlm.nih.gov/13911436