Zobrazeno 1 - 10 of 34 pro vyhledávání: '"A.J. Lagerwerf"'
1
Steady state bupivacaine plasma concentrations and safety of a femoral “3-in-1” nerve block with bupivacaine in patients over 80 years of age
Autor: A.J. Lagerwerf, M.M.J. Snoeck, Tom B. Vree, Mathieu J.M. Gielen
Publikováno v: Int. Journal of Clinical Pharmacology and Therapeutics. 41:107-113
Objectives Fracture of the upper femur is a common injury in the elderly. Several anesthetic techniques exist for surgery of traumatic hip fracture. The aim of this investigation was to study plasma concentrations and safety of 2 mg/kg bupivacaine in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aee48f21e82fc97a1eed042c11204e
https://doi.org/10.5414/cpp41107
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2
Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case Surgery
Autor: Mathieu J.M. Gielen, A.J. Lagerwerf, Leo H. D. J. Booij, Tom B. Vree, Marc A. M. Simon
Publikováno v: Scientific World Journal, 2, pp. 1298-1311
The Scientific World Journal
Scientific World Journal, 2, 1298-1311
The Scientific World Journal, Vol 2, Pp 1306-1319 (2002)
The aim of this investigation was to compare the clinical effects and pharmacokinetics of lidocaine (one metabolite) and mepivacaine (two metabolites) in 2 groups of 15 patients undergoing axillary brachial plexus anaesthesia. The study had a randomi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e4de52909e888e80657d9c1a7de3e6
https://doi.org/10.1100/tsw.2002.180
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3
High-performance liquid chromatography analysis, preliminary pharmacokinetics, metabolism and renal excretion of methylprednisolone with its C6 and C20 hydroxy metabolites in multiple sclerosis patients receiving high-dose pulse therapy
Autor: A.J. Lagerwerf, P.Jozef H. Jongen, Tom B. Vree, Corrien P. W. G. M. Verwey-Van Wissen
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 732:337-348
A gradient eluent HPLC analysis in human plasma and urine was developed and validated for methylprednisolone (MP), its prodrug methylprednisolone-21-hemisuccinate (MPS) with the metabolites 6beta-hydroxy-6alpha-methylprednisolone (MPA), 20-hydroxymet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3e5f0e689c0271aaf9c91ec02f8eaa
https://doi.org/10.1016/s0378-4347(99)00292-3
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4
High-performance liquid-chromatographic atmospheric pressure chemical-ionization ion-trap mass spectrometric identification of C6-hydroxy and C20-hydroxy metabolites of methylprednisolone in the urine of patients receiving high-dose pulse therapy
Autor: C.P.W.G.M. Verwey-van Wissen, Peter Joseph Jongen, Nico M. M. Nibbering, A.J. Lagerwerf, Robert A. A. Maes, N. Van Den Borg, Tom B. Vree, L. Maljers
Publikováno v: Journal of Pharmacy and Pharmacology, 51, pp. 1155-1166
Journal of Pharmacy and Pharmacology, 51, 1155-1166
Journal of Pharmacy and Pharmacology, 51, 1155-1166. Wiley-Blackwell
Fourteen metabolites of methylprednisolone have been analysed by gradient-elution high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS). The compounds were separated on a Cp Spherisorb 5 μm ODS column connected to a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062fc5c0d77493b08d62de0aafd712a9
https://hdl.handle.net/2066/187572
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5
Technical and biochemical factors affecting cerebrospinal fluid 5-MTHF, biopterin and neopterin concentrations
Autor: A.J. Lagerwerf, Michèl A.A.P. Willemsen, Marcel M. Verbeek, J. van de Geer, Ron A. Wevers, Anna M. Blom
Publikováno v: Molecular Genetics and Metabolism, 95, 127-32
Molecular Genetics and Metabolism, 95, 3, pp. 127-32
Contains fulltext : 70869.pdf (Publisher’s version ) (Closed access) BACKGROUND: The diagnosis of pediatric neurologic disorders with a deficiency in the biosynthesis of either the neurotransmitters serotonin and dopamine, or the co-factor tetrahyd
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aeb56ef2afaa690a9374e796048018c
https://pubmed.ncbi.nlm.nih.gov/18722797
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6
Comparison of the effects and disposition kinetics of lidocaine and (+/-)prilocaine in patients undergoing axillary brachial plexus block during day case surgery
Autor: A.J. Lagerwerf, Tom B. Vree, Leo H. D. J. Booij, Mathieu J.M. Gielen, Marc A. M. Simon
Publikováno v: Clinical drug investigation. 16(3)
The aim of this investigation was to compare the clinical effects and pharmacokinetics of lidocaine and prilocaine in two groups of 15 patients undergoing axillary brachial plexus anaesthesia.The study had a randomised design. Patients were allocated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87a085a355d3d6994145f774dd185dc
https://pubmed.ncbi.nlm.nih.gov/18370545
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7
Recovery and long-term renal excretion of propofol, its glucuronide, and two di-isopropylquinol glucuronides after propofol infusion during surgery
Autor: Tom B. Vree, A.J. Lagerwerf, C.P. Bleeker, P.C.M. Willems-van Bree
Publikováno v: British Journal of Anaesthesia, 101, 207-212
British Journal of Anaesthesia, 101, 2, pp. 207-212
Contains fulltext : 71228.pdf (Publisher’s version ) (Closed access) BACKGROUND: The metabolism of the short-acting anaesthetic agent propofol has been described over the first 24 h. However, the long-term disposition of propofol and its metabolite
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c69e5602869541d29bac92a69143ed
http://hdl.handle.net/2066/71228
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8
Isolation and identification of the C6-hydroxy and C20-hydroxy metabolites and glucuronide conjugate of methylprednisolone by preparative high-performance liquid chromatography from urine of patients receiving high-dose pulse therapy
Autor: Tom B. Vree, A Swolfs, C.P.W.G.M. Verwey-van Wissen, Peter Joseph Jongen, O.R. van Eikema Hommes, Robert A. A. Maes, R. D. Van Ooijen, A.J. Lagerwerf
Publikováno v: Journal of Chromatography. B, 726, 157-168
Journal of Chromatography. B, 726, pp. 157-168
In the present study metabolites of methylprednisolone were detected using gradient elution high-performance liquid chromatography. Separation was performed by a Cp Spherisorb ODS 5 μm (250 mm×4.6 mm I.D.) column, connected to a guard column, packe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86417fb44ea8376b9263c1ae4640250e
https://pubmed.ncbi.nlm.nih.gov/10348182
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9
Explorative pharmacokinetic study of preoperative administration of morphine 50 mg sustained-release capsules (Kapanol) to surgical patients
Autor: Heleen Koppers-Hoyset, Tom B. Vree, Leo H. D. J. Booij, A.J. Lagerwerf
Publikováno v: Clinical Drug Investigation, 18, 125-132
Clinical Drug Investigation, 18, pp. 125-132
Objective: This study investigated the release, absorption and elimination profile of preoperatively administered sustained-release morphine (Kapanol™) and its metabolites in patients undergoing surgery and general anaesthesia.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcaa48155a7b0627a1d5ee0d559ce669
http://hdl.handle.net/2066/155964
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10
Clinical pharmacokinetics of R(+)- and S(-)-mepivacaine after high doses of racemic mepivacaine with epinephrine in the combined psoas compartment/sciatic nerve block
Autor: Tom B. Vree, A.J. Lagerwerf, Erik M. C. Beumer, Mathieu J.M. Gielen, Marc A. M. Simon
Publikováno v: Anesthesia and analgesia. 75(1)
The purpose of this study was to investigate the pharmacokinetics of R(+)- and S(-)-mepivacaine in 10 male patients after injection of a high dose (731 mg) of racemic R,S-mepivacaine for a combined psoas compartment/sciatic nerve block. Arterial bloo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653f5d0170a0f61420cbae7c8adb3e05
https://pubmed.ncbi.nlm.nih.gov/1616166
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