Výsledky vyhledávání - "A.Graeme Shepherd"

Overexpression of the regulatory subunit of γ-glutamylcysteine synthetase in HeLa cells increases γ-glutamylcysteine synthetase activity and confers drug resistance

Autor: Sarah R. Tipnis, David Blake, Lesley I. McLellan, A.Graeme Shepherd

Publikováno v: Biochemical Journal. 337:559-566

γ-Glutamylcysteine synthetase (GCS) is reported to catalyse the rate-limiting step in glutathione biosynthesis, and is a heterodimer composed of a catalytic subunit [heavy subunit (GCSh) of Mr 73000] and a regulatory subunit [light subunit (GCSl) of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baa2fc42573da100291bbdffee315daa
https://doi.org/10.1042/bj3370559

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Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia

Autor: Helen W.L. Ball, Margaret M. Manson, A.Graeme Shepherd, Lesley I. McLellan

Publikováno v: Carcinogenesis. 21(10)

Certain dietary constituents can protect against chemically induced carcinogenesis in rodents. A principal mechanism by which these chemopreventive compounds exert their protective effects is likely to be via induction of carcinogen detoxification. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ebf6ba41f5fcc25edbbb71143ed8c5
https://pubmed.ncbi.nlm.nih.gov/11023540

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