Zobrazeno 1 - 10
of 33
pro vyhledávání: '"A.G.M. Mostofa"'
Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Thymoquinone (TQ), the main bioactive component of Nigella sativa, has been found to exhibit anticancer effects in numerous preclinical studies. Due to its multitargeting nature, TQ interferes in a wide range of tumorigenic processes and counteracts
Externí odkaz:
https://doaj.org/article/0293552e3b864e2cb82e7437ca8feedc
Autor:
John Powers, Tuan P Nguyen, Mark B. Meads, Jason Brayer, David Noyes, Eduardo M. Sotomayor, William S. Dalton, Kenneth L. Wright, Maria D Coelho Siqueira Silva, Allison Distler, Gabriel De Avila, Hongyue A Dai, Eva Sahakian, Oliver A. Hampton, Kenneth H. Shain, Alexandre Tungesvik, John M. Koomen, Praneeth Reddy Sudalagunta, Amit Kulkarni, Raghunandan Reddy Alugubelli, A.G.M. Mostofa, Victoria Izumi, Bin Fang, Ariosto S. Silva, Javier Pinilla-Ibarz, Jamie K. Teer, Eric A. Welsh, Alexandra Achille, Gabriela Wright, Rupal Rampakrishnan, Rafael Renatino Canevarolo
Publikováno v:
JCI Insight
The clinical utility of histone/protein deacetylase (HDAC) inhibitors in combinatorial regimens with proteasome inhibitors for patients with relapsed and refractory multiple myeloma (MM) is often limited by excessive toxicity due to HDAC inhibitor pr
Autor:
Hangping Yao, Chen-Yu Hu, A.G.M. Mostofa, Ming-Hai Wang, Sreedhar Reddy Suthe, Linghui Chen, Weilin Wang, Tianhao Weng, Zhigang Wu, Liang Feng
Publikováno v:
Molecular Pharmaceutics. 15:3260-3271
Aberrant expression of the RON receptor tyrosine kinase, a cell surface protein, is a pathogenic feature in pancreatic cancer, which renders it a drug target for targeted therapy. Nevertheless, development of therapeutics targeting RON for pancreatic
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 305-323 (2018)
Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21cip1 in glioblastoma an
Autor:
A.G.M. Mostofa, Maruf Mohammad Akbor, Muhammad Shahdaat Bin Sayeed, Fabliha Ahmed Chowdhury, Kamal Hossain
Publikováno v:
BioMed Research International, Vol 2018 (2018)
BioMed Research International
BioMed Research International
Glioblastoma multiforme (GBM) is one of the most devastating brain tumors with median survival of one year and presents unique challenges to therapy because of its aggressive behavior. Current treatment strategy involves surgery, radiotherapy, immuno
Autor:
Debasish Basak, George C. Bobustuc, A.G.M. Mostofa, Mohd Aslam Yusuf, Hanumantha Rao Madala, Kalkunte S. Srivenugopal, Nathan I. Bailey, Ameya Paranjpe, Surendra R. Punganuru, Santhi D. Konduri, Francis Ali-Osman
Publikováno v:
Journal of Biomedical Research
Endocrine therapy using estrogen receptor-α (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated with endocrine therapy, we investi
Autor:
Tahiatul Shams, Sharif Mahmood, Muhammad Shahdaat Bin Sayeed, Md. Rezowanur Rahman, Md. Asaduzzaman, Sarder Fahim Hossain, Mohammad Fahim Kadir, A.G.M. Mostofa
Publikováno v:
Journal of Ethnopharmacology. 152:156-162
Ethnopharmacological relevance Previous studies conducted on animals linked consumption of Nigella sativa L. seeds (NS) to decreased anxiety and improved memory. The present study, which was carried out at a boarding school in Bangladesh, was designe
Autor:
A.G.M. Mostofa, Allison Distler, Eva Sahakian, Melissa Alsina, John Powers, Tuan Nguyen, Taiga Nishihori, Rachid Baz, Kenneth H. Shain, Javier Pinilla Ibarz, Eduardo M. Sotomayor, Mark B. Meads, Jason Brayer
Publikováno v:
Blood. 132:3223-3223
Background: Histone deacetylases (HDACs) are potential novel therapeutic targets for multiple myeloma (MM) treatment. A pan-HDAC inhibitor (HDI) panobinostat was approved by the FDA in 2015 to treat relapsed/refractory MM patients, and several other
Autor:
Muhammad Shahdaat Bin Sayeed, A.G.M. Mostofa, Abul Hasnat, Maizbha Uddin Ahmed, Mohammad Safiqul Islam, Md. Rajib Hassan
Publikováno v:
Tumor Biology. 35:1671-1678
The rate of direct smoking, second hand smoking, and smokeless tobacco users as well as the amount of environmental pollutant like polycyclic aromatic hydrocarons is increasing in Bangladesh. Therefore, the prevalence of lung cancer is increasing day
Autor:
A.G.M. Mostofa, Md. Siddiqul Islam, F.M. Touhidul Islam Ferdous, Muhammad Shahdaat Bin Sayeed
Publikováno v:
The Journal of Alternative and Complementary Medicine. 19:767-771
A randomized, single-center, double-blind, crossover clinical trial investigated the effects of an herbal preparation containing Vernonia cinerea in patients with type 2 diabetes mellitus.48 patients with type 2 diabetes mellitus for longer than 6 mo