Výsledky vyhledávání - "A.G. Renwick"

The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis

Autor: Peter S. Friedmann, C.J. Morgan, A.G. Renwick

Publikováno v: The British journal of dermatology. 148(3)

BACKGROUND: Hydrophilic drugs are poorly absorbed when applied topically, due to low partitioning through the lipid matrix of the stratum corneum. Cutaneous blood flow rapidly clears the absorbed drug, which may result in low tissue levels. This is o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d06bff863c51786ae8d554f06b768ee
https://pubmed.ncbi.nlm.nih.gov/12653734

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The pulmonary deposition of two aerosol preparations of nedocromil sodium delivered by MDI assessed by single photon emission computed tomography

Autor: Q.A. Summers, Andrew Reginald Clark, Stephen T. Holgate, John S. Fleming, R. Honeywell, K.J. Gough, Y. Dai, M.A. Nassim, S. Perring, A.G. Renwick

Publikováno v: Europe PubMed Central

The pulmonary deposition and pharmacokinetics of fine and coarse radioactive aerosols of nedocromil sodium, of mass median aerodynamic diameters 16 microns and 24 microns respectively, delivered by metered dose inhaler (MDI) have been investigated. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219394d2df4e5a2c738a9693b79f1e52
https://pubmed.ncbi.nlm.nih.gov/10160062

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Intense sweeteners, food intake, and the weight of a body of evidence

Autor: A.G. Renwick

Publikováno v: Physiologybehavior. 55(1)

A review of published data shows that although intense sweeteners have been shown to increase hunger ratings in some studies in humans, this has not been a consistent and reproducible observation. Any slight effect on perceived hunger has not been tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99adadbae3d66d62a32ad0560f7e07db
https://pubmed.ncbi.nlm.nih.gov/8140158

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Postscript on advantame – A novel high-potency low-calorie sweetener

Autor: A.G. Renwick

Publikováno v: Food and Chemical Toxicology. 49:S1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb72a5349b0749969be9120d8bc24a2
https://doi.org/10.1016/j.fct.2011.06.039

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An analysis of the risk of exceeding the acceptable or tolerable daily intake

Autor: R. Walker, A.G. Renwick

Publikováno v: Regulatory toxicology and pharmacology : RTP. 18(3)

The acceptable or tolerable daily intake (ADI or TDI) for food additives and contaminants is usually derived from chronic animal toxicity studies. The basis for the ADI or TDI is the determination of the no-observed effect level (NOEL) for the most s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc5838338d5c391e6f543b01ff90871
https://pubmed.ncbi.nlm.nih.gov/8128007

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The effects of high dietary concentrations of saccharin on in vitro metabolism of xenobiotics in rats

Autor: G.D. Heaton, A.G. Renwick

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 29(5)

The effects of feeding male rats a diet containing 7.5% sodium saccharin on drug metabolism in vitro were studied using both one- and two-generation protocols. Saccharin administration did not affect the hepatic concentrations of total cytochrome P-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abde68e0d700fe75c0a4ad7435c2d5c5
https://pubmed.ncbi.nlm.nih.gov/2060888

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