Zobrazeno 1 - 10
of 77
pro vyhledávání: '"A.G. Rauws"'
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 18(1)
A rabbit model for simultaneous investigation of the bioavailability, tissue residues and tissue tolerance of intramuscularly administered veterinary medicines is described. The bioavailability of ampicillin from two intramuscular products, which had
Autor:
Marianne Wolthuis, Engelina M. den Tonkelaar, A.G. Rauws, R. Kroes, Hanneke Berkvens, M.J. van Logten, G.J. van Esch
Publikováno v:
Toxicology. 2:257-267
A 90-day toxicity study was carried out in rats on diets containing 0, 75, 300, 1200, 4800 and 19200 ppm sodium bromide. The animals on the highest level did not groom themselves sufficiently and exhibited signs of motor incoordination. The male anim
Publikováno v:
Toxicology and Applied Pharmacology. 35:333-339
After intramuscular injection of the butyrophenone tranquilizer azaperone in pigs, an unknown substance was found at the injection site and in brain, liver and kidney extracts. With the aid of mass spectrometry the substance was identified as a reduc
Publikováno v:
Toxicology and Applied Pharmacology. 66:201-220
The toxicity of two decarboxylase inhibitors, benserazide and carbidopa, was compared in a 90-day study in rats given doses from 32 to 260 mg/kg/day. No mortality directly caused by the drugs occurred. Late growth retardation in the high-dosage bense
Autor:
H.G. Verschuuren, J.M. Berkvens, A.G. Rauws, Engelina M. den Tonkelaar, P.W. Helleman, P.L. Schuller, G.J. van Esch, R. Kroes
Publikováno v:
Toxicology. 6:107-123
Four groups, each of 25 male and 25 female weanling rats, were given dietary levels of 0, 0.1, 0.5 and 2.5 ppm MeHgCl for 2 years. Observations were made on behaviour, growth, food intake, haematology, serum enzymes, urinalysis, microsomal liver enzy
Publikováno v:
Human Toxicology. 1:393-402
1 Bromide, 1 mg kg-1 daily, was administered to 21 healthy volunteers (11 females not using oral contraceptives and not pregnant and 10 males, during 8 weeks or 2 full cycles to determine whether ingestion of a dose equal to the acceptable daily inta
Autor:
A.G. Rauws, M.J. van Logten
Publikováno v:
Toxicology. 1:29-41
Chickens were exposed to dichlorvos vapour from strips continually or intermittently for three weeks. During exposure dichlorvos in air and cholinesterase activity in plasma were determined. At the end brain-acetyl-cholinesterase activity was assayed
Publikováno v:
Virology. 23:283-286
Publikováno v:
Toxicology. 1:321-327
Five groups, each of 4 female rats, received for 4 weeks either a standard diet or diets containing 300, 1200, 4800 or 19 200 ppm sodium bromide. The rats receiving 19 200 ppm sodium bromide did not clean themselves sufficiently and showed signs of m
Autor:
A.G. Rauws
Publikováno v:
Toxicology. 4(2)
Using data obtained from pharmacokinetic experiments with bromide, illustrations are given of the application of pharmacokinetics to toxicological studies. Analog computers may be helpful, though not indispensable. The significance of ancillary pharm