Zobrazeno 1 - 10
of 26
pro vyhledávání: '"A.F. Esmail"'
Publikováno v:
Thrombosis Research. 59:687-692
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f71c8b00fecd4ed37d97f4b133488c8
https://doi.org/10.1016/0049-3848(90)90429-g
https://doi.org/10.1016/0049-3848(90)90429-g
Publikováno v:
Fibrinolysis. 4:87-94
The potency and selectivity of tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activators have been compared in a guinea pig pulmonary embolism model. Radiolabelled human whole blood clots were embolised to the lungs and the animals suppleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71185abef4e4a0b19d4035239439169a
https://doi.org/10.1016/0268-9499(90)90003-3
https://doi.org/10.1016/0268-9499(90)90003-3
Publikováno v:
Thrombosis and Haemostasis. 63:459-463
SummaryA hybrid plasminogen activator consisting of the “A” chain of plasmin linked to the “B” chain of rt-PA was inhibited in vitro in human and guinea pig plasmas 4 to 5-fold more rapidly than its parent activator, two-chain t-PA. Using zym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7037b891c19b9a3528c1d1bcd9207615
https://doi.org/10.1055/s-0038-1645066
https://doi.org/10.1055/s-0038-1645066
Autor:
R. A. G. Smith, D. W. Cronk, C. Entwisle, S. Wilson, J. H. Robinson, S. B. Kalindjian, C.G. Chapman, G.M.P. Lawrence, P. D. Chamberlain, M.J. Browne, A.F. Esmail, L. McMurdo, J.E. Carey, I. Dodd, D.L. Mitchell
Publikováno v:
Journal of Chemical Technology & Biotechnology. 57:286-287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa715c48749cc80dcde6ddb2e77f1f9
https://doi.org/10.1002/jctb.280570317
https://doi.org/10.1002/jctb.280570317
Autor:
Ian B. Dodd, A.F. Esmail, J.E. Carey, S. B. Kalindjian, C. Entwisle, J H Robinson, P. D. Chamberlain, C.G. Chapman, M J Browne, D. W. Cronk
Publikováno v:
Circulation. 86(2)
BACKGROUND Early intervention with thrombolytic agents has been shown unequivocally to reduce mortality after acute myocardial infarction. Presently used agents have disadvantages such as short half-life, immunogenicity, hypotension, and bleeding com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928934490922f4d938e7e68dfb23588a
https://pubmed.ncbi.nlm.nih.gov/1638720
https://pubmed.ncbi.nlm.nih.gov/1638720
Autor:
A.F. Esmail, J.H. Robinson
Publikováno v:
European Journal of Pharmacology. 183:2017
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12387f7563946b477951ae94385c4286
https://doi.org/10.1016/0014-2999(90)92376-t
https://doi.org/10.1016/0014-2999(90)92376-t
Autor:
J H Robinson, C. Entwisle, G.M.P. Lawrence, C.G. Chapman, A.W.R. Tyrrell, M.J. Browne, B. Reavy, Ian B. Dodd, A.F. Esmail, J.E. Carey
Publikováno v:
Journal of Biological Chemistry. 263:1599-1602
The complete cDNA for human tissue-type plasminogen activator (t-PA) was cloned and sequenced. A mutant was constructed by using in vitro site-specific mutagenesis to delete the region encoding the growth factor domain (amino acids 51-87 inclusive).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cddcdecab7dc3551cbe16f1457c67ef
https://doi.org/10.1016/s0021-9258(19)77918-6
https://doi.org/10.1016/s0021-9258(19)77918-6
Publikováno v:
Fibrinolysis. 3:207-214
The fibrinolytic enzyme tissue-type plasminogen activator (t-PA) exhibits a short plasma half-life in vivo. We have used a series of modified t-PA species to investigate the role of the A-chain domains, i.e. finger (F), growth factor (G) and kringles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d038a0d93c5c751ffb89bf3d76a5da6d
https://doi.org/10.1016/0268-9499(89)90048-9
https://doi.org/10.1016/0268-9499(89)90048-9
Autor:
A.J. Sweetman, A.F. Esmail
Publikováno v:
Biochemical and biophysical research communications. 64(3)
Alphaxalone, the major component of the steroid anaesthetic, Althesin, inhibited the uptake of 45 Ca 2+ into mitochondria isolated from rat brain. The subcellular distribution of calcium in the brain was measured after intraperitoneal injection of 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1fdaa46a13090302dce0c0cd3f7b59
https://pubmed.ncbi.nlm.nih.gov/1147969
https://pubmed.ncbi.nlm.nih.gov/1147969
Autor:
C. Entwisle, A.F. Esmail, I. Dodd, J.E. Carey, B. Reavy, C.G. Chapman, A.W.R. Tyrrell, M.J. Browne, G.M.P. Lawrence, J.H. Robinson
Publikováno v:
Fibrinolysis. 2:31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76869796b542ebc7986b9e2f5438260e
https://doi.org/10.1016/0268-9499(88)90412-2
https://doi.org/10.1016/0268-9499(88)90412-2