Výsledky vyhledávání - "A.E.M. Holthuysen"

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis

Autor: Peter L E M van Lent, Nico van Rooijen, A.E.M. Holthuysen, Johannes Roth, Wim B. van den Berg, Peter M. van der Kraan, Arjen B. Blom

Publikováno v: Blom, A B, van Lent, P L, Holthuysen, A E, van der Kraan, P M, Roth, J, van Rooijen, N & Berg, W B 2004, ' Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis ', Osteoarthritis and Cartilage, vol. 12, pp. 627-635 . https://doi.org/10.1016/j.joca.2004.03.003
Osteoarthritis and Cartilage, 12, 627-35
Osteoarthritis and Cartilage, 12, 627-635. W.B. Saunders Ltd
Osteoarthritis and Cartilage, 12, 8, pp. 627-35

Contains fulltext : 57170.pdf (Publisher’s version ) (Closed access) OBJECTIVE: In human osteoarthritis (OA), various forms of pathology are observed. Besides cartilage damage and fibrosis, neogenesis of bone, osteophyte formation, also occurs. Ost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a723ea4f4b573284585473a293793a
https://doi.org/10.1016/j.joca.2004.03.003

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FcγRI Up-Regulation Induced by Local Adenoviral-Mediated Interferon-γ Production Aggravates Chondrocyte Death during Immune Complex-Mediated Arthritis

Autor: K. C. A. M. Nabbe, Peter L E M van Lent, A.E.M. Holthuysen, Jay K. Kolls, Wim B. van den Berg, Sjef Verbeek

Publikováno v: American Journal of Pathology, 163, 743-52
American Journal of Pathology, 163, 2, pp. 743-52

Item does not contain fulltext Using various FcgammaR-deficient mice, we have obtained suggestive evidence that FcgammaRI on macrophages is responsible for severe cartilage destruction during arthritis mediated by immune complexes (ICs). This role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d873b40a2f8582153e1b07dcf060b77b
https://doi.org/10.1016/s0002-9440(10)63701-7

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Skewed balance in basal expression and regulation of activating v inhibitory Fcgamma receptors in macrophages of collagen induced arthritis sensitive mice

Autor: A.E.M. Holthuysen, Andreas Blom, C.W.M. Jacobs, P.L.E.M. van Lent, W.B. van den Berg

Publikováno v: Annals of the Rheumatic Diseases, 62, 465-71
Annals of the Rheumatic Diseases, 62, 5, pp. 465-71

Item does not contain fulltext BACKGROUND: Recently, it has been found that collagen type II arthritis susceptible mouse strains are hyperreactive to immune complexes (ICs), locally deposited into their knee joints. OBJECTIVE: To investigate whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6863748e02bc9441ea5467fe111ff61
https://doi.org/10.1136/ard.62.5.465

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The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes

Autor: Arjen B. Blom, Johannes Roth, Peter Boross, Annet W. Sloetjes, Peter L E M van Lent, Sjef Verbeek, K. C. A. M. Nabbe, Wim B. van den Berg, A.E.M. Holthuysen

Publikováno v: American Journal of Pathology, 163, 5, pp. 1839-48
American Journal of Pathology, 163, 1839-48

Item does not contain fulltext Studies of FcgammaRII-/- mice identified the inhibitory function of this receptor in joint inflammation and cartilage destruction induced with immune complexes (ICs). To extend our insight in the role of FcgammaRII in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc217a683827045a6ecd9afa3df4411
https://hdl.handle.net/2066/142103

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Uptake of apoptotic leukocytes by synovial lining macrophages inhibits immune complex-mediated arthritis

Autor: H.B.P.M. Dijkman, W.B. van den Berg, A.E.M. Holthuysen, Jhm Berden, P.L.E.M. van Lent, R. Licht

Publikováno v: Journal of Leukocyte Biology, 70, 5, pp. 708--14
Journal of Leukocyte Biology, 70, 708--14

Previously we have shown that synovial lining macrophages (SLMs) determine the onset of experimental immune complex–mediated arthritis (ICA). During joint inflammation, many leukocytes undergo apoptosis, and removal of leukocytes by SLMs may regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb31684393cbe97ec63eaf90f493425
https://hdl.handle.net/2066/141931

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FcgammaR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)

Autor: A.E.M. Holthuysen, Wim B. van den Berg, Leo B A van de Putte, Arjen B. Blom, Cor Jacobs, Jan G. J. van de Winkel, Peter L E M van Lent, Hanneke van Vuuren

Publikováno v: Arthritis Research

We investigated the role of Fcγ receptors (FcγRs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA elicited in knee joints of C57BL/6 mice caused a short-lasting, florid inflammation and reversible loss of proteoglycans (PGs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393103a1d5a989a88e54bba2fd338b77
http://europepmc.org/articles/PMC17821

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Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: A pivotal role for stromelysin 1 in matrix metalloproteinase activity

Autor: Ellen K. Bayne, Robin Poole, Wim B. van den Berg, Clark Billinghurst, John S. Mudgett, Pieter Buma, Peter L E M van Lent, Irwin I. Singer, Peter M. van der Kraan, A.E.M. Holthuysen, Reinout Stoop, Joyce B. J. van Meurs

Publikováno v: Arthritis & Rheumatism. 42:2074-2084

Objective The destruction of articular cartilage during arthritis is due to proteolytic cleavage of the extracellular matrix components. This study investigates the kinetic involvement of metalloproteinases (MMPs) in the degradation of the 2 major ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d902699a6a27434857d3b5b200bf7d37
https://doi.org/10.1002/1529-0131(199910)42:10<2074::aid-anr7>3.0.co

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Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis

Autor: Joyce B. J. van Meurs, Wim B. van den Berg, Peter L E M van Lent, A.E.M. Holthuysen, Ellen K. Bayne, Irwin I. Singer

Publikováno v: Arthritis & Rheumatism. 42:1128-1139

Objective Two major cleavage sites, one mediated by metalloproteinases (MMPs) and the other by an as-yet unidentified enzyme termed aggrecanase, have been observed in aggrecan. To learn more about the relative contribution of these enzymes during car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33781043d653c5191cb004d8b3a72851
https://doi.org/10.1002/1529-0131(199906)42:6<1128::aid-anr9>3.0.co

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Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis

Autor: N. van Rooijen, P.L.E.M. van Lent, A.E.M. Holthuysen, L. B. A. Van De Putte, W.B. van den Berg

Publikováno v: Annals of the Rheumatic Diseases, 57, pp. 408-413
Annals of the Rheumatic Diseases, 57, 408-413

OBJECTIVE—To investigate whether local removal of phagocytic synovial lining cells (SLCs) from the knee joint before onset of collagen type II arthritis has an effect on development of cartilage destruction. METHODS—Phagocytic SLCs were selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5229667a1e33ad7443bb34c4aa24e47
https://doi.org/10.1136/ard.57.7.408

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