Zobrazeno 1 - 10
of 41
pro vyhledávání: '"A.D. Watters"'
Publikováno v:
BJU International. 89:5-9
Objective To determine the frequency of HER2 genetic abnormalities in renal cell carcinoma (RCC) and hence assess the potential suitability of Herceptin™ immunotherapy. Patients and methods Tumours from 27 patients with RCC were assessed; all patie
Autor:
Timothy G. Cooke, A.D. Watters, Jorma Isola, Amanda Forsyth, John M. S. Bartlett, Minna Tanner
Publikováno v:
Clinical Cancer Research. 10:4793-4798
Purpose: Chromogenic in situ hybridization (CISH) is a new modification of the fluorescence in situ hybridization (FISH) technique for detection of oncogene amplification in archival tumor samples. In CISH, the oncogene probe is detected using a pero
Publikováno v:
European Journal of Cancer. 40:56-63
HER2/neu is an oncogene encoding a type 1 tyrosine kinase growth factor receptor. Polysomy 17, gene amplification and HER2/neu protein overexpression are associated with a poor prognosis in transitional cell carcinomas (TCC) of the bladder. Due to th
Autor:
P. Wencyk, Timothy G. Cooke, Sarah E Pinder, Mitch Dowsett, John M. S. Bartlett, Ian O. Ellis, Janine Salter, Elizabeth Mallon, Margaret Hills, A.D. Watters, C. Paish
Publikováno v:
The Journal of Pathology. 199:418-423
Accurate diagnostic assessment of HER-2 is essential for the appropriate application of the humanized anti-HER-2 monoclonal antibody trastuzumab (Herceptin) to the treatment of patients with metastatic breast cancer. The diagnostic test needs to be a
Publikováno v:
Breast Cancer Research and Treatment. 77:109-114
Aberrations of chromosome 17 are common in breast cancer. Fluorescence in situ hybridization (FISH) enables gene or chromosome copy number to be assessed in situ in archival tissues and related to morphology and clinical outcome. In this study direct
Autor:
A Forsyth, K. M. Grigor, John M. S. Bartlett, Ian F. Dunn, Mark A. Underwood, Z Latif, A.D. Watters
Publikováno v:
British Journal of Cancer
Detrusor muscle invasive transitional cell carcinoma is associated with poor prognosis and is responsible for the majority of bladder cancer related deaths. Amplifications of c-myc and CCND1 are associated with detrusor-muscle-invasive transitional c
Autor:
A.D. Watters, John M. S. Bartlett
Publikováno v:
Molecular Biotechnology. 21:217-220
Fluorescence in situ hybridization has found wide application in the enumeration of gene and chromosome copy number both in isolated cells and in tissue sections. However, the technique has been less widely used than would be expected in formalin-fix
Autor:
Kenneth M. Grigor, A.D. Watters, James J. Going, Joanne Edwards, John M. S. Bartlett, Pamela Duncan
Publikováno v:
The Journal of Pathology. 196:380-385
Following an earlier study linking monosomy 9 with recurrence of transitional cell carcinomas (TCCs) of the urinary bladder, 109 primary and recurrent TCCs (from 47 patients) were examined to explore genetic alterations at chromosome 9 associated wit
Autor:
K. M. Grigor, Michael W. Stacey, Timothy G. Cooke, John M. S. Bartlett, A.D. Watters, James J. Going, E. Sim
Publikováno v:
Urologia Internationalis. 67:235-239
Introduction/Objective: N-acetyltransferase 2 (NAT2), mapped to 8p22, is a polymorphic enzyme which metabolizes aromatic amines. Loss of heterozygosity of 8p22 is associated with an increased risk of bladder cancer. This study evaluated NAT2 and chro
Autor:
Elizabeth Mallon, P D Stanton, A.D. Watters, J.R. Reeves, John M. S. Bartlett, Brian Donald, Timothy G. Cooke, Jim Richmond, James J. Going, Rhona Ferrier
Publikováno v:
The Journal of Pathology. 195:422-428
The development of Herceptin (Trazumatab) makes testing for HER2 status important for choosing optimal therapy in breast cancer. This study addresses the precision, accuracy, and reproducibility of HER2 assays. HER2 was assessed retrospectively by im