Zobrazeno 1 - 10
of 524
pro vyhledávání: '"A.D. Roses"'
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 4, Pp 611-625 (2001)
The apolipoprotein E (APOE) ϵ4 allele is a major risk factor for late-onset familial and sporadic Alzheimer's disease (AD) and is associated with a poor outcome after brain injury. Each apoE isoform is suggested to have differential effects on neuro
Externí odkaz:
https://doaj.org/article/c1087cc3b45f48cdb5710324cb7a20c5
Publikováno v:
Neurobiology of Disease, Vol 6, Iss 6, Pp 508-514 (1999)
In the adult brain, apolipoprotein E (apoE) mRNA is thought to be expressed by nonneuronal cells. Yet, when a brain damage has occurred, the protein is found in neurons. We have studied apoE expression following systemic kainic acid (KA), injected in
Externí odkaz:
https://doaj.org/article/799f29e38162464da6f56ee10cce172a
Publikováno v:
Neuroscience. 121:315-325
Apolipoprotein E (apoE4) and head trauma are important genetic and environmental risk factors for Alzheimer's disease. Furthermore, apoE4 increases both the acute and chronic consequences of head trauma. The latter are associated with the deposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8898931890f256249286e559b8c4ccad
https://doi.org/10.1016/s0306-4522(03)00436-6
https://doi.org/10.1016/s0306-4522(03)00436-6
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of ag
Autor:
R.P.M. van Gijlswijk, B. Horsthemke, K. Buiting, Y. Nobukuni, P.M.A. Groenen, J.-E. Ikeda, L. Sánchez, J.A. Tischfield, N.C. Stowell, J. Castro, P.M. Kroisel, E.H. Goodwin, M. Zanetti, S.M. Jhiang, C.M. Kammerer, M.N. Cornforth, A. Viñas, T.S. McConnell, C. Shao, S. Kajigaya, A.A. Perelygin, A. Besner-Johnston, R.G. Korneluk, J.P. Fryns, K. Devriendt, J.F. Cheng, C. Lefebvre, Q. Tong, P. Martínez, N. Iwata, Q. Duh, W.J.M. Van de Ven, B. Castiglioni, A. Sahota, A. Watanabe, B. O’Brien, O.H. Clark, J. Rogers, B. Ploplis, E. Rajcan-Separovic, A.J.M. Roebroek, A. MacKenzie, R. Thoelen, Constantinos Deltas, G.H. Jossart, L. Ferretti, J. Wiegant, S.M. Bailey, J.-W.H.P. van de Loo, P.C. Patsalis, A.D. Roses, J.W.M. Creemers, S. Munné, S. Kaya-Westerloh, P.A. loannou, H.-U.G. Weier, Y. Sun, E.F.P.M. Schoenmakers, M. Tachibana, P.K. Gupta, M. Aly, A.K. Raap, R. Vervenne, J. Meyne, K. Kas, M. Hadjimarcou, H.J. Tanke, M. Scocchi, E. Garcia, J.E. Lee, M.S. Mahadevan, R. Lasan, E. Bashiardes
Publikováno v:
Cytogenetic and Genome Research. 75:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4a7f88d96c136c08859ec5a1b0fe1f
https://doi.org/10.1159/000134483
https://doi.org/10.1159/000134483
Autor:
J.L. Haines, M. Ter-Minassian, A. Bazyk, J.F. Gusella, D.J. Kim, H. Terwedow, M.A. PericakVance, J.B. Rimmler, C.S. Haynes, A.D. Roses, A. Lee, B. Shaner, M. Menold, E. Seboun, R-P. Fitoussi, C. Gartioux, C. Reyes, F. Ribierre, G. Gyapay, J. Weissenbach, S.L. Hauser, D.E. Goodkin, R. Lincoln, K. Usuku, A. Garcia-Merino, N. Gatto, S. Young, J.R. Oksenberg
Publikováno v:
Nature Genetics. 13:469-471
Multiple sclerosis (MS), an inflammatory autoimmune demyelinating disorder of the central nervous system, is the most common cause of acquired neurological dysfunction arising in the second to fourth decades of life1,2. A genetic component to MS is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed77f23202aba9f84dbc3fb077075c3
https://doi.org/10.1038/ng0896-469
https://doi.org/10.1038/ng0896-469
Autor:
T Sabo, S.M Beni, Robert R. Maronpot, A.D Roses, L. Lomnitski, Esther Shohami, Daniel M. Michaelson, Abraham Nyska
Publikováno v:
Neuroscience. 101(4)
Apolipoprotein E, the major brain lipid-binding protein, is expressed in humans as three common isoforms (E2, E3 and E4). Previous studies revealed that the allele apolipoprotein E4 is a major genetic risk factor of Alzheimer’s disease and that tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c831714d0307961a5fa24d2de988986c
https://pubmed.ncbi.nlm.nih.gov/11113336
https://pubmed.ncbi.nlm.nih.gov/11113336
Publikováno v:
Neuroscience. 97(3)
Apolipoprotein E genotype is an important risk factor of Alzheimer's disease, which is associated with the degeneration of distinct brain neuronal systems. In the present study we employed apolipoprotein E-deficient mice and human apolipoprotein E3 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c35d1848a40c9cf0a326a572d37922e
https://pubmed.ncbi.nlm.nih.gov/10828524
https://pubmed.ncbi.nlm.nih.gov/10828524
Publikováno v:
Apolipoprotein E and Alzheimer’s Disease ISBN: 9783642801112
The type 4 allele of apolipoprotein E (APOE, gene; apoE, protein) has been identified as a genetic risk factor for late-onset sporadic and familial Alzheimer’s disease (AD). APOE4 raises the risk for AD and lowers the mean age of onset in a gene do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23b364f7f1b46ee1d0ed551f5a88f21
https://doi.org/10.1007/978-3-642-80109-9_12
https://doi.org/10.1007/978-3-642-80109-9_12