Zobrazeno 1 - 10
of 27
pro vyhledávání: '"A.D. Rathnayake"'
Autor:
Scott Lovell, Harry Nhat Nguyen, Kyeong-Ok Chang, Kevin P. Battaile, Jian Zheng, Stanley Perlman, Matthew A. Baird, Maithri M. Kashipathy, Naemi Bickmeier, Chamandi S Dampalla, A.D. Rathnayake, William C. Groutas, Yunjeong Kim
Publikováno v:
Journal of Medicinal Chemistry
A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors that incorporate in their structure a conformationally constrained cyclohexane moiety was synthesized and found to potently inhibit severe acute respiratory s
Autor:
William C. Groutas, Harry Nhat Nguyen, Chamandi S Dampalla, A.D. Rathnayake, Yunjeong Kim, Kyeong-Ok Chang, Kevin P. Battaile, Maithri M. Kashipathy, Scott Lovell, Abdul-Rahman M Jesri, Gerald H. Lushington
Publikováno v:
Journal of Medicinal Chemistry. 63:11945-11963
Acute gastroenteritis caused by noroviruses has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The disease impacts most severely immunocompromised patients, the elderly, and children. The current lack
Autor:
Krishani Dinali Perera, Stanley Perlman, Scott Lovell, Kyeong-Ok Chang, Maithri M. Kashipathy, David K. Meyerholz, A.D. Rathnayake, William C. Groutas, Samantha R. Mackin, Jian Zheng, Yunjeong Kim, Kevin P. Battaile
Publikováno v:
Science Translational Medicine
Optimized small-molecule 3C-like protease inhibitors show potency against human coronaviruses in both cell culture and a mouse model.
Targeting coronavirus 3CLpro Coronavirus 3C-like proteases (3CLpro) are attractive therapeutic targets because
Targeting coronavirus 3CLpro Coronavirus 3C-like proteases (3CLpro) are attractive therapeutic targets because
Autor:
Scott Lovell, Vishnu C. Damalanka, Kyeong-Ok Chang, William C. Groutas, Anthony R. Fehr, A.D. Rathnayake, Stanley Perlman, N. Mehzabeen, Gerald H. Lushington, Yunjeong Kim, Anushka C. Galasiti Kankanamalage, Kevin P. Battaile
Publikováno v:
European Journal of Medicinal Chemistry
There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential for viral replication; conseq
Autor:
Anushka C. Galasiti Kankanamalage, Steven C. Cardinale, A.D. Rathnayake, Michelle M. Butler, William C. Groutas, Terry L. Bowlin, Yunjeong Kim, Kyeong-Ok Chang, Kevin R. Alliston
Publikováno v:
Journal of Medicinal Chemistry. 60:6239-6248
Ester and carbamate prodrugs of aldehyde bisulfite adduct inhibitors were synthesized in order to improve their pharmacokinetic and pharmacodynamic properties. The inhibitory activity of the compounds against norovirus 3C-like protease in enzyme and
Autor:
William C. Groutas, Anushka C. Galasiti Kankanamalage, Kyeong-Ok Chang, N. Mehzabeen, D. M.Padmasankha Dissanayake, Vishnu C. Damalanka, Sean T. Doyle, Gerald H. Lushington, Yunjeong Kim, Scott Lovell, Amer F. Alsoudi, A.D. Rathnayake, Kevin P. Battaile, Pathum M. Weerawarna
Publikováno v:
European Journal of Medicinal Chemistry
Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitu
Publikováno v:
Viruses, Vol 11, Iss 2, p 197 (2019)
Viruses
Viruses
Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; consequently, host proteases have
Autor:
A.D. Rathnayake, N. Mehzabeen, William C. Groutas, Yunjeong Kim, Pathum M. Weerawarna, Kyeong-Ok Chang, Kevin P. Battaile, Anushka C. Galasiti Kankanamalage, Scott Lovell
Publikováno v:
Proteins
Human noroviruses are the primary cause of outbreaks of acute gastroenteritis worldwide. The problem is further compounded by the current lack of norovirus-specific antivirals or vaccines. Noroviruses have a single-stranded, positive sense 7–8 kb R
Autor:
William C. Groutas, Kyeong-Ok Chang, Amanda Honeyfield, A.D. Rathnayake, Anushka C. Galasiti Kankanamalage, Yunjeong Kim, Krishani Dinali Perera
Publikováno v:
Antiviral Research
Ferret and mink coronaviruses typically cause catarrhal diarrhea in ferrets and minks, respectively. In recent years, however, systemic fatal coronavirus infection has emerged in ferrets, which resembles feline infectious peritonitis (FIP) in cats. F
Autor:
Harry Nhat Nguyen, Vishnu C. Damalanka, Gerald H. Lushington, Kevin P. Battaile, Yunjeong Kim, A.D. Rathnayake, Kyeong-Ok Chang, William C. Groutas, Scott Lovell, Anushka C. Galasiti Kankanamalage, N. Mehzabeen
Acute nonbacterial gastroenteritis caused by noroviruses constitutes a global public health concern and a significant economic burden. There are currently no small molecule therapeutics or vaccines for the treatment of norovirus infections. A structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10da3baa2b9089ecb8fc5afd0b6c19f5
https://europepmc.org/articles/PMC5737831/
https://europepmc.org/articles/PMC5737831/