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pro vyhledávání: '"A.C. Laan"'
Akademický článek
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Autor:
A.C. Laan, C. J. van Groeningen, R. Ruyter, J. M. G. H. Van Riel, Richard J. Honeywell, Lemonitsa H. Mammatas, F.G. van den Berg, G.J. Peters, G. Giaccone
Publikováno v:
European Journal of Cancer, 45(14), 2519-2527. Pergamon
van Riel, J M G H, Peters, G J, Mammatas, L H, Honeywell, R J, Laan, A C, Ruijter, R, van den Berg, F G, Giaccone, G & van Groeningen, C J 2009, ' A phase I and pharmacokinetic study of gemcitabine given by 24-h hepatic arterial infusion ', European Journal of Cancer, vol. 45, no. 14, pp. 2519-2527 . https://doi.org/10.1016/j.ejca.2009.05.025
van Riel, J M G H, Peters, G J, Mammatas, L H, Honeywell, R J, Laan, A C, Ruijter, R, van den Berg, F G, Giaccone, G & van Groeningen, C J 2009, ' A phase I and pharmacokinetic study of gemcitabine given by 24-h hepatic arterial infusion ', European Journal of Cancer, vol. 45, no. 14, pp. 2519-2527 . https://doi.org/10.1016/j.ejca.2009.05.025
This study was performed to assess the toxicities, the maximum-tolerated dose (MTD), the pharmacokinetics and the anti-tumour activity of gemcitabine given by 24-h hepatic arterial infusion (HAI).Patients with liver malignancies received gemcitabine
Autor:
Giuseppe Giaccone, Clemens M F Dirven, J.C.A. Baayen, C.J. van Groeningen, K. van der Born, G.J. Peters, J. Sigmond, S.M. de Lange, Richard J. Honeywell, Tjeerd J. Postma, Andre M. Bergman, A.C. Laan
Publikováno v:
Sigmond, J, Honeywell, R J, Postma, T J, Dirven, C M, de Lange, S M, van der Born, K, Laan, A, Baayen, J C, van Groeningen, C J, Bergman, A M, Giaccone, G & Peters, G J 2009, ' Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer ', Annals of Oncology, vol. 20, no. 1, pp. 182-187 . https://doi.org/10.1093/annonc/mdn543
Annals of Oncology, 20(1), 182-187. Elsevier Ltd.
Annals of Oncology, 20(1), 182-187. Oxford University Press
Annals of Oncology, 20(1), 182-187. Elsevier Ltd.
Annals of Oncology, 20(1), 182-187. Oxford University Press
Glioblastoma multiforme (GBM), the most frequent malignant brain tumor, has a poor prognosis, but is relatively sensitive to radiation. Both gemcitabine and its metabolite difluorodeoxyuridine (dFdU) are potent radiosensitizers. The aim of this phase
Publikováno v:
Bijnsdorp, I V, de Bruin, M, Laan, A C, Fukushima, M & Peters, G J 2008, ' The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior ', Nucleosides, Nucleotides and Nucleic Acids, vol. 27, no. 6, pp. 681-691 . https://doi.org/10.1080/15257770802143988
Nucleosides, Nucleotides and Nucleic Acids, 27(6), 681-691. Taylor and Francis Ltd.
Nucleosides, Nucleotides and Nucleic Acids, 27(6), 681-691. Taylor and Francis Ltd.
Platelet-derived endothelial cell growth-factor (PD-ECGF) is similar to the pyrimidine enzyme thymidine phosphorylase (TP). A high TP expression at tumor sites is correlated with tumor growth, induction of angiogenesis, and metastasis. Therefore, hig
Autor:
Annelies W. Turksma, P. Noordhuis, M. de Bruin, A.C. Laan, Allan J. Masterson, Olaf H. Temmink, G.J. Peters, S. Cricca
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 38:1759-1765
Thymidine phosphorylase (TP) and uridine phosphorylase (UP) catalyze the (in)activation of several fluoropyrimidines, depending on their catalytic activity and substrate specificity. Blood cells are the first compartment exposed to most anticancer ag
Autor:
Jan Hendrik Hooijberg, Godefridus J. Peters, Ietje Kathmann, Gertjan J.L. Kaspers, Gerrit Jansen, Rob Pieters, A.C. Laan, Ina van Zantwijk
Publikováno v:
Cancer Chemotherapy and Pharmacology, 73(5), 911-917. Springer Verlag
Cancer Chemotherapy & Pharmacology, 73(5), 911-917. Springer-Verlag
Hooijberg, J H, Jansen, G, Kathmann, I, Pieters, R, Laan, A C, van Zantwijk, I, Kaspers, G J L & Peters, G J 2014, ' Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1) ', Cancer Chemotherapy and Pharmacology, vol. 73, no. 5, pp. 911-917 . https://doi.org/10.1007/s00280-014-2421-0
Cancer Chemotherapy & Pharmacology, 73(5), 911-917. Springer-Verlag
Hooijberg, J H, Jansen, G, Kathmann, I, Pieters, R, Laan, A C, van Zantwijk, I, Kaspers, G J L & Peters, G J 2014, ' Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1) ', Cancer Chemotherapy and Pharmacology, vol. 73, no. 5, pp. 911-917 . https://doi.org/10.1007/s00280-014-2421-0
Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1). Since MRP1 mediates resistance to a variety of therapeutic drugs, we investigated whether the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4315c2adc8d7663e2c52c9a20a47f98
https://research.vumc.nl/en/publications/e2e40c7c-2749-4832-bd92-5e2bf1c2a1f2
https://research.vumc.nl/en/publications/e2e40c7c-2749-4832-bd92-5e2bf1c2a1f2
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Finn Myhren, Marit Liland Sandvold, A.C. Laan, H.M.W. Verheul, Godefridus J. Peters, A.D. Adema, Iduna Fichtner
Publikováno v:
International Journal of Oncology 36 (1): 285-294.
Adema, A D, Laan, AC, Myhren, F, Fichtner, I, Verheul, H M W, Sandvold, ML & Peters, G J 2010, ' Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel ', International Journal of Oncology, vol. 36, no. 1, pp. 285-294 . https://doi.org/10.3892/ijo_00000499
International Journal of Oncology, 36(1), 285-294. Spandidos Publications
Adema, A D, Laan, AC, Myhren, F, Fichtner, I, Verheul, H M W, Sandvold, ML & Peters, G J 2010, ' Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel ', International Journal of Oncology, vol. 36, no. 1, pp. 285-294 . https://doi.org/10.3892/ijo_00000499
International Journal of Oncology, 36(1), 285-294. Spandidos Publications
To bypass resistance due to limited entry into the cell derivatives of cytarabine (CP-4055, elacytarabine) and gemcitabine (CP-4126) containing a fatty acid chain at the 5' position of the nucleoside were developed. CP-4055 showed an increased retent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef7f3fdc54ec281b799ab85bef24005
http://edoc.mdc-berlin.de/10596/
http://edoc.mdc-berlin.de/10596/
Autor:
Elisa Giovannetti, Cecilia Ceresa, Richard J. Honeywell, Jens Voortman, Godefridus J. Peters, Giuseppe Giaccone, A.C. Laan
Publikováno v:
Molecular Cancer Therapeutics, 8(5), 1026-1036. American Association for Cancer Research Inc.
Ceresa, C, Giovannetti, E, Voortman, J, Laan, A, Honeywell, R J, Giaccone, G & Peters, G J 2009, ' Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells ', Molecular Cancer Therapeutics, vol. 8, no. 5, pp. 1026-1036 . https://doi.org/10.1158/1535-7163.MCT-08-0700
Ceresa, C, Giovannetti, E, Voortman, J, Laan, A, Honeywell, R J, Giaccone, G & Peters, G J 2009, ' Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells ', Molecular Cancer Therapeutics, vol. 8, no. 5, pp. 1026-1036 . https://doi.org/10.1158/1535-7163.MCT-08-0700
Bortezomib combination with gemcitabine/cisplatin in patients with advanced tumors, predominantly non-small cell lung cancer (NSCLC), showed an unexpected transient drop in the deoxycytidine plasma levels, a marker for gemcitabine activity. This stud
Autor:
Godefridus J. Peters, Kees Smid, Herbert Schott, Irene V. Bijnsdorp, Reto A. Schwendener, A.C. Laan, Iduna Fichtner, Sarah Schott
Publikováno v:
ChemInform. 39
Multidrugs have the potential to bypass resistance. We investigated the in vitro activity and resistance circumvention of the multidrug cytarabine-L-fluorodeoxyuridine (AraC-L-5FdU), linked via a glycerophospholipid linkage. Cytotoxicity was determin