Zobrazeno 1 - 10
of 112
pro vyhledávání: '"A.B. Keith"'
Publikováno v:
Glia. 44:1-12
Several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, are associated with immunocompetent microglia, leading to the suggestion that chronic glial-mediated inflammation contributes to the neurodegeneration seen in these
Autor:
David Neill, Geoffrey A. Taylor, Christopher Morris, David Allsop, D. Hughes, B. K. Rima, J.M. Candy, A.B. Keith, A. Leake, J.A. Edwardson
Publikováno v:
Journal of Neuroscience Research. 46:395-403
The environmental agent aluminium has been extensively investigated for a potential role in the aetiology of Alzheimer's disease. Despite many investigations there is at present no definite proof for any involvement. If aluminium is involved it is po
Publikováno v:
Neuroscience. 66:101-114
Two experiments examined the effects of cholinergic basal forebrain lesions by intraventricular and intrahippocampal infusions of the immunotoxin 192 IgG-saporin on recognition memory in an operant delayed-non-matching-to-position task in rats. Intra
Autor:
A.B. Keith, A. Sahgal
Publikováno v:
Pharmacology Biochemistry and Behavior. 45:995-1001
Rats were trained on a delayed nonmatching to position task, divided into four groups and given the following lesions: (a) SHAM (vehicle injection into nucleus basilis magnocellularis (NBM) and raphe nuclei (RN), (b) RN (5,7-dihydroxytryptamine lesio
Publikováno v:
Neuroscience Letters. 154:187-190
The role of oligodendrocyte-derived transferrin in the transport and regional accumulation of iron has been studied in myelin-deficient (md) rats, which lack functional oligodendrocytes and have an almost complete depletion of transferrin in the brai
Autor:
Christopher Morris, J.M. Candy, R. G. L. Pullen, C.A. Bloxham, Geoffrey A. Taylor, A. Gocht, J.A. Edwardson, Arthur E. Oakley, A.B. Keith
Publikováno v:
Journal of Inorganic Biochemistry. 47:257-265
The anatomical and cellular distribution of non-haem iron, ferritin, transferrin, and the transferrin receptor have been studied in postmortem human brain and these studies, together with data on the uptake and transport of labeled iron, by the rat b
Publikováno v:
Journal of Neurochemistry. 59:300-306
Brain uptake of iron-59 and iodine-125-labelled transferrin from blood in the adult rat has been investigated using graphical analysis to determine the blood-brain barrier permeability to these tracers in experiments that lasted between 5 min and 8 d
Publikováno v:
Behavioural Brain Research. 44:151-161
Rats with radiofrequency lesions of the fimbria/fornix, or neurotoxic lesions of the mammillary bodies or the anterior thalamic nuclei were tested on their ability to perform a delayed non-matching-to-position task that had been learnt before surgery
Publikováno v:
Journal of Psychopharmacology. 4:210-218
Groups of rats were trained on one of two variants of an operant memory task which allows strength of memory (accuracy), bias and response rates to be measured directly. In matching to position (MTP), one of two retractable response levers appeared a
Publikováno v:
Behavioural brain research. 61(1)
The cholinergic pedunculopontine tegmental nucleus, located in the brainstem, and part of the reticular formation, has traditionally been linked to motor function, sleep and arousal, but has recently been implicated in cognition. To investigate this