Zobrazeno 1 - 10
of 42
pro vyhledávání: '"A.B Khare"'
Snakebites, including poisonous ones, are common occurrence in tropical countries and are endemic during summer months.However, snake bite remains a neglected public health problem in resource limited countries like India. The snake venom may cause l
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b835fee53c0dfc755dd08944bb2361dd
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Publikováno v:
Nuclear Medicine and Biology. 27:749-755
The vesamicol analogue (+/-)-trans-2-Hydroxy-3-[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM), a potent ligand for the vesicular acetylcholine transporter (VAChT), was evaluated as a potential radiotracer for studying VAChT densi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e82b915e1616277ac4f8ef3ab7ef21
https://doi.org/10.1016/s0969-8051(00)00157-8
https://doi.org/10.1016/s0969-8051(00)00157-8
Publikováno v:
Nuclear Medicine and Biology. 26:609-617
Four isomeric N -(halophenyl)trozamicol analogues (6a–d) were synthesized and evaluated as potential vesicular acetylcholine transporter (VAChT) ligands. Of the four compounds, N -(3-bromophenyl)trozamicol (6b) and N -(3-iodophenyl)trozamicol (6d)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303a1e0a3570606f09abafdab901b594
https://doi.org/10.1016/s0969-8051(99)00013-x
https://doi.org/10.1016/s0969-8051(99)00013-x
Publikováno v:
European Journal of Pharmacology. 338:159-169
The vesamicol analogue, meta-[ 125 I ]iodobenzyltrozamicol [(+)-[ 125 I ]MIBT] was evaluated as a probe for the in vitro labeling of the vesicular acetylcholine transporter in primate brain. In the striatum, (+)-[ 125 I ]MIBT bound a single high-affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b011667f9e83dc67118df871ce571744
https://doi.org/10.1016/s0014-2999(97)81944-9
https://doi.org/10.1016/s0014-2999(97)81944-9
Publikováno v:
Neurobiology of Aging. 18:407-413
We have evaluated the vesamicol analogue meta-[125I]iodobenzyltrozamicol {(+)-[125I]MIBT} as a probe to assess cholinergic terminal integrity in the human temporal cortex. Saturation binding analysis, using 5-aminobenzovesamicol (ABV) to define nonsp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae3e38918b16a2682aedaf9570168e2
https://doi.org/10.1016/s0197-4580(97)00038-9
https://doi.org/10.1016/s0197-4580(97)00038-9
Publikováno v:
Nuclear Medicine and Biology. 22:437-444
Three conformationally restricted analogs of vesamicol, 1′-[1-(3-iodobenzyl)-4-hydroxypiperidin-3-yl]spirol[1H-indene-1,4′-piperidine] ( 5 ), 1′-[1-(3-iodobenzyl)-4-hydroxypiperidin-3-yl]-3,4-dihydrospiro[indene-1,4′-piperidine] ( 6 ) and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8466f46bfa1a2857d8ba70f98f253f95
https://doi.org/10.1016/0969-8051(94)00135-7
https://doi.org/10.1016/0969-8051(94)00135-7
Autor:
Surya K. Akella, Steven R. Childers, A.B Khare, Catherine Foulon, Stanley M. Parsons, Simon M. N. Efange, Robert H. Mach, Cynthia R. Smith
Publikováno v:
Biochemical Pharmacology. 49:791-797
The present study compares the affinities of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, 1) and selected analogues of the latter at the vesamicol receptor (VR) with the corresponding affinities at σ1 and σ2 binding sites. For this study, the par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1b305353048bec2199fb4d39abe2c99
https://doi.org/10.1016/0006-2952(94)00541-s
https://doi.org/10.1016/0006-2952(94)00541-s
Publikováno v:
Applied Radiation and Isotopes. 45:465-472
Current methods of radioligand synthesis for the vesamicol receptor either utilize bioactive unlabeled precursors and/or generate unlabelled bioactive by-products. The presence of these compounds in the radiotracer preparation increases the risk of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d38af5152f7923f95a112070ce0c31
https://doi.org/10.1016/0969-8043(94)90113-9
https://doi.org/10.1016/0969-8043(94)90113-9
Publikováno v:
Journal of Medicinal Chemistry. 36:1754-1760
Racemic (m-iodobenzyl)trozamicol (6, MIBT), a high-affinity vesamicol receptor ligand, was radiolabeled, resolved, and evaluated in rats. Following iv injection, (+)- and (-)-[125I]MIBT achieved initial brain levels of 0.57 and 0.92% dose/g of tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5182349ce0361422a27ee401c5ad98
https://doi.org/10.1021/jm00064a009
https://doi.org/10.1021/jm00064a009