Výsledky vyhledávání - "A.Allart Stoop"

High-density mutagenesis by combined DNA shuffling and phage display to assign essential amino acid residues in protein-protein interactions: application to study structure-function of plasminogen activation inhibitor 1 (PAI-I)

Autor: Ignace Lasters, Laurent Stephane Anne Therese Jespers, Hans Pannekoek, A.Allart Stoop, Eric Eldering

Publikováno v: Journal of molecular biology, 301(5), 1135-1147. Academic Press Inc.

The identification of specific amino acid residues involved in protein-protein interaction is fundamental to understanding structure-function relationships. Supported by mathematical calculations, we designed a high-density mutagenesis procedure for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e363a399f3f0cb70955131c5edde27
https://doi.org/10.1006/jmbi.2000.4035

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The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop 1 1Edited by A. R. Fersht

Autor: Wolfram Bode, Andreas Eichinger, Anton J.G. Horrevoets, Rob J. Dekker, Hans Pannekoek, A.Allart Stoop

Publikováno v: Journal of Molecular Biology. 293:613-627

Substitution of the native variable region-1 (VR1/37-loop) of thrombin by the corresponding VR1 of tissue-type plasminogen activator (thrombin-VR1tPA) increases the rate of inhibition by plasminogen activator inhibitor type 1 (PAI-1) by three orders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16b1131b4fb1c0b79454743c9ee8d98e
https://doi.org/10.1006/jmbi.1999.3178

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Molecular Advances in Plasminogen Activator Inhibitor 1 Interaction with Thrombin and Tissue-Type Plasminogen Activator

Autor: A.Allart Stoop, Anton J. G. Horrevoets, M van Meijer, H. Pannekoek

Publikováno v: Trends in cardiovascular medicine, 7(2), 47-51. Elsevier Inc.

Plasminogen activator inhibitor 1 (PAI-1) is a glycoprotein that controls the activity of the key enzymes of the fibrinolytic system, the serine proteases tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a198529b3b1d63ebe896cf35ed85149
https://doi.org/10.1016/s1050-1738(96)00141-7

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Colocalization of thrombin, PAI-1, and vitronectin in the atherosclerotic vessel wall: A potential regulatory mechanism of thrombin activity by PAI-1/vitronectin complexes

Autor: A.Allart Stoop, Hans Pannekoek, Florea Lupu

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 20(4), 1143-1149. Lippincott Williams and Wilkins

Abstract —The serine protease thrombin is a mitogen for vascular smooth muscle cells. To that end, thrombin cleaves the surface-exposed, protease-activated receptor type 1 (PAR-1), resulting in signal transduction and ultimately, proliferation of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d62157c763c72e8f23bf3ffd02b10b
https://pubmed.ncbi.nlm.nih.gov/10764685

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