Zobrazeno 1 - 10
of 29
pro vyhledávání: '"A.A.J. van Iersel"'
Autor:
A.A.J. van Iersel, Bas J. Blaauboer, C.W.M. van Holsteijn, Jan Noordhoek, Sing Hiem Yap, W.C. Mennes
Publikováno v:
Human & Experimental Toxicology. 13:415-421
1 Bromobenzene-evoked hepatotoxicity resulting from cytochrome P450-mediated epoxidation has been studied extensively in rodents in vivo and in rodent hepatocytes. In this paper we present data concerning the formation of bromphenols, glutathione (GS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51879014e675423a79046ab65035533
https://doi.org/10.1177/096032719401300609
https://doi.org/10.1177/096032719401300609
Autor:
Heleen M. Wortelboer, H.E. Falke, C.A. de Kruif, Jan Noordhoek, Bas J. Blaauboer, A.A.J. van Iersel, P.J. van Bladeren
Publikováno v:
Food and Chemical Toxicology. 30:17-27
Male Wistar rats were given semi-synthetic diets supplemented with 0, 2.5, 5 and 20% cooked Brussels sprouts for 2, 7, 14 or 28 days. The effects on several cytochrome P -450 enzymes and phase II enzymes (glutathione S -transferase (GST), glucuronyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24e34a5f1a0ed68fc1abbb603b0e063
https://doi.org/10.1016/0278-6915(92)90132-5
https://doi.org/10.1016/0278-6915(92)90132-5
Autor:
Heleen M. Wortelboer, C.A. de Kruif, H.E. Falke, Bas J. Blaauboer, A.A.J. van Iersel, Jan Noordhoek
Publikováno v:
Biochemical Pharmacology. 42:381-390
The metabolic profile of seven subfamilies of cytochrome P450 (P450IA, IIA, IIB, IIC, IIE, IIIA, IVA) was studied in rat liver (in vivo) and in primary hepatocyte cultures (in vitro) after treatment with various inducers. The dealkylation of 7-ethoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3900d691b01546f35447de039169aa18
https://doi.org/10.1016/0006-2952(91)90726-l
https://doi.org/10.1016/0006-2952(91)90726-l
Publikováno v:
Aquatic Toxicology. 16:53-72
Toxicity studies were carried out on the Japanese medaka (Oryzias latipes) with bis(tri-n-butyltin)oxide (TBTO) and di-n-butyltindichloride (DBTC), with emphasis on histopathological effects. Freshly fertilized eggs were exposed for 1 and 3 months to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeeda33e1f2558df45baaebf82deeb3f
https://doi.org/10.1016/0166-445x(90)90077-3
https://doi.org/10.1016/0166-445x(90)90077-3
Autor:
Jan Noordhoek, H.E. Falke, Bas J. Blaauboer, C.A. de Kruif, Heleen M. Wortelboer, A.A.J. van Iersel
Publikováno v:
Biochemical pharmacology. 43(7)
The effects of three acid condensation products of indole-3-carbinol (I3C), i.e. 3,3'-diindolylmethane (DIM), 5,6,11,12,17,18-hexahydrocyclonona[1,2-b:4,5-b':7,8-b"]tri-indole (CTI) and 2,3-bis[3-indolylmethyl]indole (BII), on cytochrome P450 and pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7a1b73296288d831af221693799134
https://pubmed.ncbi.nlm.nih.gov/1567468
https://pubmed.ncbi.nlm.nih.gov/1567468
Autor:
Jan Noordhoek, C.A. de Kruif, H.E. Falke, A.A.J. van Iersel, Bas J. Blaauboer, Heleen M. Wortelboer
Publikováno v:
Biochemical pharmacology. 40(11)
Changes in the isoenzyme pattern of cytochrome P450 during culture were investigated in primary cultures of rat hepatocytes, measuring specific enzyme activities in microsomes prepared from cultured cells as well as in intact monolayers. Assays of 7-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f241396b64a5c9e1726451ea288862
https://pubmed.ncbi.nlm.nih.gov/2268371
https://pubmed.ncbi.nlm.nih.gov/2268371
Autor:
A.A.J. van Iersel, J. F. van Pelt, W.C. Mennes, F.N.A.M. van Pelt, R. Bleumink, Sing Hiem Yap, Bas J. Blaauboer, B. P. Schmid, A. Timmerman, C. W. M. Vdan Holsteijn
Publikováno v:
Biochemical pharmacology. 40(3)
The peroxisome-proliferating effects of clofibric acid and beclobric acid were studied in primary cultures of hepatocytes derived from rat, monkey (Macaca fascicularis) and human liver. Determination of peroxisomal fatty acid beta-oxidation and morph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4273907f0ebd45043d5f20c47240b1e9
https://pubmed.ncbi.nlm.nih.gov/2383284
https://pubmed.ncbi.nlm.nih.gov/2383284
Publikováno v:
Toxicology and Applied Pharmacology. 81:274-286
In 2-week feeding studies, a series of trialkyltin chlorides and triphenyltin chloride were fed to male weanling rats at different dietary concentrations to evaluate their toxic effects, especially on the brains and the lymphoid organs, thymus and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ebb83ddb7d49bf8d251aa3316362bd
https://doi.org/10.1016/0041-008x(85)90164-4
https://doi.org/10.1016/0041-008x(85)90164-4
Publikováno v:
Toxicology. 39:71-83
To further investigate the immunotoxic effects of tri-n-propyltin chloride (TPTC), tri-n-butyltin chloride (TBTC) and triphenyltin chloride (TPhTC) several cytotoxicity tests with a series of trialkyltin chlorides and TPhTC were carried out, using is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f35115aca5565891c3c10c8e47459f
https://doi.org/10.1016/0300-483x(86)90160-5
https://doi.org/10.1016/0300-483x(86)90160-5
Autor:
A.A.J. van Iersel, Bas J. Blaauboer
Publikováno v:
Comparative biochemistry and physiology. B, Comparative biochemistry. 81(4)
1. 1. The assay for NADH-ferrihemoglobin reductase (NADH-FR) was optimized for avian blood samples. 2. 2. In this assay the pH optimum for Japanese quail red cell NADH-FR was 5.5, which was close to the enzyme's pI. 3. 3. Enzyme kinetic parameters we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7420133e18ea321247c16b9a58488c3
https://pubmed.ncbi.nlm.nih.gov/4042621
https://pubmed.ncbi.nlm.nih.gov/4042621