Zobrazeno 1 - 10 of 455 pro vyhledávání: '"A.A. Spasov"'
1
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3
EFFECT OF ADJUVANT PREPARATIONS ON THE EXPRESSION OF ANALGETIC ACTIVITY OF MORPHIN IN SOMATOGENIC PAIN
Autor: Yu.V. Semenova, N.V. Eliseeva, A.A. Spasov
Publikováno v: Journal of Volgograd State Medical University. 17:141-145
Combination of traditional opioid with coanalgesics is recommended to reduce the dose of analgesics and the side effects as well as the relief of different pain severity. In this study was evaluated the effectiveness of different adjuvant drugs: halo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::758b6fc2d8af4b00bcb099d3bc540153
https://doi.org/10.19163/1994-9480-2020-4(76)-141-145
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4
CUMULATIVE PROPERTIES OF THE NEW ANTI-MIGENOUS COMPOUND IN THE TABLET MEDICAL FORM
Autor: A.Yu. Getmamenko, L.I. Bugaeva, A.A. Spasov, V. I. Kornilov, D.S. Yakovlev, V. V. Bagmetova
Publikováno v: Journal of Volgograd State Medical University. 17:46-49
Cumulative properties of 2-metoxifenil-imidazobenzimidazole derivative (RU-31) in tablet medical form (8 mg) were studied for development of new drug for migraine treatment. Four-week experiments were carried out on white rats of both sex, with intra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::deed457f0759a088a5fc374582014740
https://doi.org/10.19163/1994-9480-2020-4(76)-46-49
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5
THE CONSENSUS PREDICTION IN SILICO OF PHARMACOKINETIC PREFERENCE OF MULTI-TARGET RAGE INHIBITORS
Autor: D.A. Babkov, A.V. Golubeva, M.A. Perfiliev, P. M. Vasiliev, A. N. Kochetkov, A. R. Koroleva, D.O. Martynova, A.A. Spasov, R.A. Litvinov
Publikováno v: Journal of Volgograd State Medical University. 17:100-104
Using a neural network model based on docking, among 87 new synthesized substances of ten structurally diverse chemical classes, ten compounds with predicted high RAGE-inhibitory activity were found, and for these by means of QikProp, PASS programs a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::279d45371d43312d7a733c41ffd9f64e
https://doi.org/10.19163/1994-9480-2020-2(74)-100-104
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6
ANTITHROMBOTIC EFFECT OF A COMPOUND RU-1144 ON THE MODEL OF SYSTEMIC ARTERIAL THROMBOSIS
Autor: N. G. Panshin, O.N. Zhukovskaya, A.F. Kucheryavenko, A. V. Smirnov, K. A. Gaidukova, A.A. Spasov, V. S. Sirotenko
Publikováno v: Journal of Volgograd State Medical University. 17:111-115
In this study, the antithrombotic activity of a new chemical compound of a benzimidazole derivative, which has a shielded phenolic substituent in its structure, under the laboratory code RU-1144 was studied, which exhibits high antiplatelet and antio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::049fe668d5958da5bec1b6beccbc1593
https://doi.org/10.19163/1994-9480-2020-1(73)-111-115
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8
Akademický článek
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9
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10
THE CONSENSUS ESTIMATION IN SILICO OF ACUTE TOXICITY OF MULTI-TARGET RAGE INHIBITORS
Autor: R.A. Litvinov, A.A. Spasov, D.A. Babkov, A. N. Kochetkov, Pavel M. Vassiliev
Publikováno v: Journal of Volgograd State Medical University. 17:31-33
The virtual screening of RAGE inhibitory activity for 87 novel synthesized compounds of 10 structurally different chemical classes using neural network model on base of docking was carried out. According prediction, 26 potential active structures wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4bebc450b6cc6a1afaf8a84a9f7d4bb
https://doi.org/10.19163/1994-9480-2020-1(73)-31-33
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