Zobrazeno 1 - 10
of 71
pro vyhledávání: '"A.A. Ritchie"'
Autor:
Aranzazu Chamorro-Jorganes, Iñigo Ruiz-Polo, Dhananjie Chandrasekera, Graciela B. Sala-Newby, Nicholas Beazley-Long, A.A. Ritchie, Andrew V. Benest, Walid Sweaad, Rajesh Katare, Marie Besnier, Costanza Emanueli, Maryam Anwar
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 41(6)
Objective: Postnatal angiogenesis is critical in vascular homeostasis and repair. m 6 A (N6-methyladenosine) RNA methylation is emerging as a new layer for fine-tuning gene expression. Although the contribution of the m 6 A-catalyzing enzyme, METTL3
Autor:
David Onion, Beth Coyle, Franziska Linke, Cara Valente, Hanna Cameron, Aishah Nasir, A.A. Ritchie, Marina Ryzhova, Anbarasu Lourdusamy, Niovi Nicolaou, Alice Cardall, Andrey Korshunov, Ramadhan T. Othman, Ian D. Kerr, Anna M. Grabowska, Stefan M. Pfister
Publikováno v:
Neuro-oncology Advances
Background Therapeutic intervention in metastatic medulloblastoma is dependent on elucidating the underlying metastatic mechanism. We investigated whether an epithelial–mesenchymal transition (EMT)-like pathway could drive medulloblastoma metastasi
Autor:
Gareth J. Veal, Toby W.A. Gould, A.A. Ritchie, Stuart Smith, Henry Brem, Riccardo Serra, Kevin M. Shakesheff, Betty Tyler, Ruman Rahman, Philip Berry, Noah Gorelick, Nicolas Skuli, John Choi, Richard Grundy, Annette Otto, Jonathan Rowlinson, Maria de los Angeles Estevez-Cebrero
Publikováno v:
Clinical Cancer Research. 25:5094-5106
Purpose: High-grade glioma (HGG) treatment is limited by the inability of otherwise potentially efficacious drugs to penetrate the blood–brain barrier. We evaluate the unique intracavity delivery mode and translational potential of a blend of poly(
Autor:
Ewan Kyle, Pamela Collier, Zoë S. Walters, Anna M. Grabowska, Antigoni Manousopoulou, Benjamin P. Sharpe, Andrew Cowie, Spiros D. Garbis, Fereshteh Izadi, Robert C. Walker, Simon L. Parsons, A.A. Ritchie, Philip A. Clarke, John H. Saunders, Annette Hayden, Timothy J. Underwood, Jack Harrington, Stella P. Breininger, Matthew J. J. Rose-Zerilli
Publikováno v:
SSRN Electronic Journal.
The chemotherapy resistance of esophageal adenocarcinomas (EAC) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that by targeting the tumor-promoting functions of the predominant TME cell type, c
Autor:
Morgan R. Alexander, Anna M. Grabowska, Philip A. Clarke, Thomas M. Bennett, Vincenzo Taresco, Cameron Alexander, A.A. Ritchie, Amanda K. Pearce, Robert Cavanagh, Akosua B. Anane-Adjei, Patrícia F. Monteiro
© 2020 Wiley-VCH GmbH The size, shape, and underlying chemistries of drug delivery particles are key parameters which govern their ultimate performance in vivo. Responsive particles are desirable for triggered drug delivery, achievable through archi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf5638c908c0f53eaac58c7240d6cb0
Autor:
Haimei Chen, Peter J. Sadler, Duncan I. Jodrell, A.A. Ritchie, M. Muir, Jeffrey Cummings, Morris Robert Edward, R E Aird
Publikováno v:
British Journal of Cancer
Ruthenium complexes offer the potential of reduced toxicity, a novel mechanism of action, non-cross resistance and a different spectrum of activity compared to platinum containing compounds. Thirteen novel ruthenium(II) organometallic arene complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b256244e60ea78b061bef423440ddcf
Autor:
Philip A. Clarke, Michael W. Fay, Jatin Mistry, Phoebe McCrorie, A.A. Ritchie, Ian A. Ward, Stuart Smith, Vincenzo Taresco, Maria Marlow, Ruman Rahman, Tatiana Lovato
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 157
Glioblastoma is a malignant brain tumour with a median survival of 14.6 months from diagnosis. Despite maximal surgical resection and concurrent chemoradiotherapy, reoccurrence is inevitable. To try combating the disease at a stage of low residual tu
Autor:
Spiros D. Garbis, Jack Harrington, A.A. Ritchie, John H. Saunders, Simon L. Parsons, Andrew Cowie, Annette Hayden, Benjamin P. Sharpe, Robert C. Walker, Pamela Collier, Matthew J. J. Rose-Zerilli, Fereshteh Izadi, Timothy J. Underwood, Ewan Kyle, Antigoni Manousopoulou, Anna M. Grabowska, Philip A. Clarke
Background and aimsEsophageal adenocarcinoma (EAC) is chemoresistant in the majority of cases. The tumor-promoting biology of cancer associated fibroblasts (CAF) make them a target for novel therapies. Phosphodiesterase type 5 inhibitors (PDE5i) have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2abc0610d429fcaa5613b5bae769748
https://doi.org/10.1101/2020.04.21.052647
https://doi.org/10.1101/2020.04.21.052647
Autor:
Anbarasu Lourdusamy, Katie Wood, Stuart Smith, A.A. Ritchie, David Onion, Philip A. Clarke, Ruman Rahman, Richard Grundy, Jonathan Rowlinson, Mohammed Diksin, Maria de los Angeles Estevez-Cebrero
Publikováno v:
Neuro-oncology Advances
Background Glioblastoma (GBM) is a highly aggressive brain tumor with rapid subclonal diversification, harboring molecular abnormalities that vary temporospatially, a contributor to therapy resistance. Fluorescence-guided neurosurgical resection util
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