Zobrazeno 1 - 10
of 42
pro vyhledávání: '"A.A. Dunk"'
Autor:
Chia-Ming Chu, J. Monjardino, C. Greenfield, M. J. F. Fowler, Eng-Kiong Yeoh, Peter Karayiannis, B. M. Wankya, Anna S.F. Lok, Ching-Lung Lai, A.A. Dunk, H.C. Thomas
Publikováno v:
Journal of Hepatology. 2:218-229
Summary Hundred and ten liver biopsy specimens from various parts of the world were examined for episomal and integrated HBV-DNA sequences. In 54 patients with HBsAg chronic liver disease episomal HBV-DNA was found in 83% of HBeAg-positive patients,
Autor:
Anna S.F. Lok, Sheila Sherlock, A.A. Dunk, Peter Karayiannis, Howard C. Thomas, David M. Novick
Publikováno v:
Hepatology. 5:1132-1138
A previous randomized controlled study has shown a 30% rate of HBe antigen/antibody seroconversion within 1 year of a month course of adenine arabinoside-5'-monophosphate; no seroconversion occurred in the control group. In this study of patients der
Autor:
John A. O. Besson, John Robertson Crawford, H. Deans, P.W. Brunt, N.A.G. Mowat, T.S. Sinclair, J.W. Moore, G. De Lacey, A.A. Dunk
Publikováno v:
Journal of Hepatology. 9:319-325
By means of psychometric testing, we have determined the frequency of latent hepatic encephalopathy in a group of 19 cirrhotics with no clinical evidence of encephalopathy. Magnetic resonance imaging (MRI) of the brain was performed in order to deter
Autor:
S.C. Scott, Iain M. Murray-Lyon, W M Melia, H.C. Thomas, P.J. Johnson, A.A. Dunk, Roger Williams, Anna S.F. Lok
Publikováno v:
Journal of Hepatology. 1:395-404
Summary Thirty-five patients with hepatocellular carcinoma (HCC) have been treated with the Anthracenedione derivative, Mitozantrone. One complete and 5 partial responses were seen in 22 evaluable patients and in a further 4 patients tumour size rema
Autor:
M. J. F. Fowler, Sheila Sherlock, J. Monjardino, H. Spiliadis, Howard C. Thomas, P. J. Scheuer, A.A. Dunk
Publikováno v:
International Journal of Cancer. 41:17-23
We have examined the clinical, prognostic, aetiological and pathological features of 41 consecutive British patients with hepatocellular carcinoma (HCC). Presenting symptoms were often vague, and patients were generally in poor condition at diagnosis
Publikováno v:
Journal of Hepatology. 4:52-61
A monoclonal antibody, designated K-PLC1, has been produced to a tumour-associated antigen on the cell membrane of the PLC/PRF/5 cell line. Using an indirect immunofluorescence technique this antibody produced membrane staining of three hepatocellula
Autor:
Sheila Sherlock, Robert Dick, Andrew K. Burroughs, William J. Jenkins, Steven Mackie, Tom O. K. Osuafor, Robert P. Walt, A.A. Dunk
Publikováno v:
New England Journal of Medicine. 309:1539-1542
We conducted a prospective randomized trial of propranolol for the prevention of recurrent variceal bleeding in 48 patients with cirrhosis of the liver. During a follow-up period of up to 21 months, 12 of 26 patients in the propranolol group and 11 o
Publikováno v:
Journal of Hepatology. 2:419-429
We have examined the growth inhibitory effects of human lymphoblastoid interferon (IFN) on the human hepatocellular carcinoma (HCC) cell line PLC/PRF/5. In vitro, PLC/PRF/5 cells were sensitive to the antiproliferative effects of IFN, growth inhibiti
Publikováno v:
Scandinavian journal of gastroenterology. 22(10)
We have measured natural killer (NK) cell activity in patients with hepatocellular carcinoma (HCC) and have examined the effects of in vitro and in vivo administration of alpha-interferon (IFN) on NK cell activity. The NK cell cytotoxicity of HCC pat
Publikováno v:
Alimentary pharmacologytherapeutics. 1(4)
SUMMARY Human lymphoblastoid interferon, in an initial dose of 2.5 MU m−2 weekly i.m., was given with mitozantrone 12 mg m−2 i.v. every 3 weeks to 15 patients with hepatocellular carcinoma. The survival curve for these patients was worse than tha