Zobrazeno 1 - 10
of 42
pro vyhledávání: '"A.-N. Tony Kong"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783(10):1847-1856
Nrf2 is the key transcription factor regulating the antioxidant response. When exposed to oxidative stress, Nrf2 translocates to cell nucleus and forms heterodimer with small Maf proteins (sMaf). Nrf2/sMaf heterodimer binds specifically to a cis-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab0feac079244ef50000be3a36faf98
Autor:
Wenge Li, Vidya Hebbar, Wen Lin, Jiahuai Han, Michael A. Gallo, Changjiang Xu, Young Sam Keum, Guoxiang Shen, A.-N. Tony Kong, Sujit Nair
Publikováno v:
Journal of Biological Chemistry. 279:23052-23060
Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II detoxifying enzymes as well as anti-oxidative enzymes. In this study, we investigated the transactivation potential of different Nrf2 transactivation domain region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ee5d1523d74fc958890a21958654e7
https://doi.org/10.1074/jbc.m401368200
https://doi.org/10.1074/jbc.m401368200
Publikováno v:
Life Sciences. 72:2243-2253
Cell-based models have been used extensively in screening novel bioactive chemical entities. In this study, seven well-established mammalian cell lines, which have different origins, were utilized to compare their responses to the treatments of three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed62ea4e60b8de2fa96ff945e0fdfc99
https://doi.org/10.1016/s0024-3205(03)00101-2
https://doi.org/10.1016/s0024-3205(03)00101-2
Publikováno v:
Pharmaceutical Research. 20:1351-1356
Purpose. Phenethyl isothiocyanate (PEITC) has been of great interest as a promising cancer chemopreventive agent. To better understand its chemopreventive activity, we examined the effect of PEITC on the antioxidant responsive element (ARE), which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21c1eea82a3d93bc4903ce2391819249
https://doi.org/10.1023/a:1025737622815
https://doi.org/10.1023/a:1025737622815
Autor:
Wenge Li, Songtao Yu, M. Sambasiva Rao, Parimal Misra, Edward D. Owuor, Kirstin Meyer, A.-N. Tony Kong, Chao Qi, Yi Jun Zhu, Janardan K. Reddy
Publikováno v:
Journal of Biological Chemistry. 277:48745-48754
Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) is an important coactivator for PPARgamma and other transcription factors. PBP is an integral component of a multiprotein thyroid hormone receptor-associated protein (TRAP)/vitam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152baedecd7973dfe3f432daa47b357e
https://doi.org/10.1074/jbc.m208829200
https://doi.org/10.1074/jbc.m208829200
Autor:
Khew-Voon Chin, A.-N. Tony Kong
Publikováno v:
Pharmaceutical Research. 19:1773-1778
Many drugs or xenobiotics can induce specific or nonspecific cellular signal transduction events that activate various physiologic and pharmacologic responses including homeostasis, proliferation, differentiation, apoptosis, and necrosis. To minimize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85da4c6b0481654c18a7a86967d23e81
https://doi.org/10.1023/a:1021425004264
https://doi.org/10.1023/a:1021425004264
Autor:
Jie Wu, Wei Lei, Michael J. Weber, Rong Yu, Sandhya Mandlekar, A.-N. Tony Kong, Channing J. Der
Publikováno v:
Journal of Biological Chemistry. 274:27545-27552
Mitogen-activated protein kinase (MAPK) cascades are activated by diverse extracellular signals and participate in the regulation of an array of cellular programs. In this study, we investigated the roles of MAPKs in the induction of phase II detoxif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b678e06184bf91b7006ccdada64530
https://doi.org/10.1074/jbc.274.39.27545
https://doi.org/10.1074/jbc.274.39.27545
Publikováno v:
Journal of Biological Chemistry. 272:28962-28970
Phenolic antioxidant butylated hydroxyanisole (BHA) is a commonly used food preservative with broad biological activities, including protection against acute toxicity of chemicals, modulation of macromolecule synthesis and immune response, induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8919e875bf0b49a590270914f39ee82d
https://doi.org/10.1074/jbc.272.46.28962
https://doi.org/10.1074/jbc.272.46.28962
Publikováno v:
The Journal of biological chemistry. 281(37)
NF-E2-related factor 2 (Nrf2) is the key transcription factor regulating the antioxidant response. Previous studies identified a nuclear localization signal (NLS) in the basic region and a nuclear exporting signal (NES) in the leucine zipper domain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d11c7b7bab6d8ed94f5d243328daa6b
https://pubmed.ncbi.nlm.nih.gov/16790425
https://pubmed.ncbi.nlm.nih.gov/16790425
Publikováno v:
The Journal of biological chemistry. 280(31)
Basic leucine zipper (bZIP) protein Nrf2 is a key transcription factor mediating the antioxidant response. Under homeostatic conditions Nrf2 is anchored to cysteine-rich Keap1 and sequestered in the cytoplasm. When challenged with oxidative stress, K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87abab7887de6be03b2abeb271eabfda
https://pubmed.ncbi.nlm.nih.gov/15917227
https://pubmed.ncbi.nlm.nih.gov/15917227