Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432

Autor: Philip G. Humphreys, Niall A. Anderson, Paul Bamborough, Andrew Baxter, Chun-wa Chung, Rosa Cookson, Peter D. Craggs, Toryn Dalton, Julie C. L. Fournier, Laurie J. Gordon, Heather F. Gray, Matthew W. Gray, Richard Gregory, David J. Hirst, Craig Jamieson, Katherine L. Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K. Patel, Christopher Patten, Darren L. Poole, Rab K. Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A. J. Stafford, Rishi R. Shah, Daniel Tape, Natalie H. Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D. Wall, Natalie Wellaway, Gemma White

Publikováno v: Journal of Medicinal Chemistry. 65:15174-15207

The bromodomain and extra terminal (BET) family of proteins are an integral part of human epigenome regulation, the dysregulation of which is implicated in multiple oncology and inflammatory diseases. Disrupting the BET family bromodomain acetyl-lysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c403b556d0cdc2a89bb75345904c1
https://doi.org/10.1021/acs.jmedchem.2c01102

EFFICACITE ET TOLERANCE DES ANTIBIOTIQUES DANS LA GRIPPE NON COMPLIQUEE, LA BRONCHITE AIGUE, L'OTITE SEROMUQUEUSE ET LA RHINOPHARYNGITE AIGUE

Autor: L DEVILLERS, H TEYSSIER, S STEENKISTE, L FOURNIER, A HAZARD, M FRANCOIS

Publikováno v: EXERCER. 33:77-85

Contexte. Dans le cadre de la lutte contre la surmédicalisation, une liste de 5 procédures de soins fréquemment prescrites en médecine générale, malgré une balance bénéfice-risque défavorable (« liste des 5 »), a été formalisée en Fran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5772d0f0470a3c77dc4752e847b90919
https://doi.org/10.56746/exercer.2022.180.77

Feasibility and Implementation of a Literature Information Management System for Human Papillomavirus in Head and Neck Cancers with Imaging

Autor: Dee H. Wu, Chance L. Matthiesen, Anthony M. Alleman, Aaron L. Fournier, Tyler C. Gunter

Publikováno v: Cancer Informatics, Vol 2014, Iss Suppl. 1, Pp 49-57 (2014)

Externí odkaz: https://doaj.org/article/cccbb73f1c114fcaa8abe3f3038d33be

Une péritonite encapsulante

Autor: Albertine Aouba, Thierry Lobbedez, Antoine Hankard, L. Fournier, Alexandra Audemard-Verger

Publikováno v: La Revue de Médecine Interne. 41:130-133

Resume Introduction La peritonite encapsulante est une affection fibrosante chronique rare mais severe relative a la constitution d’une sclerose peritoneale partielle ou totale retractile engainant le tube digestif. De rares formes idiopathiques on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fb97ac45d65d4312058d3c50d4daa08
https://doi.org/10.1016/j.revmed.2019.09.006

Dolutegravir Monotherapy as Maintenance Strategy: A Meta-Analysis of Individual Participant Data From Randomized Controlled Trials

Autor: Anna L Fournier, Laurent Hocqueloux, Dominique L Braun, Karin J Metzner, Roger D Kouyos, François Raffi, Anaïs R Briant, Esteban Martinez, Elisa De Lazzari, Eugenia Negredo, Bart Rijnders, Casper Rokx, Huldrych F Günthard, Jean-Jacques Parienti

Publikováno v: Open Forum Infectious Diseases
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Open Forum Infectious Diseases, 9(6):ofac107. Oxford University Press

Background Dolutegravir monotherapy (DTG-m) results in virological failure (VF) in some people with human immunodeficiency virus (PWH). We sought to identify the independent factors associated with the risk of VF and to explore the effect size hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990eb1e7ff46d2189e39cc7d0d608952
https://doi.org/10.1093/ofid/ofac107