Zobrazeno 1 - 10
of 21
pro vyhledávání: '"A.-K. Struss"'
Autor:
Matthew Lardy, Kim D. Janda, Joseph T. Barbieri, Anjali K. Struss, Jenny M. Lively, Peter Šilhár, Sacha Javor, Mark S. Hixon, Charles B. Shoemaker
Publikováno v:
ACS Medicinal Chemistry Letters. 4:283-287
Botulinum neurotoxins (BoNTs) are among the most deadly poisons known though ironically, they also are of great therapeutic utility. A number of research programs have been initiated to discover small molecule inhibitors of BoNTs metalloprotease acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7aa616ae5de3c2433d45410d4f8a5e
https://doi.org/10.1021/ml300428s
https://doi.org/10.1021/ml300428s
Autor:
Kim D. Janda, Berthold F. Matzanke, Nicole Davis, Carl J. Carrano, Anjali K. Struss, Colin A. Lowery, Tobias Hahn, Ariel Romano, Lars H. Böttger
Publikováno v:
Journal of Inorganic Biochemistry. 107:96-103
Bacteria use small diffusible molecules to exchange information in a process called quorum sensing (QS). An important class of quorum sensing molecules used by Gram-negative bacteria is the family of N-acylhomoserine lactones (HSL). It was recently d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a102468757a0ddfc4f7fd205820d8107
https://doi.org/10.1016/j.jinorgbio.2011.10.009
https://doi.org/10.1016/j.jinorgbio.2011.10.009
Autor:
Kim D. Janda, Amanda L. Garner, Colin A. Lowery, Junguk Park, Jing Yu, Vladimir V. Kravchenko, Anjali K. Struss, Alexander V. Mayorov, Jie Zhu, Sook Kyung Kim, Gunnar F. Kaufmann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2702-2705
Alkynyl- and azido-tagged 3-oxo-C(12)-acylhomoserine lactone probes have been synthesized to examine their potential utility as probes for discovering the mammalian protein target of the Pseudomonas aeruginosa autoinducer, 3-oxo-C(12)-acylhomoserine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de90bf37be90600f857fa67383cb71d
https://doi.org/10.1016/j.bmcl.2010.11.122
https://doi.org/10.1016/j.bmcl.2010.11.122
Autor:
Eckart Meese, Angela Munnia, W-I Steudel, Ulrike Fischer, Hiroko Ohgaki, Wolfgang Feiden, Jochem König, Bernd F. M. Romeike, Wolfgang Nastainczyk, A-K Struss
Publikováno v:
Oncogene. 20:4107-4114
Glioblastoma multiforme (GBM), a malignant astrocytic tumour, represents the most frequent tumour of the human brain. Nevertheless, its molecular pathology is not well understood. We utilized the immune system, which contributes to cancer protection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9485ee2d47eec81baa220a7eb91cb1
https://doi.org/10.1038/sj.onc.1204552
https://doi.org/10.1038/sj.onc.1204552
Autor:
Kim D. Janda, Jie Zhu, Brent D. Feske, Anjali K. Struss, Richard Watkins, Sook Kyung Kim, Gunnar F. Kaufmann, Amanda L. Garner
Publikováno v:
PLoS ONE
The authors request the retraction of the manuscript, “Stereochemical Insignificance Discovered in Acinetobacter baumannii Quorum Sensing,” as the main conclusion reporting a case of stereochemical insignificance in A. baumannii is not supported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da087d09ffda81c2a43bef00d5d5a307
https://doi.org/10.1371/annotation/1345f9b0-016e-4123-9e72-6ccc4fa17ba2
https://doi.org/10.1371/annotation/1345f9b0-016e-4123-9e72-6ccc4fa17ba2
Autor:
Gunnar F. Kaufmann, Ashlee A. K. Nunes, Judith R. Denery, Kim D. Janda, Anjali K. Struss, Colin A. Lowery, Jill Waalen, Douglas Conrad, Prasanna Pullanikat
Publikováno v:
Analytical chemistry. 85(6)
The opportunistic bacterial pathogen Pseudomonas aeruginosa causes chronic lung infections in cystic fibrosis (CF) patients. Importantly, virulence factor expression and biofilm formation in P. aeruginosa is coordinated by quorum sensing (QS) and one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e6169e7f3394aa18ae5d98811d4571
https://pubmed.ncbi.nlm.nih.gov/23391272
https://pubmed.ncbi.nlm.nih.gov/23391272
Autor:
Kim D. Janda, Amanda L. Garner, Seth M. Cohen, Amira Y. Moreno, Anjali K. Struss, Jessica L. Fullagar, Arpita Agrawal
Bacterial resistance coupled to our current arsenal of antibiotics presents us with a growing threat to public health, thus warranting the exploration of alternative antibacterial strategies. In particular, the targeting of virulence factors has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4259a795d2fa1584988cb967c6cef9
https://europepmc.org/articles/PMC3501683/
https://europepmc.org/articles/PMC3501683/
Autor:
Anjali K. Struss, Amanda L. Garner, Brent D. Feske, Gunnar F. Kaufmann, Kim D. Janda, Richard Watkins, Sook Kyung Kim, Jie Zhu
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37102 (2012)
PLoS ONE
PLoS ONE
Stereochemistry is a key aspect of molecular recognition for biological systems. As such, receptors and enzymes are often highly stereospecific, only recognizing one stereoisomer of a ligand. Recently, the quorum sensing signaling molecules used by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca720802d108e9898b26b66e97cff4a
http://europepmc.org/articles/PMC3358330?pdf=render
http://europepmc.org/articles/PMC3358330?pdf=render
Autor:
Junguk Park, Kim D. Janda, Colin A. Lowery, Anjali K. Struss, Gunnar F. Kaufmann, Daisuke Sawada, Joseph S. Zakhari, Amanda L. Garner
Multivalency is a common principle in the recognition of cellular receptors, and multivalent agonists and antagonists have played a major role in understanding mammalian cell receptor biology. The study of bacterial cell receptors using similar appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd120c8647f0e824e6a24570b0d53f5
https://europepmc.org/articles/PMC3203215/
https://europepmc.org/articles/PMC3203215/
Autor:
Anjali K. Struss, Colin A. Lowery, Isao Kinoyama, Matthew Lardy, Kim D. Janda, Joseph S. Zakhari, Prasanna Pullanikat
Publikováno v:
Journal of the American Chemical Society. 133(11)
The triphenyl amide/ester 12 was originally reported to be a potent mimic of the natural 3-oxo-dodecanoyl homoserine lactone quorum sensing molecule in Pseudomonas aeruginosa. However, explicit synthesis/chemical characterization was lacking, and a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9016e6393182b7936158254a874d52d2
https://pubmed.ncbi.nlm.nih.gov/21348514
https://pubmed.ncbi.nlm.nih.gov/21348514