Zobrazeno 1 - 10
of 18 451
pro vyhledávání: '"A. j, Mark"'
Autor:
Ektefaie, Yasha, Viessmann, Olivia, Narayanan, Siddharth, Dresser, Drew, Kim, J. Mark, Mkrtchyan, Armen
Protein inverse folding-that is, predicting an amino acid sequence that will fold into the desired 3D structure-is an important problem for structure-based protein design. Machine learning based methods for inverse folding typically use recovery of t
Externí odkaz:
http://arxiv.org/abs/2410.17173
Autor:
Bull, J. Mark, Coughtrie, Andrew, Deeptimahanti, Deva, Hedley, Mark, Laoide-Kemp, Caoimhín, Maynard, Christopher, Shepherd, Harry, van de Bund, Sebastiaan, Weiland, Michèle, Went, Benjamin
This study presents scaling results and a performance analysis across different supercomputers and compilers for the Met Office weather and climate model, LFRic. The model is shown to scale to large numbers of nodes which meets the design criteria, t
Externí odkaz:
http://arxiv.org/abs/2409.15859
Casualty insurance-linked securities (ILS) are appealing to investors because the underlying insurance claims, which are directly related to resulting security performance, are uncorrelated with most other asset classes. Conversely, casualty ILS are
Externí odkaz:
http://arxiv.org/abs/2407.14666
The classical 3SUM conjecture states that the class of 3SUM-hard problems does not admit a truly subquadratic $O(n^{2-\delta})$-time algorithm, where $\delta >0$, in classical computing. The geometric 3SUM-hard problems have widely been studied in co
Externí odkaz:
http://arxiv.org/abs/2404.04535
Autor:
Keil, J. Mark, Mondal, Debajyoti
A disk graph is an intersection graph of disks in $\mathbb{R}^2$. Determining the computational complexity of finding a maximum clique in a disk graph is a long-standing open problem. In 1990, Clark, Colbourn, and Johnson gave a polynomial-time algor
Externí odkaz:
http://arxiv.org/abs/2404.03751
Autor:
Moritz V. Warmbrunn, Ilias Attaye, Anthony Horak, Rakhee Banerjee, William J. Massey, Venkateshwari Varadharajan, Elena Rampanelli, Youling Hao, Sumita Dutta, Ina Nemet, Judith Aron-Wisnewsky, Karine Clément, Annefleur Koopen, Koen Wortelboer, Per-Olof Bergh, Mark Davids, Nadia Mohamed, E. Marleen Kemper, Stanley Hazen, Albert K. Groen, Daniel H. van Raalte, Hilde Herrema, Fredrik Backhed, J. Mark Brown, Max Nieuwdorp
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Imidazole Propionate (ImP), a gut-derived metabolite from histidine, affects insulin signaling in mice and is elevated in type 2 diabetes (T2D). However, the source of histidine and the role of the gut microbiota remain unclear. We conducted
Externí odkaz:
https://doaj.org/article/b22e925908314b35a5586a8bd491bf29
Autor:
Lisa Mazéas, Ahlem Bouguerba-Collin, J. Mark Cock, France Denoeud, Olivier Godfroy, Loraine Brillet-Guéguen, Tristan Barbeyron, Agnieszka P. Lipinska, Ludovic Delage, Erwan Corre, Elodie Drula, Bernard Henrissat, Mirjam Czjzek, Nicolas Terrapon, Cécile Hervé
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Brown algae belong to the Stramenopiles phylum and are phylogenetically distant from plants and other multicellular organisms. This independent evolutionary history has shaped brown algae with numerous metabolic characteristics sp
Externí odkaz:
https://doaj.org/article/64060c8268594719b10c3907310a05c5
Autor:
Isabel R. Barnet, Shannon R. Emerzian, Ramina Behzad, Daniel J. Brooks, Trinity Tedtsen, Marcela Granados, Sun Park, Joseph Moore, John D. Olson, Lamya Karim, Mary L. Bouxsein, J. Mark Cline, Jeffrey S. Willey
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Exposure to ionizing radiation for oncological therapy increases the risk for late-onset fractures in survivors. However, the effects of total body irradiation (TBI) on adult bone are not well-characterized. The primary aim of this study was
Externí odkaz:
https://doaj.org/article/df3ebdabc72b4be6b523528734f4c0e3
Autor:
Karthik Kanagaraj, Michelle A. Phillippi, Elizabeth H. Ober, Igor Shuryak, Norman J. Kleiman, John Olson, George Schaaf, J. Mark Cline, Helen C. Turner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract There are currently no available FDA-cleared biodosimetry tools for rapid and accurate assessment of absorbed radiation dose following a radiation/nuclear incident. Previously we developed a protein biomarker-based FAST-DOSE bioassay system
Externí odkaz:
https://doaj.org/article/54ce1567c9eb483a953a551bb96d2cf9
Autor:
Prasenjit Prasad Saha, Valentin Gogonea, Wendy Sweet, Maradumane L. Mohan, Khuraijam Dhanachandra Singh, James T. Anderson, Deepthi Mallela, Conner Witherow, Niladri Kar, Kate Stenson, Terri Harford, Michael A. Fischbach, J. Mark Brown, Sadashiva S. Karnik, Christine S. Moravec, Joseph A. DiDonato, Sathyamangla Venkata Naga Prasad, Stanley L. Hazen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Allosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, has previously been clinically assoc
Externí odkaz:
https://doaj.org/article/135a6fb0bc4149b78a90558a91ecc051