Výsledky vyhledávání

Akademický článek

The game-changing impact of POLE mutations in oncology—a review from a gynecologic oncology perspective

Autor: Johanna Kögl, Teresa L. Pan, Christian Marth, Alain G. Zeimet

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

Somatic mutations within the exonuclease proofreading domain (EDM) of the DNA polymerase Pol ϵ (POLE) gene are increasingly being discovered in ovarian, colorectal, urological, and, especially, endometrial carcinoma (EC), where these are found in up

Externí odkaz: https://doaj.org/article/51304ad18bba4291a5647a9faba1733a

Zobrazit plný text záznamu

Akademický článek

An uncommon case of POLE mutated uterine carcinosarcoma − complemented by a review of literature

Autor: C. Ebner, A. Frosch, K. Leitner, R. Soucek, C. Marth, AG. Zeimet

Publikováno v: Gynecologic Oncology Reports, Vol 54, Iss , Pp 101442- (2024)

Carcinosarcomas are high-grade endometrial cancers which enclose mesenchymal and epithelial differentiated components. The vast majority of these cancers belong to the p53 abnormal molecular subgroup and usually come with an unfavorable prognosis. PO

Externí odkaz: https://doaj.org/article/9273ba831ef6405385849fcc3bcdbc21

Zobrazit plný text záznamu

Akademický článek

PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)

Abstract Polybromo-1 (PBRM1) loss of function mutations are present in a fraction of biliary tract cancers (BTCs). PBRM1, a subunit of the PBAF chromatin-remodeling complex, is involved in DNA damage repair. Herein, we aimed to decipher the molecular

Externí odkaz: https://doaj.org/article/5241117531c4407f8106f8137c687dda

Zobrazit plný text záznamu