Zobrazeno 1 - 7
of 7
pro vyhledávání: '"A. Z. Spitz"'
Autor:
Adam Z. Spitz, Emmanouil Zacharioudakis, Denis E. Reyna, Thomas P. Garner, Evripidis Gavathiotis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The BCL-2 family protein BAX functions to regulate mitochondria-driven cell death. Here the authors show that the drug Eltrombopag inhibits BAX and prevents apoptosis induced by cytotoxic stimuli.
Externí odkaz:
https://doaj.org/article/31bab891d7f643189094349969145575
Autor:
Evripidis Gavathiotis, Adam Z. Spitz
Publikováno v:
Trends Pharmacol Sci
Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM). While the physiological function of BAX ensures tissue homeostasis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b274c7d96072998b6c2a576305657f
https://doi.org/10.1016/j.tips.2021.11.001
https://doi.org/10.1016/j.tips.2021.11.001
Autor:
Thomas P. Garner, Denis E. Reyna, Evripidis Gavathiotis, Emmanouil Zacharioudakis, Adam Z. Spitz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The BCL-2 family protein BAX has essential activity in mitochondrial regulation of cell death. While BAX activity ensures tissue homeostasis, when dysregulated it contributes to aberrant cell death in several diseases. During cellular stress BAX is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2216eca2fc911d4f0e885b5715f6b25
https://doaj.org/article/31bab891d7f643189094349969145575
https://doaj.org/article/31bab891d7f643189094349969145575
Publikováno v:
Current Opinion in Chemical Biology. 39:133-142
The network of protein-protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis. Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and excit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696ff074230bbbd18a3b1bd3fa2064b9
https://doi.org/10.1016/j.cbpa.2017.06.014
https://doi.org/10.1016/j.cbpa.2017.06.014
Autor:
Ross S. Firestone, Scott A. Cameron, Adam Z. Spitz, Peter C. Tyler, Vern L. Schramm, Rodrigo G. Ducati
Publikováno v:
Analytical chemistry. 88(23)
5′-Methylthioadenosine phosphorylase (MTAP) and 5′-methylthioadenosine nucleosidase (MTAN) catalyze the phosphorolysis and hydrolysis of 5′-methylthioadenosine (MTA), respectively. Both enzymes have low KM values for their substrates. Kinetic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9033458e0623f8e7cdeb744a67d74d4
https://pubmed.ncbi.nlm.nih.gov/27779859
https://pubmed.ncbi.nlm.nih.gov/27779859
Publikováno v:
ChemInform. 47
A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ecb246a4c412d3d8b3e6d88b21ae866
https://doi.org/10.1002/chin.201643062
https://doi.org/10.1002/chin.201643062
A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d155074da8fc3d072f8d53b74cad354c
https://europepmc.org/articles/PMC4814371/
https://europepmc.org/articles/PMC4814371/
