Výsledky vyhledávání - "A. Ya. Gerchikov"

Reactivity and mechanism of action of selenochromenes used as an inhibitor for the radical chain oxidation of 1,4-dioxane

Autor: S. I. Spivak, Veronika R. Hairullina, I. V. Safarova, Natalya V. Kurmakaeva, Anatoly Ya. Gerchikov, G. M. Sharipova

Publikováno v: Reaction Kinetics, Mechanisms and Catalysis. 131:89-100

Organometallic compounds based on selenochromene are known as potential drugs. Currently in the creation of new drugs in pharmacology their role as antioxidants is given great importance, since this characteristic is important for inhibiting the poss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cadf0852039256dcc0af1a41964675e9
https://doi.org/10.1007/s11144-020-01836-2

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Determination of the chain termination rate constants of the radical chain oxidation of organic compounds on antioxidant molecules by the QSPR method

Autor: Akhat G. Mustafin, A. Ya. Gerchikov, R. N. Nasretdinova, D. S. Mitsukova, Yu. Z. Martynova, V. R. Khairullina, G. G. Garifullina

Publikováno v: Russian Chemical Bulletin. 69:1679-1691

A quantitative analysis of the structure-antioxidant activity relationship was performed for 128 derivatives of phenols, amines, uracil, benzopyrane, and benzofuran using the GUSAR 2013 program. Nine statistically significant QSAR consensus models ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7f01fc708230aa1d84da4cea5ee8e4e
https://doi.org/10.1007/s11172-020-2948-7

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Quantitative structure–activity relationship of the thymidylate synthase inhibitors of Mus musculus in the series of quinazolin-4-one and quinazolin-4-imine derivatives

Autor: Felix S. Zarudii, A. R. Gimadieva, Akhat G. Mustafin, V. R. Khairullina, Anatoly Ya. Gerchikov

Publikováno v: Journal of Molecular Graphics and Modelling. 85:198-211

A quantitative structure–activity relationship analysis of the 2-methylquinazolin-4-one and quinazolin-4-imine derivatives, well-known antifolate thymidylate synthase (TYMS) inhibitors, has been performed in the range IC50 = 0.4÷380000.0 nmoL/L us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc026ceb21cd6f9fda29b38c68e1d9c
https://doi.org/10.1016/j.jmgm.2018.09.002

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QSAR Modelling of Thymidylate Synthase Inhibitors in a Series of Quinazoline Derivatives

Autor: F. S. Zarudii, V. R. Khairullina, A. Ya. Gerchikov, Alexey Lagunin

Publikováno v: Pharmaceutical Chemistry Journal. 51:884-888

Thymidylate synthase (ThS) is a target for antimetabolite antitumor drugs. Such drugs have been used in the clinic although they cause several severe side effects and accumulate in tissues. Therefore, new less toxic ThS inhibitors must be sought and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4db830d973b0e011b1e751aad2e2c51
https://doi.org/10.1007/s11094-018-1710-z

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Reactivity and mechanism of the action of C60 fullerene used as an inhibitor for the radical chain oxidation of 1,4-dioxane

Autor: I. V. Safarova, G. M. Sharipova, M. V. Sakhibgareeva, S. I. Spivak, A. Ya. Gerchikov

Publikováno v: Russian Journal of Physical Chemistry A. 91:1010-1014

The kinetics and mechanism of the antioxidative action of С60 fullerene are studied via highly sensitive manometry and kinetic spectrophotometry, based on the example of a model reaction of the initiated oxidation of 1,4-dioxane. The adequacy of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1ee6361794e8e36dae7eb5fc993ef12
https://doi.org/10.1134/s0036024417060103

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QSAR Assessing the Efficiency of Antioxidants in the Termination of Radical-Chain Oxidation Processes of Organic Compounds

Autor: Yuliya Z. Martynova, I. V. Safarova, V. R. Khairullina, Anatoly Ya. Gerchikov, G. M. Sharipova

Publikováno v: Molecules, Vol 26, Iss 421, p 421 (2021)
Molecules
Volume 26
Issue 2

Using the GUSAR 2013 program, the quantitative structure–antioxidant activity relationship has been studied for 74 phenols, aminophenols, aromatic amines and uracils having lgk7 = 0.01–6.65 (where k7 is the rate constant for the reaction of antio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8266bc48d9fe8e359d7428ba7b0337a5
https://doi.org/10.3390/molecules26020421

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Search for Nootropic Substances Based on Molecular Docking of Methanepyrido[1,2-a][1, 5]Diazocin[(-)-Cytisine] Derivatives to the Active Center of the Nicotinic Acetylcholine Receptor

Autor: F. S. Zarudii, A. Ya. Gerchikov, Inna P. Tsypysheva, V. R. Khairullina, M. N. Vasil’ev

Publikováno v: Pharmaceutical Chemistry Journal. 49:582-586

Docking of a series of methanepyrido[1,2-a][1,5]diazocin[(-)-cytisine derivatives to the active center of the nicotinic acetylcholine receptor was used to generate a set of potential substances for the treatment of cognitive dysfunction. The results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1bdbd266081ad38f39b3da8b6f928e8
https://doi.org/10.1007/s11094-015-1333-6

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